Current Issue : July-September Volume : 2018 Issue Number : 3 Articles : 3 Articles
As one third of the world’s population is infected with M. tuberculosis along with this new and relapse cases of tuberculosis are reported every year. The emergence of new cases, increased incidence of multi-drug resistant strains of M. tuberculosis and the side effects of existing first- and second-line antituberculosis drugs have led to hope of discovering new antitubercular drug molecules. The increase in demand for the synthesis of new antitubercular agents is due to the developing resistance towards existing drugs. The present review explores active triazole, thiazolidine, pyridine, oxazolidinone derivatives having antitubercular activity published during the last 10 years. Also, critical aspects of structure activity relationship with respect antitubercular activity have been encompassed. The present endeavor will of cognitive importance for further research on the potential use of said heterocyclic nucleus towards anti-tubercular activity....
A series of novel flavanone incorporated semicarbazide derivatives (Y2a–Y2j) was synthesized and characterized by elemental analyses, 1H NMR, IR and mass spectral studies. All the newly synthesized compounds (Y2a- Y2j) were screened for anti-phlogistic (anti-inflammatory) and anti-nociceptive activities against paw edema method, cotton pellet-induced granuloma, formalin induced paw edema in rats and acetic acid-induced writhing test respectively and compared with the standard drug diclofenac sodium and aspirin and compounds Y2c (o-NO2), Y2f (p-OH), Y2g (p-N(CH3)2) and Y2j (p-OH,-m-(OCH3)) having more anti-inflammatory and analgesic effect as compare to Y2a (p-Chloro), Y2b (o-Chloro), Y2d (m-NO2), Y2e (p-NO2), Y2h and Y2i (o-OH) and antimicrobial activity were also tested for their anti bacterial activity against gram positive bacteria S. aureus and B. antracis while gram negative bacteria P. aeruginosa and E. coli. And same compounds were tested for their anti fungal activity against C. albicans and A. Niger using cup plate method. Streptomycin, erythromycin, fluconazole and ketoconazole were used as a reference compound. The entire compounds shown good activity against gram positive and gram negative bacteria. The compounds Y2a (p-Chloro), Y2b (o-Chloro), Y2d (m-NO2), Y2e (p-NO2), Y2h and Y2i (o-OH) show moderate activity while Y2c (o-NO2), Y2f (p-OH), Y2g (p-N(CH3)2) and Y2j (p-OH,-m-(OCH3)) show good anti fungal and anti bacterial activities....
In chemical kinetics, the rate and mechanism of a chemical reaction is to determine the overall stoichiometry of the reaction and to identify any side‐reaction. This study involves the determination of the effect of changes in the concentrations of reactant and product species. One reason for studying the rates of the reaction is to predict how quickly a reaction mixture approaches equilibrium. Another is that the study of reaction rates leads to an understanding of the mechanism of a reaction and analysis into a sequence of elementary steps. The kinetics study on oxidation of benzaldehyde and p-nitro benzaldehyde has been investigated at 313 K by isoquinolinium bromochromate in aqueous acetic acid medium. The reaction is first order with respect to [IQBC], [substrate] and [H+]. The benzoic acid was identified as end - product by existing standard methods. The stoichiometric determination confirms 3:1 mole ratio of substrates - IQBC system. Activation parameters were evaluated and suitable mechanism was proposed. The rate law in consistent with the observed kinetic results have been discussed. This work can better and suitably be utilized in drugs and pharmaceutical industries and also in soft drink or cold drink industries....
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