Current Issue : April-June Volume : 2019 Issue Number : 2 Articles : 2 Articles
The present study was aimed at development of gastroretentive floating microspheres of nicardipine for controlled release and to develop innovative and suitable dosage form by the use of various polymers. Nicardipine is an antihypertensive drug it is a dihydropyridine calcium-channel blocking agent used to treat the vascular disorders such as chronic stable angina, hypertension. Different floating microspheres formulations were prepared using different polymers like locust bean gum, gellan gum, Eudragit S 100, Eudragit L 100, sodium alginate in various combination ratios by ionotropic gelation method. All the developed formulations were subjected to various evaluation parameters such as particle size, micromeritic study, percentage yield, drug entrapment efficiency, in-vitro buoyancy, swelling index, floating behaviour, in-vitro drug release scanning electron microscopy (SEM) and stability studies. Optimized formulation was decided based on drug release studies, buoyancy studies, percentage yield, gastro retention time, swelling index, zero order, first order, Higuchi model, korsmeyer peppas model. Formulation containing sodium alginate and locust bean gum in combination (F3) exhibited maximum drug release of 97.33% for 12 hrs and scanning electron microscopy (SEM) revealed smooth surface characteristics with less particle size and good flow properties hence it was confirmed as the optimized formulation....
Sublingual tablets of Carvedilol phosphate were prepared to improve its bioavailability, to avoid pre-systemic metabolism in the gastrointestinal tract and hepatic first pass elimination. The Sublingual tablets were prepared by direct compression procedure using different concentration of F-Melt, Beal Fruit Gum and microcrystalline cellulose. Compatibility studies of drug and polymer were performed by FTIR spectroscopy and DSC. Preformulation property of API was evaluated. Post compressional parameters such disintegration time, wetting time, water absorption ratio, in-vitro drug release and in-vivo bioavailability study of optimized formulation were determined. FTIR spectroscopy and DSC study revealed that there was no possible interaction between drug and polymers. The precompression parameters were in acceptable range of pharmacopoeial specification. The disintegration time of optimized formulation (F7) was upto 25 sec. The percentage relative bioavailability of carvedilol phosphate from optimized sublingual tablets was found to be 98.48%. Sublingual tablets of carvedilol phosphate were successfully prepared with improved bioavailability....
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