Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 5 Articles
Trolamine salicylate (TS) is a topical anti-inflammatory analgesic used to treat small joint\npain. The topical route is preferred over the oral one owing to gastrointestinal side effects. In this study,\na poly(lactide-co-glycolide) (PLGA)-based in situ bio-adhesive film-forming system for the transdermal\ndelivery of TS was designed and evaluated. Therefore, varying amounts (0%, 5%, 10%, 20%, and\n25% (w/w)) of PLGA (EXPANSORB® DLG 50-2A, 50-5A, 50-8A, and 75-5A), ethyl 2-cyanoacrylate,\npoly (ethylene glycol) 400, and 1% of TS were dissolved together in acetone to form the bio-adhesive\npolymeric solution. In vitro drug permeation studies were performed on a vertical Franz diffusion cell\nand dermatomed porcine ear skin to evaluate the distinct formulations. The bio-adhesive polymeric\nsolutions were prepared successfully and formed a thin film upon application in situ. A significantly\nhigher amount of TS was delivered from a formulation containing 20% PLGA����.....
Amphotericin B possesses high activity against Candida spp. with low risk of resistance.\nHowever, Amphotericin Bâ??s high molecular weight compared to other antifungal drugs, such as\nmiconazole and clotrimazole, and poor water solubility hampers its efficacy at the physiological\nconditions of the oropharyngeal cavity (saliva pH, limited volume for dissolution) and thereby limits\nits clinical use in oropharyngeal candidiasis. We have prepared fast-dissolving orodispersible films\nwith high loading (1% w/w) using solvent casting that enables amphotericin B to remain solubilised\nin saliva in equilibrium between the monomeric and dimeric states, and able to produce a local\nantifungal effect. Optimisation of the amphotericin B-loaded orodispersible films was achieved by\nquality by design studies combining dextran and/or maltodextrin as dextrose-derived-polymer film\nformers with cellulose-derived film formers (hydroxypropylmethyl/hydroxypropyl cellulose in a 1:4\nweight ratio), sorbitol for taste masking, microcrystalline cellulose (Avicel 200) or microcrystalline\ncellulose-carboxymethylcellulose sodium (Avicel CL-611) for enhancing the mechanical strength of the\nfilm, and polyethylene glycol 400 and glycerol (1:1 w/w) as plasticizers. The optimised amphotericin B\norodispersible films (containing 1% AmB, 25% dextran, 25% maltodextrin, 5% sorbitol, 10% Avicel\n200, 10% polyethylene glycol 400, 10% glycerol, 3% hydroxypropylmethyl cellulose acetate succinate,\n12% hydroxypropyl cellulose) possessed a fast disintegration timeâ?¦â?¦â?¦â?¦â?¦.....
In this paper, it is proposed that polymer-coated magnetic nanorods (MNRs) can be\nused with the advantage of a double objective: first, to serve as magnetic hyperthermia agents,\nand second, to be used as magnetic vehicles for the antitumor drug doxorubicin (DOX). Two different\nsynthetic methodologies (hydrothermal and co-precipitation) were used to obtain MNRs of maghemite\nand magnetite. They were coated with poly(ethyleneimine) and poly(sodium 4-styrenesulfonate),\nand loaded with DOX, using the Layer-by-Layer technique. Evidence of the polymer coating and\nthe drug loading was justified by ATR-FTIR and electrophoretic mobility measurements, and the\ncomposition of the coated nanorods was obtained by a thermogravimetric analysis. The nanorods\nwere tested as magnetic hyperthermia agents, and it was found that they provided sufficiently large\nheating rates to be used as adjuvant therapy against solid tumors. DOX loading and release were\ndetermined by UV-visible spectroscopy, and it was found that up to 50% of the loaded drug was\nreleased in about 5 h, although the rate of release could be regulated by simultaneous application of\nhyperthermia, which acts as a sort of external release-trigger. Shape control offers another physical\nproperty of the particles as candidates to interact with tumor cells, and particles that are not too\nelongated can easily find their way through the cell membrane....
In the current study, the development of mucoadhesive tablets for buccal\ndelivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes\nwith piroxicam and cyclodextrins (beta-cyclodextrin (beta-CD), methylated-beta-cyclodextrin (Me-beta-CD),\nand hydroxypropyl-beta-cyclodextrin (HP-beta-CD)) were prepared by the co-evaporation method. All\nformulations were characterized by means of differential scanning calorimetry, infrared spectroscopy\nand powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by\ndirect compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets\nwere conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa.\nThe results suggest that the rank order effect of cyclodextrins for the drug release was Me-beta-CD >\nHP-beta-CD > beta-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly\nincreased the transport of the drug compared to their free complexes. Finally, histological assessment\nrevealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins....
This investigation aims to study the characteristics and release properties of lutein-loaded\npolyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order\nto increase PVA/SA nanofibersâ?? water-resistant ability for potential biomedical applications,\nthe electrospun PVA/SA nanofibers were cross-linked with a mixture of glutaraldehyde and\nsaturated boric acid solution at room temperature. The nanofibers were characterized using scanning\nelectron microscopy (SEM) and X-ray diffractometer (XRD). Disintegration time and contact angle\nmeasurements testified the hydrophilicity change of the nanofibers before and after cross-linking.\nThe lutein release from the nanofibers after cross-linking was measured by an ultraviolet absorption\nspectrophotometer, which showed sustained release up to 48 h and followed anomalous (non-Fickian)\nrelease mechanism as indicated by diffusion exponent value obtained from the Korsmeyer-Peppas\nequation. The results indicated that the prepared lutein-loaded PVA/SA nanofibers have great\npotential as a controlled release system....
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