Current Issue : January-March Volume : 2014 Issue Number : 1 Articles : 4 Articles
Bi-layered tablet provide one of the important design approaches to achieve controlled delivery of different drugs with pre-defined release profiles where incompatible drugs, drugs with different indication, and same drug with different release rate can be incorporated in a single unit. Bilayered tablet can be a primary option to avoid physical and chemical incompatibilities between APIs by physical separation, and to enable the development of different drug release profiles like immediate release with extended release property. Generally the pharmacokinetic profile of active drug molecule relies on the fact that the fast release layer provide the loading dose of drug and the sustained release of drug maintain the drug concentration within therapeutic window for longer period of time. Several pharmaceutical companies are currently developing bilayered tablets for a variety of reasons like good therapeutic indication, patient compliances and conventional dosage as compare to other dosage forms. Despite their advantages, due to the use of different materials and complex geometric boundaries between the adjacent layers, the mechanical structures of this drug delivery system have become quite intricate, requiring complicated tablet architectures. This article explains why the development and production of quality bilayer tablet needs to be carried out, the advantages, disadvantages and different methods of formulation as well as study of tablet presses to overcome common bi-layer problems, such as cross-contamination between the layers, layer-separation, individual layer weight control, insufficient hardness etc. for bilayer tablets....
Mouth Dissolving Film is the promising approach for most of the drug delivery. MDF�s is the newer type for drug delivery through which many types of drugs such Anti-Hypertensive, Cough-Cold remedies and many more drugs can be delivered. MDF�s are generally consisting of different synthetic as well as natural polymers. Present review enlightens the advantages of MDF such as it is more preferable in pediatric and geriatric patients. As it does not require any liquid supplements to take with it, it increases the patient compliance and so more suitable over other conventional dosage forms. This review describes the methods of preparation and formulation considerations for effective MDF formulation development. It also includes the quality control evaluation for the same....
The aim of present work is to formulate and evaluate the powder of dried fruit rind of Garcinia indica as Nano-suspension, to improve of poor aqueous solubility. The suitable compositions of Nano-suspension formulation was screened via solubility studies of Garcinia indica in different solvents and tendency of the additives (HPMC & Sodium Alginate) as thickening and suspending agents to prepare oral suspension in various proportions of excipients. These two variables with different concentration were selected, in addition to the Tween 80 as a non-ionic surfactant (less oral irritant) as well the addition of preservative Propylene Glycol, Phosphate Buffer to adjust the formula�s pH in the GIT to prepare the suspension batches. Finally the evaluation of these batches for % Drug release,, Sedimentation volume, viscosity (cp) and Re-dispersibility and for the Nano-suspension was the particle size and particle charge to select the optimize formula and administered as oral suspension of Garcinia indica which is used widely in treatment of varieties of disorders as anti-oxidant, anti-inflammatory and anti-cancer , the selection of a specific action depends on the Pre-clinical and Clinical Trial to exert its action in medicinal field....
The purpose of this research was to formulation, optimization and in vitro evaluation of floating bioadhesive tablets of 5-Fluorouracil (5-FU) anticancer drug. The main objective of the present study was to increase the gastric retention for prolonging the release of drug. A drug delivery system for anticancer drug 5-FU was developed utilizing both the concepts of Floatation and Bioadhesion, in order to obtain a unique drug delivery system which could remain in the stomach for a longer period of time. For the development of floating bioadhesive tablets used polymers like HPMC K15M and Carbopol 934P as a bioadhesive polymer with gas generating agents.. The formulation was optimized by 32 factorial design which was employed to study independent variable X1 (concentration of CP 934P) and X2 (concentration of HPMC K15M) and dependent variables as Y1 (floating lag time), Y2 (% swelling index at 10 hr) and Y3 (cumulative % drug release at 12 hr). The optimized batch showed the optimum floating lag time 26.67�±1.53 seconds, bioadhesive strength 21.96�±0.08 gm/cm2, % swelling index at 10 hr 74.78�±1.22 and cumulative % drug release at 12 hr 90.18�±0.17. Thus the floating bioadhesive tablets were successfully formulated to obtain gastric retention as well as controlled release of the drug.\r\nKey Words: 5 Fluorouracil, Gastric retention, HPMC K15M, Carbopol 934P etc....
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