Current Issue : October-December Volume : 2015 Issue Number : 4 Articles : 1 Articles
Diabetes mellitus (DM) is a progressive disease characterized by hyperglycemia due to insulin deficiency and insulin resistance or both. Owing to the progressive nature of the disease, an evolving treatment strategy is necessary to maintain glycemic control inhibitors. Glycogen synthase kinase-3β (GSK-3β) is a unique multifunctional serine/threonine kinase that is inactivated by phosphorylation in response to insulin binding; PKB/AKT phosphorylates GSK-3β on serine 9, which prevents the enzyme from phosphorylating glycogen synthase. We tried to prepared the analogs in which keeping the hydantoin ring and substitution at C-9 or C-10 positions apart from this hydantoin ring is replaced with bioisosteric substitute ring (like rhodadine, oxindole) can afford potent and selective GSK-3β inhibitor. In the present research work, an attempt has been made to synthesized phenyl methylene hydantoin derivatives, which are expected to have antidiabetic activity. Phenyl methyl hydantoin analogs were synthesized and their activity shows their potency. Some novel GSK-3β were designed and synthesized....
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