Current Issue : January - March Volume : 2013 Issue Number : 1 Articles : 6 Articles
Pellets have been used in pharmaceutical industry for more than four decades with beginning of controlled release technology that full impact of inherent advantages of pellets over single dosage form has been realized. Now day’s pelletization technology represents an efficient pathway for manufacture of drug delivery system. There is different pelletization and granulation techniques available to prepare drug loaded spherical particles or granules. Extrusion Spheronization is one of pelletization techniques and utilized in formulation of beads and pellets. Limitations related to bioavailability and site specific drug delivery can be overcome by this technique. Today this technology has gained attention because of its simple and fast processing. Compared to single-unit dosage forms, oral multiparticulate drug-delivery systems (e.g. pellets) offer biopharmaceutical advantages in terms of a more even and predictable distribution and transportation in the gastro-intestinal tract. Extrusion Spheronization is widely utilized in formulation of sustained release controlled release delivery system or modified release delivery systems. Present reviews outline manufacturing and evaluation of pellets. Manufacturing techniques includes extrusion-Spheronization have been discussed. Characterization of pellets is discussed with reference to the particle size distribution, surface area, porosity, density, hardness, friability and tensile strength of pellets....
This paper acknowledges the importance of encouraged use of latest risk management tool, HACCP in Pharmaceutical industries as an area of concern for the production of risk free pharmaceuticals that cure diseases, alleviate symptoms and improve the quality of human life; as the health of our citizens depends on the availability of effective and top quality medicines. The basic tenant of a modern quality system is that quality cannot be tested into products; it should be built-in by design. [1] An emphasis on building quality into products allows an improved focus on analysis of the barriers to HACCP implementation which include availability of appropriate training of personnel to apply the HACCP methodology, access to technical expertise, scientific knowledge of essential manufacturing processes and the general problems of time and human resources. The paper concludes with a summary of the benefits or barriers that Pharmaceutical sector faces as it aims of providing a high-quality drug product to patients and has the health and safety of patients in mind....
Increasing number of poorly water soluble drugs has gained recognition in recent drug development. These drugs lack the ability to go into solution and it is sometimes a more important limitation for its overall rate of absorption than its ability to permeate the intestinal mucosa. Hence it would be extremely useful to have a predictive in vitro dissolution test which correlates with in vivo absorption. Such kind of test could be used when screening new formulations as well as changes in existing formulations with regard to their impact on bioavailability, Pharmaceutical industries and scientists face some challenges to develop such meaningful in vitro dissolution. The present study is an overview on the approaches like simulation of the in vivo gastrointestinal physiology with in vitro dissolution testing methods. These approaches include media composition using bile salts and lipoproteins, changing physicochemical properties which influence drug dissolution, effect of preprandial and postprandial state. Out of the aforementioned strategies use of biorelevant media is the most preferred one. There are many ways to develop the biorelevant media like varying the composition of bile salts and lecithin. Apart from these, surfactant media and novel pH adjusted biphasic media have been discussed. It was found that optimization of biorelevant media is necessary to achieve perfect correlation, but it is unstable and costly. Hence surfactant media and novel pH adjusted biphasic media are better to use out of which biphasic media is cost effective and reduces the money and wastage of time for industries....
This review represents development and innovation in parenteral technology for delivering the drug in an effective and efficient way. In conventional parenteral administration, there are so many disadvantages like pain at the site of injection, chances of spreading of diseases, short duration of action. Now a day, there are so many advance technology to overcome the drawbacks of conventional parenteral administration. The technologies like Medusa, SABER drug delivery system, Medisorb Microsphere, Bioject’s needle free injection, Pain free blunt needle. After one administration, these systems can maintain the drug in the desired therapeutic range for days, weeks, months, and for some products, even years....
A comprehensive review is given on what packaging material means, the material used for packaging of pharmaceutical product in different aspects of storage purpose and the impact of this packaging on stability of product. There is a need of stability data for the shelf life determination of the product. Container closure system becomes more important in pharmaceutical packaging. Stress testing is also very much important tool now a day. Stability data is providing confidence on the shelf life and storage condition of finished product....
The Purpose of this article is that to provide the knowledge about what istechnology transferred, when and why information should be transferred to where and by whom and how to transfer, which factor affect the technology transfer and how to over come it....
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