Current Issue : October-December Volume : 2015 Issue Number : 4 Articles : 3 Articles
Aceclofenac is a non steroidal anti-inflamatory drug, active against arthritis to relive pain and inflammation. The main objective of this research work was to prepare ethyl cellulose microspheres loaded with aceclofenac and in-vitro drug release study. In the present study, emulsion solvent evaporation method is used for preparing microspheres. The polymer (EC) and drug (aceclofenac) was dissolved in acetone. Surfactant was added to this solution and stirred it for 30 min. The oil and 1 drop of span‐80, span-20, tween 80, tween 20 (as emulsifier) were mixed together and allowed to stir for 2 hrs at 800‐1000 rpm. The aqueous phase was added to oil phase to form primary emulsion. This emulsion was stirred for 3 hrs at 800‐1000 rpm. Microspheres were filtered and dried in dessicator over night. Microspheres were spherical shape and smooth surface. Infra‐red spectra showed identical peaks of drug and polymer drug entrapment efficiency was 92% determined by UV‐ spectrophotometer at 274 nm. In-vitro drug release studies were performed using USPII Dissolution Apparatus. The formulation EC Showed 88.5% drug was released in 10 hrs. It is concluded that EC microspheres of aceclofenac can be prepared by emulsification solvent evaporation method and in-vitro release data is satisfactory with an aim to develop sustained release matrix tablets (SRMTs) of aceclofenac, which prolongs the release of drug that is released/ dissolved and also aimed to reduce gastric irritation by preparing microspheres of aceclofenac. And then the tablets are prepared by direct compression method to increase the sustained activity and to reduce the dosing frequency. The formulation showed 92.25% drug was released in 24 hrs. The prepared tablets were evaluated for pre and post compression parameters, drug content, in-vitro dissolution studies and stability studies....
The objective of this study was to formulate and evaluate the moulded jelly containing herbal medicament and to optimize the formulation for have beneficiary learning and memory enhancing effect without any side effects. In the present experimental study the hydroalcoholic extract of Bacopa monniera (Brahmi) drug was complexed with beta-cyclodextrin for their taste masking and then formulated into jelly using natural gelling agent pectin with varying concentration. The total eight formulations (F1-F8) were prepared and it shows properties like appearance, pH and viscosity. According to ICH guidelines, F6 batch was found to be optimized and the formulation of F6 was found to be stable for about 1 month....
QbD is a significant tool, to produce optimized quality product, in pharmaceutical industry. It is a continuous process, of building consistent quality products. It consists of several factors such as Target product Profile (TPP), Critical quality attributes (CQA). Design space is one of the important approach, to ensure the quality product through interacting critical process parameters. It emphasizes the interactions, of various inputs in various dimensions. It further leads to, establishment of design space to perform design of experiment (DOE) which includes interactions of various input variables and is based upon prior knowledge. It is dependent upon equipment design, principal and batch size. The control space or normal operating ranges are lower and higher limits of critical raw material attribute and process parameters. The control space should be within design space. The overall approach toward process characterization involves three key steps. First, risk analysis is performed to identify parameters for process characterization. Second, studies are designed using design of experiments (DOE), such that the data are amenable for use in understanding and defining the design space. And third, the studies are executed and the results analyzed to determine the importance of the parameters as well as their role in establishing design space....
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