Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 5 Articles
Background: One of the risk factors of congestive heart failure that still under\ninvestigations is hyperuricemia. Itâ??s still debatable whether itâ??s an independent\nrisk factor or itâ??s just a consequence of other disorders associated\nwith cardiovascular diseases like hypertension, diabetes and dyslipidemia.\nObjective: The aim of our study is to elucidate whether in patients with heart\nfailure serum uric acid level correlates with left ventricular ejection fraction\nsupporting the possibility that the detection of progressive hyperuricemia in\nthese patients may be an indicator of deteriorating cardiac function. Methods:\nWe conducted a prospective study that included 124 studied patients\nand 26 apparently healthy persons at Coronary care unit and Internal Medicine\nDepartment at Sohag University Hospitals. Studied populations were\nclassified into; * Group â??Iâ?: newly diagnosed heart failure, * Group â??IIâ?: decompensated\nheart failure on regular treatment, * Group â??IIIâ?: decompensated\nheart failure but stopped their treatment from three months, Group\nâ??IVâ?: control group, healthy and age-matched subjects. We studied the association\nbetween left ventricular ejection fraction, the severity of congestive\nheart failure and the serum uric acid levels and the well-known conventional\nrisk factors. Results: The main finding was the significantly higher mean serum\nuric acid levels in patients with congestive heart failure versus apparently\nhealthy persons with â??P value = 0.02â?. When we adjusted the serum uric acid\nwith other significant risk factors in the univariate analysis which were age,\ngender and smoking, serum uric acid was an independent risk factor â??P value\n= 0.04â?. There was a significant correlation between serum uric acid level and\nthe severity of congestive heart failure â??P value < 0.001, correlation coefficient\n= 0.35â?. High rates of serum uric acid levels were recorded in patients with\nreduced ejection fraction. A uric acid level of 8.45 mg/dl was found to be the\nmost appropriate cut-off point with the sensitivity 62% and the specificity\n78.5%. Conclusion: Higher serum uric acid levels are significantly correlated\nwith the severity of congestive heart failure and left ventricular ejection fraction.\nSerum uric acid is an independent risk factor for congestive heart failure....
A 34-year-old woman was diagnosed with acute promyelocytic leukemia. Chemotherapy was administered following the JALSG\nAPL204 protocol. Induction therapy with all-trans retinoic acid resulted in complete remission on day 49. She developed\ncoccygeal pain from day 18, which spread to the spine and cheekbones and lasted 5 weeks. She had similar bone pain on days 7â??10\nof the first consolidation therapy and on days 4â??12 of the second consolidation therapy. Oral loxoprofen was prescribed for pain\nrelief. On day 33 of the third consolidation, white blood cell and neutrophil counts were .........................
Background : Evidence of cardiopulmonary resuscitation (CPR) performance\nhas driven interest in procedures, e.g., debriefing to improve CPR quality.\nAim: To investigate retention of skills with and without debriefing 3-months\nafter CPR training on high-fidelity manikins (HFM) among participants involved\nin the â??Heart Safe City Initiativeâ? event (HSCI) in Makkah, Saudi\nArabia. Methodology : A randomized controlled design was used during October\n2017-January 2018. Participants were divided into two groups: an intervention\ngroup to receive debriefing after CPR (debriefing group or â??subjectsâ?),\nand a non-intervention group (â??controlsâ?). Participants were tested repeatedly:\nbefore training (pre-training test), immediately after and 3-months\nafter training (retention or late test); and scores for each test were recorded.\nResults : The studyâ??s subjects and controls did not vary by age, sex, nationality,\nand professionâ??s criteria (p > 0.05, all analyses). The mean retention posttests\nscores significantly varied between subjects and controls [t (df = 200) =\n27.7, p < 0.0001)]; however, the two groups did not vary in their immediate\nscore levels (mean ranks: 106.77 v. 95.68, p = 0.18). Further, the immediate\nposttest scores were significantly higher than the pretestsâ?? within the study\npopulation as a whole group .................................
Background. Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome (ACS). Aortic dissection\nand SCAD share common aetiologies such as a fibromuscular dysplasia (FMD), Marfan, Ehlers Danlos, and more rarely systemic\nlupus erythematosus and Loeys-Dietz; however, SCAD has never been known to have a familial association with aortic dissection.\nCase Summary. This case report describes a 48-year-old woman suffering from SCAD who had a mother who died from ascending\naortic dissection in her 50s. Discussion. This is the first case report to our knowledge of a patient with SCAD with a first-degree\nrelative with aortic dissection. Our case is interesting in that it shows that if predisposition to arterial dissection was inherited\nfrom mother to daughter, one of them suffered an extremely rare manifestation of their underlying disease. It also shows that a\nhigh index of suspicion is needed for SCAD in the presence of a patient with ACS and a family history of dissection elsewhere\nin the arterial tree....
Background. Beta-Thalassemia is a common inherited hemolytic disorder in Palestine. Red blood cell (RBC) transfusion is the principal\ntreatment but it may cause RBC alloimmunization. This study was conducted to determine the prevalence and characteristics of\nRBC alloimmunization among thalassemic patients in northern governorates of Palestine. Methods. A prospective multicenter\nobservational study was conducted in the thalassemia transfusion centers in the northern governorates of Palestine. The study\nincluded 215 thalassemia patients who received regular blood transfusions. Clinical and transfusion records of patients were\nexamined. Antibody screening and identification was conducted using the microcolum gel technique. Results. Two hundred fifteen\npatients were included in the study. More than half (52.1%) of the patients were males. The median age of patients was 18 years\n(range: 12â??24 years). The most frequent blood group was A (40.5%). Alloantibodies were detected in 12.6% of patients. Anti-D\n(33.3%), anti-K (25.9%) and anti-E (14.8%) were the most commonly isolated antibodies. There was no association between age,\nsex, starting age of transfusion, number of transfused units, history of splenectomy and alloimmunization. Conclusions. Anti-Rh\nand anti-K antibodies were common among this cohort of patients. Age, sex, starting age of transfusion, number of transfused units,\nand history of splenectomy could not predict the occurrence of alloimmunization....
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