Inventi Rapid: Pharm Tech

Inventi:prpt/15361/21

Formulation and Evaluation of New Effervescent Tablet of Famotidine for Peptic Ulcer Therapy

Famotidine has been the most widely used drug for the treatment of peptic ulcer for many decades. The present investigation concerns the development and evaluation of fast dissolving effervescent tablet with prior to its solubility of famotidine was enhanced by solid dispersion using spray drying technique to increase drug bioavailability and target the gastric ulcer. The solid dispersion of famotidine was formulated by using hydrophilic polymer like Kollidon VA 64 with their drug –polymer molar ratio as 1:1, 1:3, and 1:5. From DSC and PXRD data clearly shows that crystallinity of famotidine is decreased at certain drug polymer ratio. SEM images also shows that changes in the surface morphology of famotidine due molecular level dispersion of drug in solid dispersion. Among all prepared solid dispersion system which contains 1:3 ratios of famotidine and Kollidon VA 64 has shows 4.5871 (mg/ml) increases solubility than pure famotidine 1.4111(mg/ml). Fast dissolving effervescent tablets of optimized solid dispersion batches were prepared by using citric acid, effersoda, ludipress LCE with direct compression technique. The prepared effervescent tablets were evaluated for precompression and post compression characteristics. The response surface plots were presented graphically to represent the effect of independent variable on the hardness, disintegration time, and friability. An improved therapeutic objective can be obtained by formulating effervescent tablet of famotidine that may help in obviating the disadvantages of slow release and slow absorption and forms a palatable preparation. Finally the tablet formulations found to be economical and may overcome the draw backs associated with the drug during its absorption....