Current Issue : April-June Volume : 2012 Issue Number : 2 Articles : 5 Articles
A series of 1,3,4-oxadiazole derivative were synthesized as bactericidal agents. The newly synthesized compounds were then characterized by spectral and elemental analysis. The synthesized compounds were screened for their antibacterial activity against S.aureus and E.coli. All compounds carrying 1,3,4-oxadiazole moiety showed significant biological activity....
Pyrazolines are well known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. Numerous pyrazoline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. They have several prominent effects, such as antimicrobial, antimycobacterial, antifungal, antiamoebic, anti-inflammatory, analgesic, antidepressant and anticancer activities. They also possess some potent receptor selective biological activity like Nitric oxide synthase (NOS) inhibitor and Cannabinoid CB1 receptor antagonists activity. 4,5-dihydro-1H- pyrazolines seem to be the most frequently studied pyrazoline and pyrazolone type of compounds. As a result, a large number of such pyrazolines using different synthetic methods for their preparation have been described in the chemistry literature. The present review provides an insight view to pyrazolines synthesis and its biological activities....
7-methyl carbazole-4-one undergoes condensation reactions with semicarbazide hydrochloride, thiosemicarbazide, 2-aminothiazole and 2-aminobenzthiazole to give bidentate N,O and N,S donor (E)-N-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)thiazole-2-amine [MCT], (E)-N-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)benzthiazole-2-amine [MCB], (E)-2-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)hydrazine carbothioamide [MCCT], (E)-2-(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-ylidene)hydrazine carboxamide [MCCX] Schiff base ligands. These bidentate Schiff bases formed complexes by reacting with cadmium salt. Structures of these Schiff bases and their complexes have been determined on the basis of their physical, analytical and spectral data. The screening result of these compounds indicates that they possess excellent antibacterial as well as antifungal activity against tested pathogenic organisms E. coli, B. Subtilis, A. niger and A. Flavus. However in comparison their metal chelates have been shown to possess more antibacterial and antifungal activities than the uncomplexed Schiff bases....
4-chlorophenoxy acetic acid (2) was prepared by condensation of phenol with monochloroacetic acid. Compound (2) was refluxed with ethanol in the presence of HCL gas yielding ethyl (4-chlorophenoxy) acetate (3). Compound (3) was refluxed hydrazine hydrate in ethanol which produced 2-(4-chlorophenoxy) acetohydrazide (4). Schiff bases were synthesized by the reaction of substituted aldehydes with 2-(4-chlorophenoxy) acetohydrazide (4) in presence of ethanol. These Schiff bases on reaction with acetic anhydride gave the corresponding 3-acetyl-2,3-dihydro 1,3,4-oxadiazole (5a & 5b).synthesized compounds were characterized on the basis of TLC monitoring , melting point, spectral and analytical data. All the compounds screened for antimicrobial and antifungal activity....
A series of substituted 5-phenylpropenylidene-2,4-thiazolidinediones was synthesized by the condensation of different substituted benzalacetones and substituted cinnamaldehydes with 2, 4-thiazolidinedione by Knoevenagel reaction. The antioxidant activity of synthesized compounds was determined by using nitric oxide scavenging method. The synthesized compounds were found to have excellent anti-oxidant activity when compared to standard, vitamin-C. The antihyperglycemic activity of the synthesized compounds was determined using Oral Glucose Tolerance Test (OGTT), carried out on streptozotocin induced diabetic rat model. The test compounds showed significant antihyperglycemic activity when compared with standard drug, rosiglitazone....
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