Current Issue : October - December Volume : 2013 Issue Number : 4 Articles : 8 Articles
Lagenaria siceraria is a wonderful fruit vegetable consisting of various important phytochemicals. Traditionally, it had been used as a body tonic, hypolipidemic, cardioprotective, diuretic, analgesic, purgative and anthelmintic agent. The fruits and leaves had been used to treat bronchial disorders such as pectoral cough, asthma, jaundice, baldness, headache and anaemia. In this study, pharmacological and toxicological screening of Lagenaria siceraria has been carried out to study its effects on the hematological and biochemical parameters. This study would help to determine the effects and limitations of this herb to be used as a medicine. Aqueous extract of leaves of Lagenaria siceraria (AELS) at the dose of 200 and 400 mg/kg p.o. was given to New Zealand white rabbits. After thirty days of dosing, the effect of the extract on hematological and liver profile was assessed. Results showed that haemoglobin (Hb), RBC count and hematocrit of Lagenaria siceraria treated rabbits were increased highly significantly (bp<0.001) when compared to normal control rabbits. WBC and platelet counts were decreased. There was a non-significant increase in MCH and MCHC and a non-significant decrease in MCV of AELS 200 and 400 mg/kg groups. The results show that AELS has significant hematopoietic and haematinic potential and can safely be used to treat anaemia....
Several investigations have confirmed the efficacy of many of these traditional preparations, some of which have proven efficacy. In the present study antiarthritic activity of ethanolic extract of roots of Smilax perfoliata on complete freunds adjuvant method was investigated. Smilax perfoliata L. (Smilaceae) has been used in Indian traditional medicines against various ailments. Arthritis was induced by injecting 0.05 ml of suspension of killed mycobacterium tuberculosis bacteria (0.5% w/w) homogenized in liquid paraffin into the left hind paw, these complete freunds adjuvant method rats were divided into five groups: first group received 1% CMC to serve as arthritic control, second group received complete freund’s adjuvant 0.1ml to serve as negative control group, third group received Indomethacin 10mg kg-1 b.wt (p.o) for 12 days, fourth group received ethanolic extract of Smilax perfoliata (EESP) 200mg kg-1 b.wt (p.o) for 12 days, fifth group received ethanolic extract of Smilax perfoliata (EESP) 400mg kg-1 b.wt (p.o) for 12 days. The histological studies, haemotological, biochemical parameters and measured paw volume are used to assess the effectiveness of the treatment. Increasing dosage of Smilax perfoliata ethanolic extract produced a dose dependent significant reduction in the arthritic activity. It is concluded based on these findings that S.perfoliata may be effective in treating arthritic activity....
Smilax perfoliata is used in treatment of abscesses, skin disorder, sores, swellings, venereal disease and to evaluate antiepileptic activity. The Present investigation has been under taken to evaluate the antiepileptic and antioxidant activity of ethanolic extract of roots of Smilax perfoliata in experimental animals. Induction will be done with electric shock (150mA for 0.2sec) in rats. The experimental study period of 45 days was continuously studied to evaluate the normal behavior parameters such as locomotor activity, motor coordination test, memory of rats and also antioxidant parameters (SOD, GSH, CAT, LP) will be estimated after study period. Hence the further pharmacological activity (Antiepileptic activity) was performed to support the traditional use....
The anti-inflammatory effect of various fractions (50 mg/kg) of Nyctanthes arbor-tristis leaves was investigated in carrageenan induced rat paw edema model. Both butanolic and chloroform fraction highly and moderately significantly (P<0.01) inhibited carrageenan induced paw edema model. Phytochemical analysis of butanolic fraction showed presence of tannins, flavonoids and iridoid glycosides and chloroform fraction showed presence of flavonoids and terpanods. The butanolic fraction was found to be more effective than chloroform, pet ether and aqueous fraction. Thus the ant-inflammatory potential of Nyctanthes arbor-tristis leaves may be due to presence of active constituents like flavonoids and iridoid glycosides Present in butanolic fraction and terpenoids in chloroform fraction....
Androgenic alopecia, also known as male pattern baldness is hair loss that occurs due to an underlying susceptibility of hair follicles to androgenic miniaturization. Research studies revealed that environmental factors, hormonal imbalance and/or hereditary factors causes alopecia but many etiologies remain unknown. Treatment approach for androgenic alopecia are based on hair growth enhancement and reducing the progression of hair thinning. Other than allopathic medicines few herbal drugs over the decades has proved effective and fruitful results in combating alopecia. In the present study Seeds of Terminalia bellirica and rhizomes of Nardostachys jatamansi are evaluated for hair growth activity in androgen induced alopecia rat model. Petroleum ether extract of both plant at the dose of 2% and 5% was applied topically for evaluating their potential against alopecia. Alopecia was induced in albino rats by intramuscularly administration of testosterone for 20 days. Plant extract were simultaneously applied to inhibit the effect of androgen to develop alopecia. Finasteride was served as positive control. At the end of experiment growth of hair by visual inspection, follicular density by ocular micrometer and anagen/ telogen ratio by animal skin biopsy was investigated. Observed results revealed that both plant at 5% dose exhibited remarkable potential against androgen as evident by promising hair growth-promoting activity, follicular density and A/T ratio. Further studies are needed to isolate the biological active constituents and investigate the possible mechanism of action...
Hepatology research has focused on developing traditional therapies as pharmacological medicines to treat liver diseases and cirrhosis. Thus The present study was designed to evaluate the hepatoprotective activity of ethanolic extract of Pancratium Longiflorum leaves and flowering stem against thioacetamide (400mg, SC) induced hepatic damage in albino rats was observed. The ethanolic extract at dose of (300mg and 600mg/kg, p.o) Offered significant (p<0.001) hepatoprotective action by reducing the serum marker enzymes like SGPT, SGOT, ALP. They also reduced the elevated level of total bilirubin and reduction in pentobarbitone induced sleeping time, preventing induced reduction in ascorbic acid excretion in rat urine, increased bromsulphalein (BSP) uptake and histopathological studies further confirm the hepatoprotective activity of Pancratium Longiflorum. When compared to the thioacedamide treated control groups the results obtained were compared with Silymarin (100mg, p.o.) the standard drug....
The anticancer-cytotoxic activities of ethanolic extract of Pleiospermium alatum were tested under invitro conditions in different cancer cell lines like MCF-7, MDAMB-231,Hela, HepG2 cell lines. The active constituents carbohydrates, steroids, Alkaloids, Tannins, Flavanoids, Saponins, gums and mucilage. The ethanolic extract of Pleiospermium alatum sowed a good cytotoxic activity ( 60%,60%,85% and 65%) in Hela , HepG2, MCF-7, MDAMB-231 cells at 24 hrs respectively. In this invitro studies the normal cells are act as a positive control. The ethanolic extract of Pleiospermium alatum shows maximum percentage of 85% after 24 hrs. From this study, it can be concluded that the phytoconstituents of Pleiospermium alatum have significant anti cancer-cytotoxic activity on Hela , HepG2, MCF-7, MDAMB-231 cells....
Oxidative stress and mitochondrial dysfunction are major events leading to nerve cell death. Oxidative stress and related mitochondrial dysfunction is one of the common cooperative sharing pathways involved in neurodegenerative disorders including Huntington's disease. Flavonoids have well known antioxidant activity. Biochanin A is an isoflavone isolated from red clover (gen name Trifolium pretense) resemble the structure of oestrogen, and display agonistic interactions with the oestrogen receptor. Oestrogen and Biocanin A is reported to be a neuroprotective antioxidant. Systemic 3-nitropropionic acid (10 mg/kg/i.p) treatment for 14 days in rats significantly induced huntington’s disease like symptoms in rats as indicated by reduced locomotor activity, body weight, grip strength, cognition, oxidative defense and mitochondrial enzymes (complex-I, -II and lactate dehydrogenase) activities in striatum. The effect of biochanin A on 3 nitropropionic acid oxidative stress and mitochondrial enzyme activities was investigated. Treatment with biocanin A (5, 10 and 15 mg/kg/oral) significantly reversed behavioral, biochemical enzyme dysfunctions in 3-nitropropionic acid treated group....
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