Current Issue : July - September Volume : 2020 Issue Number : 3 Articles : 8 Articles
Syphilis is a sexually transmitted disease caused by Treponema pallidum. The signs and symptoms of syphilis vary depending on\nwhich of the four stages it presents. The primary stage of syphilis classically presents with a painless ulcer (chancre). We report a\ncase of the extragenital chancre on the nipple which is examined from skin biopsy and immunohistochemistry. This case showed\nthat it is important to identify the special siteâ??s pruritus erythema by pathology and serological examination....
Introduction. Dermatological damage in chronic hemodialysis patients is not uncommon. In Benin, to date, no study on the dermatological\nmanifestations of chronic hemodialysis patients has been carried out. However, the presence of cutaneous signs is evident in\nthese patients, and the need for dermatological care is not negligible. The objective of this study was to identify the epidemiological and\nclinical profile of the main dermatological manifestations presented by chronic hemodialysis patients at the NTH-HKM of Cotonou\n(Benin). Methods. This was a descriptive cross-sectional study conducted in chronic hemodialysis patients from May 15th to September\n15th, 2018. Included were all patients seen during the study period who had been on hemodialysis for at least three months, had at least\none dermatological manifestation, and gave verbal or written consent. Chronic hemodialysis patients who did not wish to participate in\nthe survey were excluded. Results. 87 patients were included in the study for a hospital frequency of 33.8%.The sex ratio (male to female)\nwas 2. The median age was 49 years (IQ [40.75â??59]). Median age in hemodialysis was 36 months with two weekly sessions. The main\ndermatological manifestations were xerosis (48.3%), pruritus (34.5%), alopecia (14%), nail dystrophy (9.2%), equisegmented nails (8%),\nand melanoderma (8%). Pruritus was associated with a longer duration of hemodialysis sessions........................
Background. Cutis laxa is a rare dermatosis that is inherited or acquired and clinically features loose, wrinkled, and redundant skin\nwith decreased elasticity. This heterogeneous connective tissue disorder may be localized or generalized, with or without internal\nmanifestations. Generalized cutis laxa often has a cephalocaudal progression and is attributed to inflammatory cutaneous\neruptions, medications, and infections. Cutis laxa is also associated with several other conditions including rheumatoid arthritis,\nsystemic lupus erythematosus, and plasma-cell dyscrasias. Case Presentation. We report an unusual case of a 35-year-old male\nwith progression of generalized acquired cutis laxa and vasculitis that occurred over a period of one year. No cutaneous inflammatory\neruption preceded or accompanied his decreased skin elasticity, and a biopsy of the skin showed elastolysis. His\ncutaneous manifestation led to systemic evaluation and an eventual diagnosis of smoldering multiple myeloma accompanied by\naortitis and anemia. His myeloma and vasculitis were successfully treated with cyclophosphamide, bortezomib, and dexamethasone\nand high-dose prednisone, respectively, with no improvement to his cutis laxa. Conclusions. The presence of\nmonoclonal gammopathy is strongly associated with several dermatological entities such as acquired cutis laxa. We propose a new\nterm for the dermatological manifestations caused by paraproteinemia: monoclonal gammopathy of dermatological significance,\nor MGODS, and stress the evaluation of an underlying gammopathy in the setting of certain dermatologic conditions, including\nscleromyxedema and amyloidosis. We present a case of a newly acquired cutis laxa secondary to plasma-cell dyscrasias that\nexemplifies MGODS, alongside a brief literature review, and underscore the clinical relevance of monoclonal gammopathies of\ndermatological significance....
Background. Although infliximab (IFX) has been available since 2005, there are very little data on the long-term drug survival of\ninfliximab in real-life. Objective. Our aim was to identify and describe psoriasis patients treated with IFX for longer than 6 years.\nMethods. Psoriasis patients treated with IFX for longer than 6 years were retrospectively included. Demographic and clinical data\nwere collected in May 2018. Results. Between January 2005 and December 2012, 43 patients were maintained on IFX for 6 years or\nlonger. IFX was introduced as a 4.5 line of systemic therapy. The mean duration of IFX treatment was 8.5 years (6â??12). In May\n2018, 30 patients (70%) were still maintained on IFX at 4â??6 mg/kg every 8â??10 weeks with an efficiency of about 100%. IFX was\nstopped in 13 patients (30%) mainly for loss of efficacy in 6 patients (46%). Three patients developed solid cancer including bladder\ncancer, lung cancer, and prostate cancer. Limitation. Retrospective study. Conclusion. We report the efficacy and safety of IFX\nmaintained for up to 12 years in psoriasis patients. Thelong-term use of IFX was associated with a high BMI confirming the critical\nrole of weight-based dosing for this drug....
Background: Atopic eczema is a relapsing, itchy chronic cutaneous inflammatory disease that commonly affects\nchildren. The disease is often complicated by cutaneous infections such as eczema herpeticum, eczema vaccinatum\nand a varied number of bacterial infections â?? impetigo, cellulitis and erysipelas. However, rare case reports of\ninfective endocarditis, otitis media and osteo-articular infections have been associated with atopic eczema. These\nassociations possibly represent the extracutaneous infectious complications of atopic eczema.\nCase presentation: Here we present two cases of osteomyelitis in HIV negative children with habitual scratching\nof poorly managed and/or uncontrolled atopic eczema respectively. Both cases presented to the orthopaedic\nsurgeons and were admitted as acute phalangeal osteomyelitis and acute â?? on â?? chronic tibial osteomyelitis\nrespectively. The first case was an 8 year old girl who had moderate-severe poorly-controlled atopic eczema and\ncontiguously spread phalangeal osteomyelitis. The second case was an 11 year old pre-pubertal boy who had\nuntreated atopic eczema and tibial osteomyelitis possibly from haematogenously spread Staphylococcus aureus\ninfection. Both were successfully discharged from hospital and currently have well controlled eczema. The 11 year\nold patient is also being reviewed monthly by the orthopaedic surgeons and is chronic suppressive antibiotics. He\nmay require sequestrectomy, should it be needed.\nConclusions: Invasive staphylococcal and streptococcal osteo-articular (OA) infection can arise as an extracutaneous\ninfectious complication of poorly controlled atopic eczema. It is more common in the 3 to 15 year age\ngroup and especially in boys with a septic arthritis to osteomyelitis ratio of around 29:5. Clinicians should maintain\na high index of suspicion in patients with moderate-severe atopic eczema and they ought to promptly manage\nthese OA infections with intravenous antibiotics to avoid further complications....
Introduction. Alopecia areata (AA) is a common autoimmune disorder of hair follicles characterized by patches on nonscarring\nhair loss. Reports of prevalence and clinical characteristic of AA in Saudi Arabia are limited. The aim of our study is to describe the\nprevalence and clinical characteristics of Saudi patients with AA. Materials and Methods. A retrospective cross-sectional study was\nconducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. All patients diagnosed with AA between January 2016 and\nDecember 2017 were included. Data included patient demographics, type of AA, disease duration, family history of AA, and\ncomorbid autoimmune diseases. Results. A total of 216 patients with AA were included. The overall prevalence of AA was\napproximately 2.3%. The mean disease duration at the time of presentation was 2 months while the mean age of onset was 25.61\nyears. Themost common type of AA in both adult and pediatric groups was the patchy type involving the scalp. Comorbid diseases\nwere found in 32.41%of patients. Common associated conditions included hypothyroidism, diabetes mellitus, and atopic diseases.\nConclusion.The overall prevalence of AA among a population of Saudi patients is 2.3%. AA prevalence is higher in pediatrics than\nadults. Common comorbid conditions include hypothyroidism, diabetes mellitus, and atopic diseases....
In view of the increasing sensitivity of consumer skin in recent years, cosmetics\ncontaining Artemisia annua extract was tested to evaluate its effectiveness\nin repairing sensitive skin. Through the experiment of xylene-induced ear\nswelling in mice, it was found that the inhibition rates of ear swelling in mice\ninduced by xylene in three groups of cosmetics containing Artemisia annua\nextract reached 60.40%, 73.36% and 74.01%, respectively, close to the positive\ndrug group. Twenty-five sensitive skin volunteers were selected for human\nclinical trial, and the skin TEWL value, cuticle hydration degree and skin\nheme (ultra-high concentration) were tested. The results showed that using\ncosmetics containing Artemisia annua extract for four weeks could effectively\nincrease the hydration degree of cheek cuticle by 63.90% and reduce transepidermal\nwaterloss (TEWL) by 21.51%. The skin heme (ultra-high concentration)\ndecreased by 69.14% and the affected area decreased by 77.47%. The\nresults show that the cosmetics containing Artemisia annua extract can inhibit\ninflammation, repair skin barrier, improve damaged skin, and reduce\nredness and other sensitive skin symptoms....
Morel-Lavallée lesion (MLL) is a degloving injury in soft tissues caused by shear force accompanying trauma. Even if it is a small\nlacrimal wound at the initial visit, there is a range of skin necrosis which is not suitable for it. As a cause of the injury, a shearing\nforce was applied over a wide range, and penetrating blood vessel damage to the skin occurred, resulting in skin necrosis. Attention\nis required....
Loading....