Current Issue : April-June Volume : 2012 Issue Number : 2 Articles : 6 Articles
Emulgels are emulsion system, either of the oil-in-water or water in-oil type, which are gelled by mixing with a gelling agent. Both oil-in-water and water-in-oil emulsions are extensively used for their therapeutic properties and as vehicles to deliver various drugs to the skin. Emulsions possess a certain degree of elegance and are easily washed off whenever desired. In addition, the formulator can control the viscosity, appearance, and degree of greasiness of cosmetic or dermatological emulsions. Gels for dermatological use have several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removable, emollient, non staining, compatible with several excipients, and water-soluble or miscible. Gellifying the emulsion increases the viscosity of the emulsion and also its stability. The emulsion-based gel have great potential for topical drug delivery....
The purpose of the present study was to prepare solid dispersion of Tizanidine HCl using different carriers such as PEG 4000 and PEG 6000 in different ratios from (1:1 to 1:5) by fusion method. The Phase solubility profile for PEG 4000 and PEG 6000 was found to be A type solubility curve, showing drug solubility increased with increasing concentration of carriers. The FTIR spectroscopic studies showed that there is absence of well-defined drug carrier interaction and X ray diffraction study (XRD) confirmed that the overall crystalline peak of dispersions was reduced as compared to pure drug. Gibbs free energy (ΔGtr°) values were all negative, indicative the spontaneous nature of drug’s solubilization and they decreases with increasing carrier’s concentration. Dissolution studies using the USP type II apparatus using Paddle method were performed in phosphate buffer pH 6.8 for all solid dispersions and physical mixtures. The dissolution rate increases with increasing the ratio of PEG 6000 (99.98±0.45 % drug release SF15 at 60 mins) as compare to PEG 4000 (94.68±0.79 % drug release SF7 at 60 mins). All solid dispersions & physical mixture showed increased dissolution rate as compared to pure Tizanidine HCl (TZDH) drug. Also, the highest 94.3±0.61 % drug release noted at 30 mins for PEG 6000 (SF15). Finally it was concluded that PEG-6000 shows greater dissolution enhancing capacity than PEG 4000....
The aim of this study was to prepare bilayer tablet of Metoprolol Tartrate (MTP) for the effective treatment of hypertension. MTP were formulated as immediate and sustained release layer. MTP was formulated as immediate release layer by using various super disintegrants like sodium starch glycolate (SSG), cross carmellose sodium(Ac-Di-Sol) and kyron T 314. They are compared for their disintegrant efficiency. MTP was formulated as sustained release layer using hydrophilic matrix (hydroxypropylmethylcellulose [HPMC K15 M]) and Polyoxy ethylene (PEO) WSR 303. The effect of combination of hydrophilic matrix (HPMC K15M) nad Polyoxy ethylene (PEO) WSR 303 on MTP release was studied. More than 90% of Diltiazem drug was released within 1 hour. HPMC K15M and PEO WSR 303 sustained the release of Diltiazem hydrochloride from the sustained release layer for 12 hrs. Diffusion exponents (n) were determined for optimized formulation (<0.5).So, predominant drug release mechanism is Fickian diffusion mechanism. The stability study showed no significant change in appearance of tablets, drug content and dissolution profile. Therefore, biphasic drug release pattern was successfully achieved through the formulation of bilayer sustained release tablets....
The mucilage of the Plantago ovata is been used from the ancient period in the curing and treatment of the various diseases and ailments. It has been used in the ayurveda for strengthing of the body, treatment of fever, in diarrhea dysentery etc. The mucilaginous extract of the P.ovata seeds is also been widely used in various pharmaceutical and cosmetic products. The extract is used for its binder property, thickening agent, and as a sustained release agent. It is also been used in the Novel Drug Delivery System for retarding and controlling the release of the drug. Thus, the isapgol has a wide applications and be used in conventional as well as novel dosage forms for delivering the drug....
Solid dispersion is widely used for improving solubility, dissolution rate hence it ultimately helpful in increasing bioavailability of lipophilic drugs. This review article includes methods for preparation of solid dispersion and evaluation. This article covers the drug and carriers used in solid dispersion. Based on the molecular arrangement various types of the solid dispersion are enlisted here. This review article explains various application of the solid dispersion in pharmaceuticals....
The growing importance of Mouth disintegrating tablet was underlined recently when European Pharmacopoeia adopted the terms “Orodispersible Tablet” as a tablet that to be placed in the mouth where it disperses rapidly before swallowing. Their characteristic advantages such as administration without water anywhere, anytime lead to their suitability to geriatric and pediatric patients. In case of Orodispersible tablet however, main problem is bitter taste of the drug due to dispersion of active component in the saliva. Hence, it is necessary to mask the bitter taste of drug before formulation of orodispersible tablets. The aim of this study was to prepare Orodispersible tablet of taste-masked granules of Ondansetron HCl, which is bitter in taste. The taste-masked granules were prepared using Eudragit E100 by dispersion coating. The loading process was further optimized for the drug Eudragit E100 ratio. The taste-masked complex was evaluated for taste, in vitro release study. Orodispersible tablets of taste-masked complex were prepared using various superdisintegrants in different concentrations by direct compression method. All the formulations were evaluated for the influence of disintegrants and their concentration on the disintegration time of Orodispersible tablet. Tablet containing Indion 414 (Weak Cation Exchange Resin) showed better disintegrating character with rapid release at low concentration (More than 90% of drug released in 15 min.) Hence Eudragit E100 shows good taste masking effect....
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