Current Issue : July-September Volume : 2024 Issue Number : 3 Articles : 3 Articles
Paracetamol and chlorzoxazone are well-known for their ability to treat rheumatoid arthritis and other joint pain problems. However, there is an issue with these medications' body absorption and bioavailability. This work focuses on the preparation and analysis of crystal co-agglomerates made with different polymer concentrations, such as PVA and HPMC K4M. The study's objective was to improve the drug's flow, wettability and dissolving properties as well as increase its body absorption for a more effective therapeutic effect. After the created co-agglomerates were assessed for various criteria, it was discovered that the F4 bath had the best flow ability, the highest drug content and the best dissolving properties. The created co-agglomerates were stable for the duration of the investigation without any appreciable changes to the preparation, according to the stability study and the SEM analysis, which both reveal the formation of distinct cylindrical crystals. It was determined that the process of creating crystal co-agglomerates was effective in enhancing the medication's stability and therapeutic response, as well as lowering the likelihood of the substance being metabolized....
The major goal of this research was to design and test floating tablets employing sodium bicarbonate and HPMC, aimed at increasing stomach residence duration for enhanced medication bioavailability and physicochemical compliances. The manufactured tablets passed compliance norms for several physicochemical parameters, including dimensions, floating time, tablet density and drug content. The method of Formulations for batches F2, F5 and F6 showed favourable drug release profiles, with the F7 formulation demonstrating exceptional release characteristics. The drug release kinetics studies revealed that the F2, F5, F6 and F7 formulations followed the Korsmeyer-Peppas model, indicating non-fickian diffusion with 'n' values ranging from 0.521 to 0.633. The stability studies revealed that the formulations F2, F5, F6 and F7 demonstrated stability at room temperature, 40°C and 2-8°C for 30 days, with refrigerated storage maintaining stability for 60 days. In conclusion, the produced hydrodynamically balanced Moxifloxacin HCl tablets have promising physicochemical properties, dissolving profiles and stability. These tablets have the potential to increase medication bioavailability, making them a viable choice for targeted drug delivery in the upper gastrointestinal tract....
The primary goal of this study was to improve the solubility rate of atazanavir sulphate, which in turn would increase dissolution, or the rate of drug release, resulting in increased drug absorption. The approach used here was effervescent-assisted fusion. Various batches were made using a water soluble carrier and sodium bicarbonate. The study's findings demonstrated that the medication's solubility in several solvents, including phosphate buffer and distilled water, may be improved by up to tenfold when compared to pure drug. The compatibility investigation revealed no contact between the medicine and the excipient, while the micromeretics property demonstrated good flow and compressibility properties. The produced dispersions had a percent yield ranging from 79.20±0.28% to 89.38±0.25%, with a higher rate of drug release than pure drugs (10.87%-99.14%). The pure drug had a drug release of less than 70%, but the optimized batch F5 had a drug release of more than 95% within the specified time frame. The XRD data demonstrated that the drug's crystalline structure was not impeded throughout the preparation, but the SEM data disclosed the surface shape of the pure drug, which was tile-shaped and the created dispersion, which was flakes-like in formation. The study concluded that the procedures used in this investigation were effective in increasing the drug's solubility by up to tenfold....
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