Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 5 Articles
Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery\nsystems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by\nstereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM\nprocess combining SLA with inkjet printing was successfully implemented in an existing SLA test\nsetup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots\nwere generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum\nalbumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside\na DDS. The new hybrid AM process makes it possible to place several drugs independently of each\nother within the matrix. This allows adjustment of the release profiles of the drugs depending on the\nsize as well as the position of the depots in the DDS....
Microparticulated drug delivery systems have been used as promising encapsulation\nsystems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an\nincreased surface to volume ratio, reducing adverse effects, and hence an improvement in\nbioavailability. Among the studied microparticles, there is a rising interest in the research of\nalginate microparticles for pharmaceutical and biomedical fields confirming its potential to be used\nas an effective matrix for drug and cell delivery. Moreover, calcium alginate has been one of the\nmost extensively forming microparticles in the presence of divalent cations providing prolonged\ndrug release and suitable mucoadhesive properties. Regarding the above mentioned, in this research\nwork, we intended to produce Ca-alginate micro-vehicles through electrospraying, presenting high\nencapsulation efficiency (EE%), reduced protein release across the time, reduced swelling effect,\nand high sphericity coefficient. To quickly achieve these characteristics and to perform an optimal\ncombination among the percentage of alginate and CaCl2, design of Experiments was applied.\nThe obtained model presented to be statistically significant (p-value < 0.05), with a coefficient\nof determination of 0.9207, 0.9197, 0.9499, and 0.9637 for each output (EE%, release, swelling,\nand sphericity, respectively). Moreover, the optimal point (4% of alginate and 6.6% of CaCl2) was\nsuccessfully validated....
This study was performed to develop novel core-shell gastroretentive floating pulsatile drug\ndelivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing\nand direct compression method. Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC)-based\nfilaments were fabricated using hot-melt extrusion technology and were utilized as feedstock material\nfor printing shells in FDM 3D printing. The directly compressed theophylline tablet was used as the\ncore. The tablet shell to form pulsatile floating dosage forms with different geometries (shell thickness:\n0.8, 1.2, 1.6, and 2.0 mm; wall thickness: 0, 0.8, and 1.6 mm; and % infill density: 50, 75, and 100) were\ndesigned, printed, and evaluated. All core-shell tablets floated without any lag time and exhibited\ngood floating behavior throughout the dissolution study. The lag time for the pulsatile release of the\ndrug was 30 min to 6 h. The proportion of ethyl cellulose in the filament composition had a significant\n(p < 0.05) effect on the lag time. The formulation (2 mm shell thickness, 1.6 mm wall thickness, 100%\ninfill density, 0.5% EC) with the desired lag time of 6 h was selected as an optimized formulation.\nThus, FDM 3D printing is a potential technique for the development of complex customized drug\ndelivery systems for personalized pharmacotherapy....
This work aims to optimize and assess the potential use of lipid nanoparticles, namely\nnanostructured lipid carriers (NLCs), as drug delivery systems of rifapentine (RPT) for the treatment of\ntuberculosis (TB). A Boxâ??Behnken design was used to increase drug encapsulation efficiency (EE) and\nloading capacity (LC) of RPT-loaded NLCs. The optimized nanoparticles were fully characterized, and\ntheir effect on cell viability was assessed. The quality-by-design approach allowed the optimization of\nRPT-loaded NLCs with improved EE and LC using the minimum of experiments..........................
Given the limited number of materials available to design delivery platforms for nutrients,\nthe rational combination of raw materials already approved as food ingredients and their processing\nthrough nano-micro technology can offer a unique tool for innovation. Here, we propose a nano-in-micro\nstrategy to produce powders based on the hydrophobic protein zein, useful for the oral delivery of\na hydrophilic iron source (iron bisglycinate) in anaemic patients. Iron-loaded powders were prepared\nthrough a two-step strategy consisting in the formation of a zein pseudolatex followed by a spray-drying\nstep. To extend the manipulation space for zein and entrap iron bisglycinate, Beta-cyclodextrin (BetaCD) was\nselected as helping excipient. Addition of BetaCD allowed iron loading in the pseudolatex and greatly\nincreased product yields after the drying process as compared to zein alone. Iron-loaded micro-sized\npowders were characterised by attenuated total reflectanceâ??Fourier transform infrared (ATR-FTIR)\nspectra, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to elucidate the\nrole of BetaCD as a compatibilizer for the zeinâ??iron system. Remarkably, micropowders released only\n20% of FeBIS in a simulated gastric fluid, whereas release in a simulated intestinal fluid was almost\ncompleted in 7 h. In summary, BetaCD association to zein is a novel strategy to expand applications in the\noral delivery of iron bisglycinate and, prospectively, to micronutrient chelates....
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