Inventi Rapid: Molecular Pharmacology

Inventi:prmp/27944/21

Restorative Potential of Curcumin in Parkinson’s Disease Therapeutics

Parkinson’s disease (PD) is an age-associated neurodegenerative disease clinically called as a movement disorder. The PD is characterized by selective degeneration of dopaminergic neurons in the substantia nigra which is part of the midbrain thereby depleting the dopamine levels in the striatum and leads to several motor symptoms. Most of the current pharmaco-therapeutic approaches available now days focused on replenishing the striatal dopamine level but none of them able to halt disease progression. However the current available therapy provides symptomatic relief during early PD, long-term treatment with anti-parkinson’s drugs develop motor complications in pakinson’s patient. Over the last 20 years curcumin has been reported to be effective against a wide variety of diseases and is characterized as having anticarcinogenic, hepatoprotective, anti-oxidant, mutagenic, anti-inflammatory, cardioprotective, antiarthritic and anti-infectious properties. Till the date now, curcumin is evaluated in different experimental models of PD which strongly support the clinical application of curcumin in PD. The current regimens are hampered by therapeutic limitations and with certain adverse affects; thus, there is a need to develop novel and more effective drugs with fewer side effects. The aim of this review article is to discuss the potentiality of curcumin in PD over the last 20 years with neuroprotective properties against the neurodegeneration involved in PD....