Current Issue : January-March Volume : 2017 Issue Number : 1 Articles : 2 Articles
Extended release parenteral dosages forms have been successfully used for the treatment of a variety of diseases. To assure the performance and safety of these products, the development of a suitable in-vitro release testing method is crucial. A single approach should not be set for in-vitro release testing given the wide range of controlled release parenteral products; they noted a need for general guiding principles and encouraged research to ensure a scientific basis for the development of different tests, procedures and acceptance criteria. In the pharmaceutical industry, dissolution testing is a very important tool in drug development and quality control. Understanding the factors influencing drug release, both from an in-vivo and an in-vitro perspective, is essential for the development of meaningful in-vitro release tests and performance specifications. At present, there is a lack of standard pharmacopeial/regulatory tests for controlled release parenteral products and this poses a major obstacle in their development and regulatory processes. The aim of this review is to provide the reader with a brief description on factors accelerating in-vitro drug release followed by current accelerated in-vitro release testing methods for parenteral dosage forms....
In present study a relatively simple method for the separation of husk from the seed of Trigonella-foenum graecum (Fenugreek) was developed. The entire seed were subjected to size reduction followed by successive extractions with chlorinated hydrocarbons to separate the husk from the ââ?¬Ë?core and oily portionââ?¬â?¢ to yield about 40% w/w of the husk .The dried husk was further powdered to 180-250Ã?µ.It was characterized for various physiochemical parameters including swelling index, Particle size distribution and flow properties .Use of fenugreek husk as a binding /granulating agent in the formulation of Azithromycin tablet. Azithromycin were the model drug of choice for optimizing the binding properties of husk in formulation of Azithromycin tablet. In present investigation results of fenugreek husk dispersion, comparing against starch paste. Friability, hardness, disintegration, Weight variation and dissolution were the parameters of comparative studies. Fenugreek husk dispersion was found to be superior over starch paste, on the basis of the selected parameters. The maximum concentration required of the husk as a binding agent was 4-5%, which is relatively low as compared to starch....
Loading....