Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 5 Articles
Chronic fatigue syndrome (CFS) is one of the most intractable diseases and is\ncharacterized by severe central fatigue that impairs even daily activity. To date, the\npathophysiological mechanisms are uncertain and no therapies exist. Therefore, a proper animal\nmodel reflecting the clinical features of CFS is urgently required. We compared two CFS animal\nmodels most commonly used, by injection with lipopolysaccharide (LPS from Escherichia coli\nO111:B4) or polyinosinic: polycytidylic acid (poly I:C), along with bilateral adrenalectomy (ADX) as\nanother possible model. Both LPS- and poly I:C-injected mice dominantly showed depressive\nbehaviors, while ADX led to fatigue-like performances with high pain sensitivity. .............................
Hyperlipidemia is a chronic disorder that plays an important role in the development of\ncardiovascular diseases, type II diabetes, atherosclerosis, hypertension, and non-alcoholic fatty liver\ndisease. Hyperlipidemias have created a worldwide health crisis and impose a substantial burden\nnot only on personal health but also on societies and economies. Transcription factors in the sterol\nregulatory element binding protein (SREBP) family are key regulators of the lipogenic genes in the\nliver. SREBPs regulate lipid homeostasis by controlling the expression of a range of enzymes required\nfor the synthesis of endogenous cholesterol, fatty acids, triacylglycerol, and phospholipids. Thereby,\nSREBPs have been considered as targets for the treatment of metabolic diseases. The aim of this study\nwas to investigate the beneficial functions and the possible underlying molecular mechanisms of\nSREBP decoy ODN, which is a novel inhibitor of SREBPs, in high-fat diet (HFD)-fed hyperlipidemic\nmice. ...............................
Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM)\nis an inherited neurodegenerative disorder of unknown etiology. Clinical signs of neurological\ndeficits develop within the first year of life in vitamin E (vitE) deficient horses. A genome-wide\nassociation study (GWAS) was carried out using 670,000 SNP markers in 27 case and 42 control\nQuarter Horses. Two markers, encompassing a 2.5 Mb region on ECA7, were associated with the\nphenotype (p = 2.05 * 10-7 and 4.72 * 10-6). ...................
Krabbe disease (KD) is an autosomal recessive sphingolipidosis caused by the deficiency\nof the lysosomal hydrolase Beta-galactosylceramidase (GALC). Oligodendroglia degeneration and\ndemyelination of the nervous system lead to neurological dysfunctions which are usually lethal by\ntwo years of age. At present, the only clinical treatment with any proven efficacy is hematopoietic\nstem-cell transplantation, which is more effective when administered in the neonatal period to\npresymptomatic recipients. Bone marrow (BM) sinusoidal endothelial cells (SECs) play a pivotal\nrole in stem cell engraftment and reconstitution of hematopoiesis. Previous observations had shown\nsignificant alterations of microvascular endothelial cells in the brain of KD patients and in................
Background and objectives: Oxidative stress and inflammation have been implicated\nin the etiology of irritable bowel syndrome (IBS), a common gastrointestinal functional disease.\nThis study aimed to further characterize the contention-stress rat model by exploring a possible\ncorrelation between oxidative stress markers measured in brain tissues with behavioral components\nof the aforementioned model. Thus, it is hereby proposed a possible IBS animal model relevant\nto pharmacological and complementary medicine studies����.....
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