Current Issue : October-December Volume : 2011 Issue Number : 4 Articles : 5 Articles
Oxadiazole a five membered heterocycles has been found with enormous biological activities with the suitable modifications in the structure. The present review is an attempt made to direct the attention of the researchers towards the oxadiazole ring for the development of newer chemical entities. Which are quite useful in the treatment of various life threatening diseases and disorders? Along with the development in the various methods used for the environmentally benign synthesis of oxadiazoles with profound biological activities....
Benzothiazoles and N-Substituted-a-chloro acetanilides have emerged as structurally novel anti oxidant activity. Therefore various 2-hydrazino benzothiazoles (substituted)-2-amino-(4-substituted)-acetanilides, were synthesized by an aromatic amines treated with chloro acetyl chloride in presence of glacial acetic acid and sodium acetate which gives chloro acetanilides (part-I). The condensation of various substituted chloro acetanilides with 2-hydrazino benzothiazoles, 2-hydrazino benzothiazine and 2-acid hydrazide benzothiazole reacts in the presence of dry 1.4-dioxane and triethyl amine (part-II). The structures of the synthesized compounds (A1-6), (B1-6), (C1-6) were characterized by FTIR, 1HNMR and elemental analysis. All the synthesized compounds were screened for anticonvulsant activity by 4-amino pyridine chemical induction method and phenytoin as standard drug. 4-chloro,4-bromo and 4-methoxy substituted acetanilides showed significant protection against chemical induced convulsions....
Organic compounds in which the bromine is covalently bonded to carbon, nitrogen and oxygen, are a very important group of organic halogen compounds. Even naturally occurring bromine containing organic compounds produced by marine and terrestrial plants, bacteria, fungi, insects, marine animals, and some higher animals, number nearly 1500 compounds. (A) Historically, the organic bromine compound, Tyrian, or Royal Purple, (dibromoindigo) extracted from a Mediterranean Sea mollusk, was one of the first used dyes. (B) Organic bromine compounds in which the bromine atom is retained in the final molecular structure, and where its presence contributes to the properties of the desired products. E.g. flame retardants, biocides, gasoline additives, halons, bromobutyl rubber, pharmaceuticals, agrochemicals, dyes, methyl bromide, ethylene dibromide, and halons. Organic bromine compounds have traditionally played an important role as intermediates in the production of agrochemicals, pharmaceuticals and dyes, while new process developments that result in new applications in ultraviolet (uv) sunscreens, high performance polymers, and others, are forecast to increase their market share. The world consumption of bromine for intermediates is dwarfed by the corresponding consumption of chlorine. On the simple grounds of raw material halogen cost, organic chlorine intermediates have dominated in the manufacture of low value, high volume commodity products. Bromine, however, has tended to the nucleophilic substitution in the aliphatic series may be accompanied by elimination, and the yield of the target compound depends on a number of factors (structure of the initial compound, presence and nature of solvent and catalyst, etc). 1-2 thus, alkyl bromides compete more favorably with chlorine for application as an intermediate in the above mentioned, more specialized, higher value areas. The diverse applications of organic bromine intermediates in commercial manufacture provide ample illustrations of the many virtues of bromine chemistry serving to outweigh the penalty of high halogen cost. (a) Improved selectivity in the production of bromine intermediates. (b) Improved reactivity of the intermediates in bromine displacement. (c) Cleaner processes reduction of waste, and reduced environmental impact. While (a) and (b) provide obvious improvements in manufacturing economics, the rapidly increasing demand for environmentally clean chemical processes makes (c) a major, and often dominant factor, in the choice of the intermediate and process route for a new production....
In the present study, Schiff bases of P-toluidine have been synthesized by reaction with different aromatic aldehydes and the Azetidinones have been synthesized by cyclocondensation of the synthesized Schiff’s base with chloroacetyl chloride in the presence of triethylamine. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, Mass Spectroscopic and Elemental analysis. The synthesized compounds were screened for their in vitro growth inhibitory activity against different strains of bacteria and fungi viz., Staphylococcus aureus, Escherichia coli and Aspergillus niger, Candela albicans were compared with the standard such as ciprofloxacin (50 μg/ml) and miconazole (50 μg/ml) by cup plate method. Compounds Id, IIc and IId exhibits highest antibacterial activity and compound Id, IIc and IId showed better antifungal activity....
: Salicylaldehyde upon treatment with bromoacetone in presence of anhydrous potassium carbonate give 2-acetylbenzofuran.This 2-acetylbenzzofuran after bromination give bromoacetylbenzofuran. This bromoacetylbenzofuran on treatment with thiourea in ethanol gives 4 (1-benzofuran-2-yl) 1, 3-thiazole-2-amine.The corresponding compound on treatment with various aldehydes to give different derivative. The characterization of synthesized compounds was identified o the basis of IR, NMR, MASS and elementary analysis. The compound has been evaluated for anti-bacterial activity. The present study is focused on the development of new potent bioactive molecule with less toxic, safer and easy available. Modern therapeutic is based on scientific observation supported by systematic assessment of activity of drug is simulated and clinical condition. The integrity of the drug molecule, optimization of pharmacological effect, uniform and consistent availability of drug from the dosage....
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