Current Issue : July - September Volume : 2020 Issue Number : 3 Articles : 5 Articles
The aims of this study were to investigate the antioxidant, hypolipidemic and hepatic\nprotective effects of Phascolosoma esculenta polysaccharides (PEP). PEP was prepared from Phascolosoma\nesculenta by enzyme hydrolysis and its characterization was analyzed. The antioxidant activities of\nPEP were evaluated by the assays of scavenging 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide\nanion, hydroxyl radicals and chelating ferrous ion in vitro. It showed that PEP could scavenge\nradicals effectively and had favorable antioxidant activities. In the meantime, the hypolipidemic\neffect of PEP was investigated in vivo by using mice model fed with high-fat diet with or without\nPEP treatment. Compared with the hyperlipidemic mice without treatment, the serum levels of total\ncholesterol (TC)................
Piper sylvaticum Roxb. is traditionally used by the indigenous people of tropical and\nsubtropical countries like Bangladesh, India, and China for relieving the common cold or a variety\nof chronic diseases, such as asthma, chronic coughing, piles, rheumatic pain, headaches, wounds,\ntuberculosis, indigestion, and dyspepsia. This study tested anxiolytic and antioxidant activities by\nin vivo, in vitro, and in silico experiments for the metabolites extracted (methanol) from the leaves and\nstems of P. sylvaticum (MEPSL and MEPSS). During the anxiolytic evaluation analyzed by elevated\nplus maze and hole board tests, MEPSL and MEPSS (200 and 400 mg/kg, body weight) exhibited a\nsignificant and dose-dependent reduction of anxiety-like behavior in mice. Similarly, mice treated\nwith MEPSL and MEPSS demonstrated dose-dependent increases in locomotion and CNS simulative\neffects in open field test. In addition, both extracts (MEPSL and MEPSS) also showed moderate\nantioxidant activities in DPPH scavenging and ferric reducing power assays compared to the standard,\nascorbic acid. In parallel, previously isolated bioactive compounds from this plant were documented\nand subjected to a molecular docking study to correlate them with the pharmacological outcomes.\nThe selected four major phytocompounds displayed favorable binding affinities to potassium channel\nand xanthine oxidoreductase enzyme targets in molecular docking experiments. Overall, P. sylvaticum\nis bioactive, as is evident through experimental and computational analysis. Further experiments are\nnecessary to evaluate purified novel compounds for the clinical evaluation....
Dissotis rotundifolia is a plant in the family Melastomataceae. The methanolic extract of the whole plant is reported to be rich in\nC-glycosylflavones such as vitexin and orientin. Though there are several reports on the ethnomedicinal use of this plant extract in\nstomach ulcers, experimental-based data is unavailable. The drive for carrying out this research was to obtain data on the possible\nameliorative effect of the whole plant extract of Dissotis rotundifolia (DRE) in gastric ulcerations induced by ethanol in Sprague\nDawley (SD) rats. SD rats were pretreated with 100, 300, and 500 mg/kg of DRE for 14 days after which an ulcerogen-ethanol was\nadministered. Gross examinations of the stomach lining and histological analysis of gastric lesions were carried out coupled with\nan assessment of the antioxidant activity of gastric mucosa using MDA, GSH, CAT, and SOD as indicators. The data suggested a\nsignificant attenuation in gastric mucosal damage in DRE-pretreated ethanol-induced gastric ulcer reflected in the antioxidant\nstatus. There was also a reduction or absence of hemorrhage, edema, and leucocytes infiltration in DRE-treated groups compared\nto the negative control group. DRE conserved glutathione (GSH) levels, reduced malondialdehyde (MDA) levels, and enhanced\ncatalase (CAT) and superoxide dismutase (SOD) enzyme levels. The present study shows that DRE possess protective effects\nagainst ethanol-induced ulcer damage in the stomach of rats, which could be attributed to its antioxidant activity....
In this study, anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies were evaluated. The oxidative burst assay\nusing the chemiluminescence technique, MTT assay, brine shrimp lethality assay, and FTIR analysis were the methods used for\nthe evaluation of anti-inflammatory, anticancer, brine shrimp lethality, and FTIR studies, respectively. The whole-plant butanol\nfraction of Heliotropium europaeum (WBFHE) showed anti-inflammatory activity on ROS having IC50 14:7................
Ultraviolet B (UVB) radiation is the main cause of photoaging processes including cellular senescence, skin drying, collagen\ndegradation, melanogenesis, and inflammation. these responses occur because UVB induces a change in expression of agingrelated\ngenes through regulation of signal pathways such as that of mitogen-activated protein kinases- (MAPKs-) activator protein\n1 (AP-1). Ranunculus bulumei, which is used as an herb in Indonesia, belongs to the Ranunculaceae family, which has been\nreported to perform various physiological effects including antioxidant and anti-inflammation. However, data on the pharmaceutical\nand cosmeceutical utility of Ranunculus bulumei have not been reported. Therefore, we evaluated the antiaging efficacy\nof RB-ME, a methanol extract of Ranunculus bulumei. Rb-ME attenuated MMP9 and COX-2 gene expression but enhanced SIRT1\nand type-1 collagen in UVB-irradiated HaCaT cells. Rb-ME regulated these gene expressions through inhibition of p38\nphosphorylation and inactivation of AP-1. In addition, mRNA expression of HAS-2 and -3, which are involved in skin hydration,\nwas elevated in Rb-ME-treated HaCaTcells. Rb-ME also inhibited melanogenesis by suppression of tyrosinase, MITF, and TYRP-\n1 mRNA in B16F10 cells under Alpha-MSH treatment. Taken together, these results indicate that Rb-ME has a protective effect on\nsome UVB-induced skin photoaging events such as inflammation, collagen degradation, cellular senescence, skin drying, and\nmelanin production through inhibition of the p38-AP-1 signal cascade, indicating that Rb-ME can be used as an active ingredient\nfor antiaging cosmetics....
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