Current Issue : October-December Volume : 2018 Issue Number : 4 Articles : 6 Articles
The main objective of this experiment was to determine the amount of caffeine in commercial brand soft drinks by means of UV method. This study focus on checking harmful level of caffeine present in soft drinks by comparative study of UV analysis with standard caffeine. Due to alkaloid in nature, caffeine was extracted out by highly organic solvent like chloroform. The liberated caffeine was measured by UV method. Results show that all the soft drinks are highly acidic in nature and have considerable caffeine content which is CNS stimulant and may produce addiction. All consumable products containing added caffeine should be required by the Food and Drug Administration (FDA) to include caffeine quantity on their labels. Currently, no foods or beverages that contain caffeine are required to include caffeine content on their labels....
A simple, rapid, accurate and sensitive UV-spectrophotometric method has been developed and validated successfully for the estimation of mifepristone in bulk and in-house formulation. Using, zero order spectrum of mifepristone was derivatized into first order by software UV Probe 2.21. ‘Method A’ is for zero order derivative and ‘Method B’ is for zero order area under curve (AUC) technique; measured in the wavelength set from 287.00-318.80 nm. While ‘Method C’ is for 1st order derivative and ‘Method D’ is 1st order AUC technique; was measured in the wavelength set from 310.00-338 nm, in which area under curve was integrated in the wavelength set at 323.60 nm. The λmax of mifepristone in methanol was found to be 305 nm. The drug shows linearity in the range from 3-18 µg/ml with r2 value was 0.998. The current method was introduced for qualitative and quantitative estimation of mifepristone in bulk and in-house formulation. This developed method can be used for routine analysis....
Stem bark of Ziziphus xylopyrus, (Retz) Willd. was collected dried, powdered and subjected for extraction. Preliminary phytochemical screening showed the presence of alkaloids, carbohydrates, steroids and sterol, glycosides, saponins, flavonoids, phenolic compounds, triterpenoid in ethanolic and aqueous extracts of stem bark of Ziziphus xylopyrus, (Retz) Willd. Fractions were prepared according to polarity. TLC, HPTLC, UV, HPLC, IR, NMR and mass spectroscopy carried out. Tri-terpenoids Lupeol has been isolated from stem bark of Ziziphus xylopyrus, (Retz) Willd and their structure determined by spectral data chemical data. The results of the study can serve as a valuable source of information and provide suitable standards for identification of this plant material in future investigation and application. It was determined and isolated from the stem bark of Z. xylopyrus for the first time....
Nowadays regulatory science based pharmaceutical development and product manufacturing is highly recommended by the authorities. The aim of this review was to study regulatory science even in the nano-pharmaceutical early development. Advancing nanomedicines from concept to clinic requires integration of new science with traditional pharmaceutical development. The medical and commercial success of nanomedicines is greatly facilitated when those charged with developing nanomedicines are cognizant of the unique opportunities and technical challenges that these products present. These individuals must also be knowledgeable about the processes of clinical and product development, including regulatory considerations, to maximize the odds for successful product registration. A risk assessment was performed with various process and formulation parameters to determine their impact on particle size and encapsulation efficiency (CQAs) of nanomaterials. In the present review basic consideration of the QbD approach, its historical background and regulatory needs are discussed. In detail explanation of elements of QbD i.e. method intent and risk assessment is given. Application of QbD to pharmaceutical and biopharmaceutical processes, development and unit operation associated with it are briefly mentioned....
Naproxen sodium is a drug used to relieve pain, fever, swelling and stiffness. It works by inhibiting COX-1 and COX-2 (Cyclooxygenase 1 and 2) enzymes which inhibits prostaglandin synthesis. Prostaglandins act as signalling molecules in the body, inducing inflammation. Thus, by inhibiting COX-1/2, naproxen induces an anti-inflammatory effect. For the determination of naproxen sodium in pharmaceutical dosage form and bulk form, several analytical methods including LC-MS, GC-MS, HPTLC, UV, HPLC and other methods has been developed. Methods indicating human plasma, stability and impurity profiling are also described for naproxen. For qualitative and quantitative estimation of naproxen these analytical methods can be used and it can also be used for its related degradants in bulk formulations and biological fluids. The following study depicts the review on analytical methods which includes estimating the propionic acid derivative, naproxen....
Forced degradation studies were performed for prasugrel and aspirin on four different stress conditions in pharmaceutical dosage form by using validated spectrophotometric method. Degradation studies reveal the method capability on different stress condition. Absorption maxima was found to be 254.4 nm, 225.6 nm was for prasugrel and aspirin respectively without mutual interference. Isobestic point for both drugs was chosen at 238.4 nm. This method obeyed Beer’s law in the concentration range of 10-70 μg/ml for prasugrel and 2-26 μg /ml for aspirin. The results of the analysis have been validated statistically. Method proven to be rapid, precise and cost effective for the routine analysis in pharmaceutical dosage form....
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