Current Issue : July-September Volume : 2022 Issue Number : 3 Articles : 2 Articles
The purpose of this investigation was to prepare and evaluate colon specific microparticles of dicyclomine hydrochloride for the treatment of bowel syndrome. Sodium alginate microspheres were prepared by ionotropic gelation method using 23 factorial designs. Ethyl cellulose coating of dicyclomine hydrochloride sodium alginate microspheres was performed by coacervation phase separation technique. The microspheres were characterized by shape, particle size, size distribution, drug content, entrapment efficiency, in-vitro drug release studies and stability studies. 2x3 factorial designs were applied by using QI MACROS 2022 to study effect and interaction on the response of %EE and %CDR and for the optimization process were performed by using DESIGN EXPERT-13 software. The outer surfaces of the core and coated microspheres, which were spherical in shape, were rough and smooth, respectively. FTIR study confirmed the compatibility of drug and polymer in physical mixture and coated formulation. The size of the core microspheres ranged from 274-705 μm and the size of the coated microspheres ranged from 624-960μm. The core microspheres sustained the release 80% of drug release at about 12 hrs at pH 7.4 dissolution medium. The release studies of coated microspheres were performed in a pH progression medium mimicking the condition of GIT. The results revealed the absence of drug release for the 2 hrs in pH 1.2 followed by 2-4 hrs (2 hrs) and 4-6 hrs (2hrs) in pH 5.5 and 6.8 respectively, however, the drug was released quickly after 6 hrs at pH 7.4 and their release was sustained over a period of 6 – 20 hrs (14 hrs). The thickness of coating influences the release pattern due to more time to dissolve at pH 7.4 It is concluded from the present investigation that Ethyl cellulose-coated sodium alginate microspheres are promising controlled release carriers for colon targeted delivery of dicyclomine hydrochloride....
Acne is a type of skin infection. It usually happens during puberty, when the sebaceous (oil) glands begin to function. Androgens are produced by the male and female adrenal glands and stimulate the glands. Acne vulgaris is a type of acne that means "common acne." It is a skin infection caused by sebaceous gland changes. The red colour is caused by skin inflammation caused by infection in the skin. Acne is a general skin condition that is associated with pimples and is common among teenagers. An anti-acne gel of niacinamide containing silver nanoparticle was prepared using carbopol as a polymer and water as a solvent and then incorporated into a topical gel using a magnetic stirrer. The product was checked for its physicochemical properties. The prepared gel’s pH, spread ability, drug content, viscosity, drug release and antibacterial activity were statistically optimized and evaluated. The antibacterial and anti-acne activities of the various formulations were checked and compared with commercially available formulations using a modified agar well diffusion method for Staphylococcus aureus cultures. Prepared topical gel of niacinamide shown the pH range 5 to 6, viscosity 434±36.56 to 651±41.43 cp, spread ability range 15.29 to 24. 51g.cm/sec, zone of inhibition ranges 12.23 to 21.65 mm, drug content ranges 91.26±0.74 to 98.74±0.63%, the drug release of gel formulation was after 12 hour was 80.74 to 71.52. The preparation of silver nanoparticles and incorporation into the niacinamide-containing gel was done successfully. Various evaluations, i.e., the physiochemical analysis, spread ability, viscosity, drug content, drug release and antibacterial study were done. This study demonstrates that the gel has a good texture, easily spreadable, has high bioavailability and effective in treating acne...
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