Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
Here, we report a novel thermo-triggered-releasing microcapsule for liposoluble drug\ndelivery. Monodisperse microcapsules with a poly(N-isopropylacrylamide-co-methacrylic acid)\nhydrogel shell and an oil core were successfully fabricated by a double coaxial microfluidic device.\nFluorescent dye Lumogen Red F300 as a model liposoluble drug was dissolved in the oil core with\ncontrollable loading capacity. The volume phase transition temperature (VPTT) of the microcapsule\nwas adjusted by copolymerizing with the hydrophilic methacrylic acid. The in vitro release study\ndemonstrates that the shells shrink, leading to the thermo-triggered release of the model drug from the\nmicrocapsules at the environmental temperature above the VPTT, while the swollen hydrogel shells\ncan protect the encapsulated drug from leakage and contamination below the VPTT. The proposed\nmicrocapsule is a promising liposoluble drug delivery system with controllable loading and smart\nthermo-triggered release....
In the present study, a nanoapatite-mediated delivery system for imatinib has been proposed.\nNanohydroxyapatite (nHAp) was obtained by co-precipitation method, and its physicochemical\nproperties in combination with imatinib (IM) were studied by means of XRPD (X-ray Powder\nDiffraction), SEM-EDS (Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy),\nFT-IR (Fourier-Transform Infrared Spectroscopy), absorption spectroscopy as well as DLS (Dynamic\nLight Scattering) techniques. The obtained hydroxyapatite was defined as nanosized rod-shaped\nparticles with high crystallinity. The amorphous imatinib was obtained by conversion of its crystalline\nform. The beneficial effects of amorphous pharmaceutical agents have been manifested in the\nhigher dissolution rate in body fluids improving their bioavailability. Imatinib-to-hydroxyapatite\ninteractions on the surface were confirmed bySEMimages..................................
This study aims to prepare hybrid chitosan-alginate aerogel microparticles without using\nadditional ionic crosslinker as a possible pulmonary drug delivery system. The microparticles were\nprepared using the emulsion gelation method. The effect of the mixing order of the biopolymer within\nthe emulsion and the surfactant used on final particle properties were investigated. Physicochemical\ncharacterizations were performed to evaluate particle size, density, morphology, surface area,\nsurface charge, and the crystallinity of the preparation. The developed preparation was evaluated for\nits acute toxicity in adult male Sprague-Dawley rats. Measurements of zeta potential suggest that the\nsurface charge depends mainly on the surfactant type while the order of biopolymer mixing has less\nimpact on the surface charge..............................
This study aims to formulate and evaluate nanoparticles containing simvastatin using chitosan as a biodegradable polymer. The simvastatin loaded nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions. Polymeric nanoparticles of various core: coat ratio were prepared and evaluate % product yield, entrapment efficiency, particle size and zeta potential, in-vitro drug release and stability studies. The prepared simvastatin nanoparticles were white, free-flowing and in a spherical shape. The IR spectra showed the stable character of simvastatin within the drug-loaded nanoparticles and displayed the absence of drug-polymer interactions. The chitosan nanoparticles have a particle diameter ranging between 132.1±5.60 to 774.8±2.60 nm and a zeta potential +11.93 to +43.23 mV. The in-vitro release profile from the entire drug loaded formulation batches were found to follow first order and provided a sustained release for 10 h. No considerable difference was observed within the extent of degradation of the product during 90 days during which nanoparticles were stored at different temperatures. The discharge of simvastatin was influenced by the drug to polymer ratio and particle size. These results indicate that simvastatin nanoparticles might be effective in sustaining drug release for a prolonged period....
Chronic wounds are characterized by a localized pH change from acidic (healthy) to\nalkaline (unhealthy), which can be harnessed to act as a switch for drug release from a polymer\nmedium covering the wound for improved healing. To realize this, a new polymer dressing material\nis needed to help heal chronic wounds. Polypyrrole (PPy) is a biocompatible electroactive polymer\nthat has been proven as a successful drug delivery mechanism, but currently lacks the capacity\nfor scalable clinical applications due to its poor processability. In this study, PPy films with and\nwithout microstructures were produced using electrochemical oxidation and subsequently doped\nwith fluorescein, a model drug molecule. To increase the drug loading capacity, microstructures were\ncreated through soft template polymerization of pyrrole around hydrogen gas bubbles. Fluorescein\nrelease was measured using UV spectroscopy over a pH range of 2 to 11, showing increased release\nat higher pH values. Microstructured films showed an increased doping capacity compared to flat\nPPy films, attributed to the increase in drug incorporation sites. The pH-activated release mechanism\nwas shown to be successful and can be applied as a pH-sensitive biosensor and drug delivery system\nin vitro....
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