Current Issue : October-December Volume : 2011 Issue Number : 4 Articles : 2 Articles
Nifedipine is calcium channel blocker used in angina pectoris and hypertension. It is insoluble in water and its absorption is dissolution rate limited, its half-life is 2 – 6 hrs. Therefore, it is necessary to improve bioavailability and maintain its therapeutic concentration. The main objective of the study was to enhance the dissolution of nifedipine, a poorly water soluble drug by surface solid dispersion technique using different carriers and to study the effect of each carrier on the in vitro dissolution profile In present work the solid dispersions and physical mixture of Nifedipine were prepared with polyvinily pyrrolidone in different ratios 1:1, 1:3, 1:5, 1:7 and 1:9 to enhance its dissolution rate by using solvent evaporation technique. The obtained solid dispersions were dry, nonsticky and free flowing powder. The solid dispersions were evaluated for dissolution test, Solubility, drug content, and polymer interaction study. Among the prepared solid dispersions (1:7) has shown highest solubility and percent drug release, the X-ray diffraction and DSC also shown amorphous structure of Nifedipine....
The use of prefilled syringes is a modern way to apply parenteral drugs. With the achievements in science and technology in the past twenty years an increasing number of injectable apply prefilled syringes. The benefits compared with vial-disposable syringe concepts are obviously convenience and ease of handling as well as advantages in safety and a reduction of drug overfill. The currently existing market of prefilled syringes is in the range of US$1-2 billion. The growth rate is to be expected to remain at a high level of more than 10% annually....
Loading....