Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 5 Articles
Background: Ainhum is an idiopathic dermatological disease characterized by a progressive constricting ring\nusually on the fifth toe, which may lead to spontaneous auto-amputation of the affected toe. Timely diagnosis and\ntreatment are the key elements to avert amputations with resultant mutilating deformities, permanent handicaps\nand psychological sequelae. Though common in African descents, this pathology has not been described in the\nCameroonian literature. Herein, we report the case of an adult Cameroonian woman presenting with ainhum.\nCase presentation: A 54-year old Cameroonian was admitted to our primary healthcare centre with a 6-month\nhistory of a painful constriction band developing at the base of her right fifth toe. Her past history was uneventful.\nBased on the absence of trauma and spontaneous onset of the condition, the diagnosis of ainhum was most\nsuggestive. She was managed surgically by excision of the band, disarticulated at right fifth metatarsophalangeal\njoint and skin closure. Her post-operative course after 1 year was uneventful.\nConclusion: Here we presented a case of ainhum, a rare dermatological disease with few reports. In view of the\nserious complications of ainhum such as mutilating deformities with permanent physical disabilities and\npsychological trauma, we draw cliniciansâ?? attention, especially wound care specialists to this rare but potentially\nhandicapping disease, for timely diagnosis and management....
Dermatomycoses are a group of diseases worldwide distributed and affect\nskin, hair and nails. Several fungal species can be envolved and keratinophilic\nfungi belonging to the genera Trichophyton, Microsporum and Epidermophyton\nare very common. These infections are globally distributed and their\nincidence has progressively increased. Despite their high incidence, few studies\nhave been carried out in HIV-infected patients, regarding frequency, clinical\npresentations, and species identification. This study aimed to evaluate some\nepidemiological and clinical aspects of dermatophytosis in HIV-infected patients\nand to attempt phenotypical and molecular characteristics of their\nagents. Of 398 patients included, 306 were HIV-infected. Clinical data and\nsamples of skin, hair and nail lesions were simultaneously obtained. The\ndermatophytes yielded in culture were phenotypically identified and evaluated\nby ITS-RFLP and ITS (Internal Transcribed Space) sequencing. Dermatophytes\nfrequency in HIV-infected patients with cutaneous lesions was\n11.76% similar to the 15.22% observed in non-HIV individuals. Trichophyton\nrubrum was the most common isolated species in both groups. Throught\nITS-RFLP, 29/32 (90.63%) of dermatophytes isolates were identified at the\nspecies level. From the 10 isolates randomly selected for ITS sequencing, seven\nconfirmed the ITS-RFLP results while three Trichophyton sp. were not\nidentified as dermatophytes. The identification of these species in HIV-infected\npatients is highly desirable in order to improve the knowledge of their frequency, geographical distribution and relation to clinical presentation....
Introduction: The Cussons Baby Sensicare Range is a newly developed set of\nproducts specially formulated for newborn, sensitive and eczema prone skin.\nAs such, these products need to be tested to evaluate their skin irritation and\nsensitization potential before use. The products were evaluated with two separate\ntests. The first test was conducted in a single-center, within-subject\ncomparison using assessor-blind, randomised human skin irritation patch\ntest (48 hour/96 hour exposure) and conducted on healthy adults with sensitive,\natopic skin. The second test was conducted in a single-center, controlled\n(sterile water), within subject using human repeat-insult patch tests (HRIPTs)\nand conducted on healthy female Indonesian and Asian adult female subjects,\nwith sensitive skin. The sensitization potential of each product was determined\nfrom International Contact Dermatitis Research Group (ICDRG)\nscores at 30 minutes, 24 hours, 48 hours and 72 hours after patch removal.\nSkin irritation tests show that all products were significantly lower than the\npositive control sodium lauryl sulphate (SLS) (p < 0.05) but not significantly\ndifferent to the negative control (sterile water) in terms of irritation scores at\nthe respective time points. HRIPTs results show that Cussons Baby Sensicare\nRange was non-sensitizing. As such, it can be concluded that the Cussons\nBaby Sensicare Range tested is well tolerated on skin and has low skin irritation\nand sensitization potential. Thus, they can be considered hypoallergenic \non sensitive skin and suitable for eczema prone skin....
Psoriatic arthritis (PsA) is a complex immune-mediated disease and its pathogenesis\ndepends both on genetic factors and environment. PsA patients\nmay present a wide range of clinical manifestations including skin and nail\nabnormalities. Indeed, articular involvement is variable too. Disease development\nrelies on a heterogeneous net made of multiple cytokines pathways\nwhich are regulated by several factors including human leucocyte antigen\n(HLA) expression, miRNAs, microbiome. Among genetic polymorphisms\nwhich can lead to abnormal cytokine expression, tumor necrosis factor (TNF)\npolymorphisms have been studied. Thus, leading to the development of new\ntherapeutic agents. Finally, further studies on genetic factors and epigenetics\nwill give new insights into this complex disorder. The aim of this mini-review\nis to provide the reader with a summary of the fundamental and most innovative\naspects of genetic and epigenetic factors involved in the PsA, thus including\nhuman leucocyte antigen (HLA) expression, tumor necrosis factor\n(TNF) polymorphisms, micro RNAs and microbiome....
Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine\nand is characterized by atrophy of intestinal villi. The manifestations of the disease improve following\na gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin\nmanifestations are described in CD patients. The present paper reviews all CD-associated skin\ndiseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved\nin these associations. Different hypotheses have been proposed to explain the possible mechanisms\ninvolved in every association between CD and cutaneous manifestations. An abnormal small\nintestinal permeability seems to be implicated in various dermatological manifestations. However,\nmost of the associations between CD and cutaneous diseases is based on case reports and case series\nand a few controlled studies. To better assess the real involvement of the cutaneous district in CD\npatients, large multicentric controlled clinical trials are required....
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