Topical delivery is an attractive route for the local and systemic treatment. The delivery of the drugs onto the skin is recognized as an effective means of therapy for local dermatologic diseases. Topical gels are becoming more popular due to ease of application and better precutaneous absorption. Topical gel drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routs. Gel formulation provides better application property and stability in comparison to cream and ointment. Topical application of drugs offers potential advantages of delivering the drug directly to site of action and acting for an extended period of time. The purpose of the present work was to develop topical drug delivery system of ketoconazole. The gel formulation was designed by using Ocimum basilicum mucilage, Carbopol 940 and HPMC K100M as gelling agents. The physicochemical parameters of all formulations were determined. In-vitro drug release study of F2 formulation shows the 94.16% drug release and permeation studies done with cadaver skin of F2 formulation shows 89.57% drug release in 6 hrs respectively. The stability study revealed no significant difference between before and after storage....
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