Current Issue : July-September Volume : 2016 Issue Number : 3 Articles : 1 Articles
Sustained release products are designed to release their medication in a controlled manner, at a predetermined rate, duration and location to achieve and maintain optimum therapeutic blood levels of drug. In case of simple matrix tablet, use of drug with high water solubility is accompanied by problems, i.e. relatively large amount of release-delaying agent is needed and the size of tablet as well increases in proportion to that, effecting the cost of production. Therefore, recent studies have been conducted to modify surface properties of drug at molecular level. According to said preparation methods, as drug surface can be covered with hydrophobic substances at particulate or molecular level, release-delaying can be effectively induced by use of just small amount of hydrophobic additive and the process is simple. However, majority of the hydrophobic additives used in melt granulation and melt extrusion has property of wax, thus the surface of particles prepared by cooling after melting becomes to exhibit adhesion toward another surface. The present study was conceived to resolve the problems of the conventional techniques and its object lies in minimizing the amount of hydrophobic additives for imparting sustained-releasing property and eliminating adhesion phenomenon of granules occurring during the tablet preparation....
Loading....