Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 6 Articles
The menopausal transition, or perimenopause, is characterized by menstrual irregularities,\nvasomotor symptoms, sleep disturbances, mood symptoms, and urogenital tract atrophy. These\nchanges can also affect the quality of life and oneâ??s self-esteem. Hormone replacement therapy\n(HRT) is considered the best option to achieve therapeutic relief of different menopausal symptoms\nbut is usually restricted to moderate or severe symptoms. Moreover, many women refuse HRT for\na variety of reasons concerning the fear of cancer and other adverse effects. According to these\nconsiderations, new topics are emerging: Dissatisfaction with drug costs and conventional\nhealthcare, desire for personalized medicines, and the public perception that â??natural is goodâ?. In\nthis context, nonhormonal therapies are mostly evolving, and it is not unusual that women often\nrequest a â??naturalâ? approach for their symptoms. The aim of this study is to investigate\nnonhormonal therapies that have been identified to reduce the menopausal symptoms....
Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic\nliver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments,\nwe evaluated an anti-inflammatory and antioxidant nutraceutical rich in docosahexaenoic acid (DHA)\nas a possible therapy for ACLD. We investigated the effects of two-week DHA supplementation\n(500 mg/kg) on hepatic fatty acids, PH, oxidative stress, inflammation, and hepatic stellate cell\n(HSC) phenotype in rats with ACLD. Additionally, the effects of DHA were evaluated in murine\nmacrophages and human HSC. In contrast to vehicle-treated animals, cirrhotic rats receiving DHA\nreestablished a healthy hepatic fatty acid profile, which was associated with an improvement in PH.\nThe mechanisms underlying this hemodynamic improvement included a reduction in oxidative stress\nand inflammation, as well as a marked HSC deactivation, confirmed in human HSC. Experiments\nwith cultured macrophages showed that treatment with DHA protects against pro-inflammatory\ninsults. The present preclinical study demonstrates that a nutraceutical rich in DHA significantly\nimproves PH in chronic liver disease mainly by suppressing inflammation and oxidative stress-driven\nHSC activation, encouraging its evaluation as a new treatment for PH and cirrhosis....
Widely prevalent deficiency of dietary fiber intake in daily food has led to widespread prevalence of absence of normal bowel movement and constipation. In response, instead of making up dietary fiber deficiency, paradoxically, non-food laxatives such as Psyllium husk, lactulose, maltitol, Ayurvedic medicines, other adjunctive medicines and similar laxatives are in wide use to overcome these problems. In general, high dietary foods have low palatability. LeFiber is a palatable high dietary fiber supplement to fulfill the deficiency of dietary fiber; which includes fiber of green leafy vegetable as one of the ingredients. The open label, double arm, prospective study to determine efficacy of 3•3 grams dietary fiber/dose given three times a day with food had normalizing bowel movements as primary end point and enriching gut flora in colon as indicated by Bifidobacteria as secondary outcome. In the clinical trial, this was compared to Psyllium husk as control in standard dose. This trial is registered with ClinicalTrials.gov No. CTRI no. CTRI/2018/04/13078. Results show that LeFiber is as effective as Psyllium husk in normalizing bowel movements. Longo score as Rome III Diagnostic Criteria for Functional Gastrointestinal Disorder- C3 was calculated. Mean Longo Score on day 0 for LeFiber was 9•03 from which the mean Longo Score decreased statistically significantly at P <0•0001 to 5•61 on day 7th, 1•42 at day 15th and 2•61 at day 30th. LeFiber enriched gut flora as indicated by increase in the number of Bifidobacteria which either declined or totally wiped out in the Psyllium husk arm....
This paper presents the results of a research in urban ethnobotany, conducted in a market of Bolivian immigrants in the neighborhood\nof Liniers, Ciudad Autoâ??noma de Buenos Aires (Argentina). Functional foods and nutraceuticals belonging to 50 species of\n18 families, its products, and uses were recorded. Some products are exclusive from the Bolivian community; others are frequent\nwithin the community, but they are also available in the general commercial circuit; they are introduced into it, generally, through\nshops called diet´eticas (â??health-food storesâ?), where products associated with the maintenance of health are sold. On this basis, the\ntraditional and nontraditional components of the urban botanical knowledge were evaluated as well as its dynamics in relation to\nthe diffusion of the products. Both the framework and methodological design are innovative for the studies of the urban botanical\nknowledge and the traditional markets in metropolitan areas....
Aging is a complex and inevitable biological process that is associated with numerous chronically debilitating health effects.\nDevelopment of effective interventions for promoting healthy aging is an active but challenging area of research. Mechanistic\nstudies in various model organisms, noticeably two invertebrates, Caenorhabditis elegans and Drosophila melanogaster, have\nidentified many genes and pathways as well as dietary interventions that modulate lifespan and healthspan. These studies have\nshed light on some of the mechanisms involved in aging processes and provide valuable guidance for developing efficacious aging\ninterventions. Nutraceuticals made from various plants contain a significant amount of phytochemicals with diverse biological\nactivities. Phytochemicals can modulate many signaling pathways that exert numerous health benefits, such as reducing cancer\nincidence and inflammation, and promoting healthy aging. In this paper, we outline the current progress in aging intervention\nstudies using nutraceuticals from an evolutionary perspective in invertebrate models....
Fish is the source of polyunsaturated fatty acids, especially omega-3 fatty acids. Linolenic acid, Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) are omega-3 fatty acids. Omega 3 fatty acids have very much importance in the food industry. In the present work, fish oil was extracted using the supercritical CO2 method and compared with soxhlet extraction method in quality and yield. Supercritical fluid extraction conditions were optimized in terms of time, temperature and pressure with an objective of getting the quality of extracted oil and in a cost effective manner. The fatty acid composition of oils was determined by GC/MS analysis. From this study, it was concluded that Supercritical CO2 process is better than soxhlet method in terms of desired fatty acid extraction i.e. omega-6 and omega-3 fatty acids....
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