Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 5 Articles
Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral\nbioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for\nits high intra- and inter-subject absorption variability in humans. To overcome these limitations a\nnovel self-emulsifying drug delivery system (SEDDS) based on VESIsorb® formulation technology\nincorporating CBD, as Hemp-Extract, was developed (SEDDS-CBD). The study objective was to\nevaluate the pharmacokinetic profile of SEDDS-CBD in a randomized, double-blind, cross-over design\nin 16 healthy volunteers under fasted conditions. As reference formulation, the same Hemp-Extract\ndiluted with medium-chain triglycerides (MCT-CBD) was used. CBD dose was standardized to\n25 mg. Pharmacokinetic parameters were analyzed from individual concentration-time curves���.....
Furosemide, a chloride channel blocker ordinarily used as a high-ceiling or loop diuretic,\nis practically insoluble in water and dilute acids. Due to its acidic nature, furosemide is mostly\nabsorbed in the stomach and in the upper small intestine. Efforts have focused on the development\nof sustained release systems of furosemide in order to improve the effectiveness of the drug, which\nexhibits poor aqueous solubility and poor permeability. Recently, electrospun nanofibrous drug\ndelivery systems have emerged as promising alternative solid-dosage forms due to their advantages\nof high porosity, high surface to volume ratio, and high drug-loading efficacy. Herein, a number of\nnanofibrous mats composed of different types of Eudragit® polymers in various concentrations and\ncombinations loaded with furosemide were designed, successfully electrospun, and characterized\nusing SEM, FTIR, DSC, and TGA analyses. The nanofibrous nonwovens were formulated in nanofiber\ntablets and the release profile of furosemide from them was evaluated at pH 1.2 and 6.8 and compared\nto that of physical mixture matrix tablets of analogous composition as well as to that of a commercial\nformulation. It was found that the release of furosemide was compatible with the gastroretentive and\nslower intestinal release requirements with a well-defined absorption window, while some nanofiber\nformulations could act as furosemide carriers in emergency situations where a relatively fast onset of\nits action is required, as in the case of critically ill post-traumatic patients....
We investigated and monitored in situ the wetting and dissolution properties of polymeric\nnanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used\nas a low-dose and poorly-soluble model drug, and hydroxypropyl methylcellulose (HPMC) and\npolydextrose (PD) were used as carrier polymers for electrospinning (ES). The initial-stage dissolution\nof the nanofibers was monitored in situ with three-dimensional white light microscopic interferometry\n(SWLI) and high-resolution optical microscopy. The physical solid-state characterization of nanofibers\nwas performed with Raman spectroscopy, X-ray powder diffraction (XRPD), and scanning electron\nmicroscopy (SEM). We showed that PRX recrystallizes in a microcrystalline form immediately after\nwetting of nanofibers, which could lead to enhanced dissolution of drug. Initiation of crystal\nformation was detected by SWLI, indicating: (1) that PRX was partially released from the nanofibers,\nand (2) that the solid-state form of PRX changed from amorphous to crystalline. The amount,\nshape, and size of the PRX crystals depended on the carrier polymer used in the nanofibers and\ndissolution media (pH). In conclusion, the present nanofibers loaded with PRX exhibit a quasi-dynamic\ndissolution via recrystallization. SWLI enables a rapid, non-contacting, and non-destructive method\nfor in situ monitoring the early-stage dissolution of nanofibers and regional mapping of crystalline\nchanges (re-crystallization) during wetting. Such analysis is crucial because the wetting and\ndissolution of nanofibers can greatly influence the performance of nanofibrous drug delivery systems\nin pharmaceutical and biomedical applications.\n\n\n....
White horehound (Marrubium vulgare L.), is a grey-leaved perennial herb, belonging to\nLamiaceae family, distributed in Eurasia and northern Africa. Despite the fact that M. vulgare has\nbeen used since ancient times in treating diverse diseases, it is only in the last decade or so that\nscientists have been able to lay the foundation for its potential pharmacological actions from the\nresults observed through the prism of ethnopharmacological use of this species. The novelty of this\nstudy was that subcritical water extraction, acknowledged as a powerful extraction technology to\nrecover phenolic compounds, was coupled with spray drying. The subcritical horehound extract,\nobtained using optimal process parameters, was used as a liquid feed in spray drying. Maltodextrin\nwas used as a carrier in a concentration of 10%. Thus, two M. vulgare powders, carrier-free and 10%\nMD, were produced. Comprehensive powders characterization was conducted in order to evaluate\ntheir quality. Results confirmed that spray drying can be used as a method of choice for obtaining\nhigh quality horehound powders which kept the amorphous structure constant after 6 months....
Today, efficient delivery of sorafenib to hepatocellular carcinoma remains a challenge for\ncurrent drug formulation strategies. Incorporating the lipophilic molecule into biocompatible and\nbiodegradable theranostic nanocarriers has great potential for improving the efficacy and safety of\ncancer therapy. In the present study, three different technologies for the encapsulation of sorafenib into poly���...
Loading....