Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 5 Articles
The clinical efficacy of methotrexate (MTX) is limited by its poor water solubility, its\nlow bioavailability, and the development of resistance in cancer cells. Herein, we developed novel\nfolate redox-responsive chitosan (FTC) nanoparticles for intracellular MTX delivery. l-Cysteine and\nfolic acid molecules were selected to be covalently linked to chitosan in order to confer it redox\nresponsiveness and active targeting of folate receptors (FRs). NPs based on these novel polymers\ncould possess tumor specificity and a controlled drug release due to the overexpression of FRs and\nhigh concentration of reductive agents in the microenvironment of cancer cells. Nanoparticles (NPs)\nwere prepared using an ionotropic gelation technique and characterized in terms of size, morphology,\nand loading capacity. In vitro drug release profiles exhibited a glutathione (GSH) dependence.\nIn the normal physiological environment, NPs maintained good stability, whereas, in a reducing\nenvironment similar to tumor cells, the encapsulated MTX was promptly released. The anticancer\nactivity of MTX-loaded FTC-NPs was also studied by incubating HeLa cells with formulations for\nvarious time and concentration intervals. A significant reduction in viability was observed in a\ndose- and time-dependent manner. In particular, FTC-NPs showed a better inhibition effect on HeLa\ncancer cell proliferation compared to non-target chitosan-based NPs used as control. The selective\ncellular uptake of FTC-NPs via FRs was evaluated and confirmed by fluorescence microscopy. Overall,\nthe designed NPs provide an attractive strategy and potential platform for efficient intracellular\nanticancer drug delivery....
Bone tuberculosis (TB) caused by mycobacterium tuberculosis continues to present a formidable challenge to humans. To effectively\ncure serious bone TB, a novel kind of composite scaffolds with long-term dual drug release behaviours were prepared to satisfy the\nneeds of both bone regeneration and antituberculosis drug therapy.............................
In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a\npaclitaxel/curcumin codelivery system���������.....
Therapies against stroke can restore the blood supply but cannot prevent the ischemic\ndamage nor stimulate the recovery of the infarcted zone. The neuroglobin protein plays an important\nrole in the neuro-regeneration process after stroke; however, the method for its effective systemic\napplication has not been identified yet, as neuroglobin is unable to pass through the blood-brain barrier.\nPreviously, we developed different types of sodium hyaluronate nanoparticles, which successfully\ncross the blood-brain barrier after stroke...........................
Nanostructured materials play a fundamental role in orthopedic research owing to their outstanding properties and excellent\nbiocompatibility. Titania nanotube (TNT) arrays engineered by electrochemical anodization process have been extensively\nexplored and used as effective carriers for controlled drug delivery. In this study, we proposed a drug delivery system based on\ncoordination bond�����.....
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