Current Issue : April-June Volume : 2013 Issue Number : 2 Articles : 4 Articles
Many natural plant products like gum, mucilage,starches etc are used as pharmaceutical excipients for design of formulations. The seeds of Phaseolus mungo & Phaseolus roxburghi have been taken for isolation of excipients and evaluation was carried out by different methods including Phytochemical analysis and Analytical study. Characterization of isolated excipients was done with different parameters like absorption capacity, solubility etc .All results lies within the limits for modification or design of dosage form....
Taro has been reported to have 70–80% starch with small granules, Because of the small sizes of its starch granules, taro is highly digestible. On the basis of current evaluation of properties of starch it has been found that taro starch can be utilized as a better disintegrant as compared to the other traditional starches, Starches are used since a long time as exipients in pharmaceutical preparations. Mainly maize starch, potato starch and wheat starch are used and monographed in several pharmacopoeias. The classical functionalities of native starches in the past are fillers and disintegrants in tablets and fillers in dermatological powders. Also modified (pregelatinized) starches have been used as filler-binders in tablet technology. After this research activity Taro starch can be introduced in the pharmaceutical field and further more research can be done over this starch to make it highlighted in the arena of pharmaceutical research. In addition to food use, taro has found some industrial applications. The very small size of taro starch granules makes them ideal in cosmetic formulations like face powder and in dusting preparations which use aerosol dispensing systems. In spite of the above uses, the large-scale extraction and utilization of this starch is not practised anywhere. So after this research activity the taro starch can be brought to the minds of researchers and it can gain attention in the field of pharmaceutical research....
Excipients are additives used to convert active pharmaceutical ingredients into dosage forms suitable for administration to patients. Excipients from natural products are also generally non-polluting renewable sources. As herbal excipients are non-toxic and biocompatible, they have a major role to play in pharmaceutical formulation. Natural excipients are primarily used as diluents, binders, disintegrants, adhesives, glidants and sweeteners in conventional dosage forms like tablets, capsules etc. Starch, cellulose derivatives, alginate, pectin, acacia, tragacanth, guar gum are used for formulation of conventional and sustained release tablets. It is now recognized that excipients can potentially influence the rate and/or extent of absorption of a drug. Pharmaceutical scientists have shifted their focus to designing a drug delivery system for herbal medicines using a scientific approach. Advancement in polysaccharides, gums and volatile oils has been made to formulate the novel drug delivery system. Legumin and agarose for micro and nanoparticles, Xyloglucan for fabrication of ophthalmic hydrogels have been studied by investigators to realize the potential of herbal excipients and have ended with promising outcomes. Therefore, down the line, herbal excipients will have a lion share in formulation of user friendly and efficacious pharmaceutical formulations and are expected to largely improve and lead to value addition to pharmaceutical formulations and novel drug delivery systems....
Atenolol is a cardioselective β-blocker widely used in hypertension. Atenolol is poorly absorbed from the lower gastrointestinal tract and the oral bioavailability of atenolol was reported to be 50 %. The short biological half life of drug (6 to 8 h) also favors development of controlled release formulations. The result of the present study demonstrated that the okra gum obtained from the fruit of plant Abelmoschus esculentus is light green coloured powder which is amorphous in nature. Drug release from the prepared tablets was slowed over 12 h and depended on the composition of okra gum. Atenolol release was diffusion controlled and followed zero order kinetics. Non-fickian diffusion was the drug release mechanism from the prepared atenolol controlled release tablets. Therefore Okra gum is an efficient release retarding polymer for controlled release tablets....
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