Current Issue : July - September
Volume : 2021
Issue Number : 3
Articles : 5 Articles
Combining amoxicillin with the immunostimulatory toll-like receptor 4 agonist monophosphoryl
lipid A (MPLA) represents an innovative approach for enhancing antibacterial treatment
success. Exploiting pharmacokinetic and pharmacodynamic data from an infection model of
Streptococcus pneumoniae infected mice, we aimed to evaluate the preclinical exposure-response relationship
of amoxicillin with MPLA coadministration and establish a link to survival.....................
While the antiarrhythmic drug amiodarone is commonly used in clinical practice, it has a
narrow therapeutic index that can lead to acute overdose. One proposed method to deal with this
toxicity is lipid emulsion therapy, which may potentially quench the free amiodarone in blood and
prevent its further distribution to target organs and tissues. In this study, we utilize an established
swine model to examine the effects of Intralipid™ (IL) administration for acute amiodarone toxicity....
A sequential pharmacokinetic (PK) and pharmacodynamic (PD) model was built with
Nonlinear Mixed Effects Modelling based on data from a first-in-human trial of a novel biologic,
MEDI7836. MEDI7836 is a human immunoglobulin G1 lambda (IgG1λ-YTE) monoclonal antibody,
with an Fc modification to reduce metabolic clearance. MEDI7836 specifically binds to, and functionally
neutralizes interleukin-13. Thirty-two healthy male adults were enrolled into a dose-escalation
clinical trial. Four active doses were tested (30, 105, 300, and 600 mg) with 6 volunteers enrolled
The Quantitative Structure-Activity Relationship (QSAR) methodology was used to predict
biological properties, i.e., the blood–brain distribution (log BB), fraction unbounded in the brain
(f u,brain), water-skin permeation (log Kp), binding to human plasma proteins (log Ka,HSA), and intestinal
permeability (Caco-2), for three classes of fused azaisocytosine-containing congeners that
were considered and tested as promising drug candidates.................
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