Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
Chitosan is used in various drug delivery approaches as a pharmaceutical excipient.\nAlthough its potential as an immunomodulatory agent has been reported, its use in this capacity has\nnot been fully explored. The efficacy of chitosan as an active pharmacological agent, particularly\nin anti-inflammatory therapy in inflammatory bowel diseases (IBD), was investigated in this study.\nThe potential impact of the molecular weight (MW) and degree of deacetylation (DD) of chitosan\nwas investigated together with 5-amino salicylic acid (5-ASA) for its efficacy in a combination\nanti-inflammatory therapy in murine experimental colitis. Such a combination would potentially\nbe developed into novel dual strategies whereby chitosan acts as a mucoadhesive excipient as\nwell as provide an additional anti-inflammatory benefit...........................
Felines may find orally administered medicines unpalatable, thus presenting a problem\nin the treatment of chronic conditions such as hypertension, a commonly diagnosed condition in\nfelines requiring daily administration of medication. A pertinent example is amlodipine besylate,\nformulations of which are known to be poorly tolerated by cats. There is therefore a need to develop\nfeline-specific delivery approaches that are both simple to administer and mask the taste of the drug,\nthereby enhancing the ownerâ??s commitment to treatment and the associated therapeutic outcome for\nthe companion animal. In addition, it is helpful to develop accessible and reproducible means of\nassessing taste for pre-clinical selection, hence the use of recently developed taste biosensor systems\nfor veterinary applications is an area of interest. This study focuses on developing feline-specific\namlodipine besylate formulations by improving the taste using a suitable flavouring agent while\nreducing dosage form size to a 2 mmdiameter mini-tablet. The choice of l-lysine as a flavouring\nagent was based on the dietary and taste preference of cats. The impact of l-lysine on the taste\nperception of the formulation was evaluated using a biosensor system (E-tongue) fitted with sensors\nsensitive to bitter tastes. The results showed l-lysine successfully masked bitterness, while the drug\nrelease studies suggest that it has no impact on drug dissolution. In addition, tableting parameters\nsuch as tablet mass uniformity, content uniformity, tablet diameter, thickness and hardness were all\nsatisfactory. The present study suggests that amlodipine besylate mini-tablets containing l-lysine\ncould improve the palatability and in turn support product acceptability and ease of administration.\nThese data could have an impact on orally administered medicines for cats and other veterinary\nspecies through product differentiation and competitive advantage in the companion animal market\nsector. The study also outlines the use of the electronic tongue as a tool for formulation selection in\nthe veterinary field....
This study tested 15 direct compaction grades to identify the contribution of different\ngrades of mannitol to the storage stability of the resulting tablets. After preparing the model\ntablets with different values of hardness, they were stored at 25 DegreeC, 75% relative humidity for\n1 week. Then, measurement of the tablet properties was conducted on both pre- and post-storage\ntablets. The tablet properties were tensile strength (TS), friability, and disintegration time (DT).\nThe experimental data were analyzed using a Kohonen self-organizing map (SOM). The SOM analysis\nsuccessfully classified the test grades into three distinct clusters having different changes in the\nbehavior of the tablet properties accompanying storage. Cluster 1 showed an obvious rise in DT\ninduced by storage, while cluster 3 showed a substantial change in mechanical strength of the tablet\nincluding a reduction in the TS and a rise in friability. Furthermore, the data were analyzed using\nan Elastic net regression technique to investigate the general relationships between the powder\nproperties of mannitol and the change behavior of the tablet properties. Consequently, we succeeded\nin identifying the crucial powder properties for the storage stability of the resulting tablets. This study\nprovides advanced technical knowledge to characterize the effect of different direct compaction\ngrades of mannitol on the storage stability of tablet properties....
In our current research, sucrose palmitate (SP) was applied as a possible permeation\nenhancer for buccal use. This route of administration is a novelty as there is no literature on the use\nof SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures,\nwith different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC)\nchains. The mechanical, structural, and in vitro mucoadhesive properties of films containing SP were\ninvestigated. Tensile strength and mucoadhesive force were measured with a device and software\ndeveloped in our Institute. Positron annihilation lifetime spectroscopy (PALS) and X-ray powder\ndiffractometry (XRPD) were applied for the structure analysis of the films. Mucoadhesive work was\ncalculated in two ways: from the measured contact angle and compared with direct mucoadhesive\nwork, which measured mucoadhesive force, which is direct mucoadhesion work. These results\ncorrelate linearly with a correlation coefficient of 0.98. It is also novel because it is a new method for\nthe determination of mucoadhesive work....
The aim. The aim of the research was to study the effect of different groups of excipients on the pharmaco-technological\npropertiesof the powder mass for tabletting in the development of the composition of the tablets with dry extract of Sanguisorba\nofficinalis for complex therapy of the gastrointestinal tract diseases....
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