Current Issue : April-June Volume : 2020 Issue Number : 2 Articles : 2 Articles
The objective of the present study was to formulate and evaluate of curcumin liquisolid tablets to enhance the dissolution profile of poorly water soluble drug curcumin. Liquisolid formulations were prepared by direct compression method using loading factor (Lf) and retention value (R-value) calculation to get acceptable flowable and compressible powder form. Different curcumin liquisolid formulations (LSF 1 to LSF 3) were prepared by using different non-volatile solvents like propylene glycol, tween-80 and span-80 and their dissolution profile compared with curcumin direct compression tablet. The curcumin liquisolid tablets were within the acceptable limits and drug release rate of all liquisolid tablets were higher than the direct compression tablet. LSF 2 (88.52%) liquisolid formulation shows higher drug release than LSF 1 (85.57%) and LSF 3 (82.62%) formulations. All the preformulation parameters were evaluated such as solubility, melting point, bulk density, tapped density, Hausner’s ratio, angle of repose and Carr’s index. FTIR analysis confirmed no interaction between drug and excipients. Liquisolid formulations showed improved in in-vitro dissolution behaviour of curcumin than direct compression tablet. From this study, it was concluded that liquisolid method is a promising alternative for enhancement of dissolution property of water insoluble drugs....
In this present work, preparation of ganciclovir magnetic microsphere is prepared by phase separation emulsion polymerization method. Magnetic microspheres are mainly used deliver the drug to specific site in the predetermined rate for a long time. The ganciclovir comes under the antiviral drug classification, it is mainly used to treat against cytomegalo virus, hepatitis virus, herpes virus etc. The various evaluation tests are done for the magnetic microsphere containing ganciclovir as loaded drugs are dissolution test, particle size distribution, SEM and FTIR....
Loading....