Current Issue : July-September Volume : 2014 Issue Number : 3 Articles : 6 Articles
Benzimidazole derivatives play very efficient role in the medical field with plenty of useful therapeutic activities like antiviral, anti-histaminic, anticancer, antiulcer, antihypertensive, antidiabetic, antifungal, and antimicrobial activity. Benzimidazole is outstandingly effective compounds and there are a number of reviews available for biochemical and pharmacological studies which confirmed that these molecules are useful against a wide variety of microorganisms. Benzimidazole and its derivatives have been showing hopeful activity in the treatment of several diseases, for these reasons, they achieved much attention as important pharmacophore and privileged structure in medicinal chemistry. This review critically provides a broad view of anthelmintic activity possessed by benzimidazole and its derivatives that were reported in the past years....
Objective: To characterize and antimicrobial activity of the piperidine-4-one derivative by using FT-IR, 1H-NMR, 13C NMR, Mass spectroscopy and zone of inhibition. Method: Disc diffusion method-Estimate the antimicrobial activity by using zone of inhibition at two concentrations by disc diffusion method. Results: The compound DALIL1 was found highly potent anti-bacterial activity against bacillus substillis and antifungal activity against candida albicans as compared with standard. Conclusion: the piperidine 4 one derivative were characterized by IR, NMR(both proton and C13) and MASS spectrum. The compound exhibited promising anti-bacterial and anti-fungal activity at both concentrations....
There has been considerable interest for medicinal chemist in development of a promising target for new drug development. Bisphosphonic acid and chalcone are pharmacophores having diverse biological activity. Considering this biological importance of bisphosphonic acid and chalcone nucleus, both are very good anti-inflammmatory agents. Thus it was aimed to synthesize a new target which comprises both the nucleus and screen them for anti-inflammatory activity. We have synthesized new bisphosphonic acid derivatives (PMC 103A-103D) using substituted acetophenones (4-OCH3, 2-Cl, 3-NH2, 3-NO2). The synthesized compounds were confirmed by physiochemical and spectral data. All new compounds were screened for anti-inflammatory activity. Among all synthesized compound PAM 103D shows good inhibition. New moieties contain two pharmacophore bisphosphonic acid and chalcone. Due to presence of two pharmacophore synergism in anti-inflammmatory activity is obtained. Both pharmacophore have diverse biological activity therefore in future this moiety can reveal some other biological activity....
There has been considerable interest for medicinal chemist in development of a promising target for new drug development. Bisphosphonic acid and chalcone are pharmacophores having diverse biological activity. Considering this biological importance of bisphosphonic acid and chalcone nucleus, both are very good anti-inflammmatory agents. Thus it was aimed to synthesize a new target which comprises both the nucleus and screen them for anti-inflammatory activity. We have synthesized new bisphosphonic acid derivatives (PMC 103A-103D) using substituted acetophenones(4-OCH3,2-Cl, 3-NH2,3-NO2).The synthesized compounds were confirmed by physiochemical and spectral data. All new compounds were screened for anti-inflammatory activity. Among all synthesized compound PAM 103D shows good inhibition. New moieties contain two pharmacophore bisphosphonic acid and chalcone. Due to presence of two pharmacophore synergism in anti-inflammmatory activity is obtained. Both pharmacophore have diverse biological activity therefore in future this moiety can reveal some other biological activity....
Heterocyclic compounds are widely distributed in nature and are essential for life. Many heterocyclic compounds due to their specific activity are employed in the treatment of many diseases. Heterocyclic compounds exhibit variety of biological activities. Benzothiazoles are well established in literature as important biologically active heterocyclic compounds. Benzothiazoles play a leading role in the treatment of a variety of bacterial and fungal infections. Benzothiazole contain a phenyl ring fused at 4,5 position of thiazole moiety. Thiazole is the biologically active part of benzothiazole moiety. In the present work, a series of some new substituted benzothiazole derivatives (IVa-IVl) were synthesized from substituted benzophenone (IIa-IIb) in the presence of substituted 2-aminobenzothiazoles (Ia-If) using acetonitrile as solvent. All the synthesized compounds were characterized by TLC, melting point determination, IR, 1H NMR and mass spectral studies. All the synthesized compounds were screened in-vitro for their antibacterial and antifungal activity against representative strains of potent pathogenic bacteria (Staphylococcus aureus and Escherichia coli) and fungi (Aspergillus niger and Candida albicans). Some of the compounds displayed pronounced biological activity...
Pyrazolone is a ketone derivative of pyrazole having anti inflammatory, analgesic, antipyretic effect. Pyrazolone is a five-membered lactom ring compound contacting two nitrogen and ketone in the same molecule. Pyrazolones are well established in literature as important biologically active heterocyclic compounds. Pyrazolone in the class of nonsteroidal anti-inflammatory agents used in the treatment of arthritis and other musculoskeletal joint disorder. The objective of present study was, to synthesize the pyrazolone derivatives and to evaluate them for their anti-inflammatory activity. In the present work, a series of some pyrazolone derivatives (IIIa-g) and (IVa-g) were synthesized, characterized by TLC, melting point determination, IR, NMR and mass spectra and evaluated for their anti-inflammatory activity by in-vitro method using aspirin as a standard drug and antibacterial activity by using ciprofloxacin as a standard drug....
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