Current Issue : July - September Volume : 2020 Issue Number : 3 Articles : 5 Articles
Currently available gels like hydrogel and other have their physical stability issues as the polymers tend to coagulate or degrade during storage in high temperature countries. It is also not practical advisable to store such external preparations in refrigerator. Gels prepared with fumed silica are thermally independent as such these gels do not change their rheological properties even at high temperature. Gel formulations of fluconazole for topical application were prepared by using different percentages of Aerosil 200 Pharma (colloidal silicon dioxide) as a gelling agent. The poor water solubility of fluconazole was overcome by cosolvency approach using 10:10:15 ratio of water, propylene glycol and polyethylene glycol, respectively. FTIR studies revealed that there was no interaction between fluconazole and gelling agent. The formulated fluconazole gels were evaluated for physical appearance, drug content, pH, spreadability, extrudability, viscosity, in-vitro antifungal studies and found satisfactory. In-vitro release studies were carried out by Franz diffusion cell using phosphate buffer, pH 7.4 at 50 rpm. The cumulative drug released from formulation F-6 (9% of Aerosil 200 pharma) was found to be 99.98% after 90 minutes. Stability studies were conducted for the optimized formulation F6 as per ICH guidelines for a period of 90 days by storing at different temperatures (4 ± 2 °C, room temperature and 40±2 °C) and results showed that formulation was stable. A simple, accurate and precise stability indicating HPLC and TLC analytical method was developed for the analysis of Fluconazole gel formulations. Fluconozole gels prepared with Aerosil 200 pharma performed better than marketed gel, leading to improved thermal stability and efficacy....
In this study, we aimed to develop a 20(S)-protopanaxadiol (PPD)-loaded self-nanoemulsifying\ndrug delivery system (SNEDDS) preconcentrate (PSP) using comprehensive ternary phase diagrams for\nenhanced solubility, physical stability, dissolution, and bioavailability. Capmul MCM C8 and Capryol\n90 were selected as the oil phase owing to the high solubility of PPD in these vehicles (>15%, w/w).\nNovel comprehensive ternary phase diagrams composed of selected oil, surfactant, and PPD were\nconstructed, and the solubility of PPD and particle size of vehicle was indicated on them for\nthe effective determination of PSP. PSPs were confirmed via particle size distribution, physical\nstability, and scanning electron microscope (SEM) with the dispersion of water. The optimized PSP\n(CAPRYOL90/Kolliphor EL/PPD = 54/36/10, weight%) obtained from the six possible comprehensive\nternary phase diagrams showed a uniform nanoemulsion with the particle size of 125.07.....................
Microneedles are emerging drug delivery methods for painless treatment. The current\nstudy tested dissolving microneedles containing lidocaine (Li-DMN) for use in local anesthesia.\nAn Li-DMN patch was fabricated by centrifugal lithography with carboxymethyl cellulose as a\nstructural polymer and assessed for physical properties by optical microscopy and a fracture force\nanalyzer. The biocompatibility was evaluated by a histology section in vitro and by ear thickness\nin vivo. The efficacy of the Li-DMN patch was assessed by electrophysiological recordings in primary\ncultured sensory neurons in vitro and a von Frey test on ratsâ?? hind paws in vivo. The physical\nproperties of the microneedle showed enough rigidity for transdermal penetration. The maximal\ncapacity of lidocaine-HCl in the Li-DMN patch was 331.20......................
The aim of the present study was to formulate fast dissolving tablet of oseltamivir using superdisintegrants with the help of solid dispersion technique to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Solid dispersion of oseltamivir was prepared with PVP K30 in different drug: carrier ratio using solvent evaporation methods. The optimized solid dispersion (drug: PVP K30, 1:0.5 ratio) were further used to prepare fast dissolving tablet by direct compression method using superdisintegrants such as crospovidone and xanthan gum. Infrared spectroscopy, differential scanning calorimetry and x-ray diffraction were performed to identify the physicochemical interaction between drug and optimized formulation. The pre-compression parameter of prepared powder blends all formulation suggested good flowability and compressibility. The prepared tablets were evaluated for thickness, hardness, friability and weight variation, drug content, wetting time, disintegration time and in-vitro dissolution studies. The batch F12- shows highest release of 99.87 % in 25 min....
In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles\nwere prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin.\nCharacterization measurements showed that the insulin-loaded microparticles display irregular\nporosity and shape. The encapsulation efficiency and loading capacity of insulin were >82%\nand 18%, respectively. The release of insulin varied between 68% and 92% depending on the\nmicroparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in\na significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration\nshowed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric\nmicroparticle-based formulations. These results indicate the possible oral delivery of insulin using\nthis combination of polymers....
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