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Inventi Impact - Pharm Tech

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    Journal Scope:

    Quarterly published in print and online ‘Inventi Rapid/Impact: Pharm Tech’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutics and pharmaceutical technology. It welcomes articles pertaining to physical, chemical and biological properties of dosage forms, devices and delivery systems for drugs, vaccines and biologicals including their design, manufacture and evaluation. Special emphasis is given for articles pertaining to excipients such as surfactants and polymers and novel materials, and products for personalized medication.

  • FORMULATION AND EVALUATION OF BUCCAL FILMS OF ONDANSETRON HYDROCHLORIDE
    Neha Sorayan*, Urmi Chaurasia    Download Full Text

    The present study involves the formulation and evaluation of buccal films of ondansetron HCl using HPMC K15M, eudragit RL-100 and chitosan in various proportions and combination. The films were fabricated by solvent casting method using ondansetron hydrochloride, an antiemetic drug has oral bioavailability of 60% due to hepatic first metabolism and a short half-life of 5 hrs. Buccal route is an ex...

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  • DEVELOPMENT AND EVALUATION OF COLON TARGETED MICROENCAPSULATED MICROSPHERES OF CAPECITABINE
    Tanaji D Nandgude*, R Sundara Ganapathy    Download Full Text

    The objective of present work was to develop microencapsulated chitosan microspheres for colon specific drug delivery of capecitabine. As reported initially, in-vitro drug release studies showed more drug release through chitosan microspheres demanded microencapsulation. The system consists of developed chitosan microsphere entrapped within eudragit FS30D polymer which combines pH dependent solubi...

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  • SOLUBILITY ENHANCEMENT OF ANTI TB DRUG RIFAMPICIN BY SOLID DISPERSION TECHNIQUE
    Sakshi Ranawat, Kalpana Patidar*, Manish Soni    Download Full Text

    This research work was an attempt to increase the solubility dissolution rate of rifampicin by solid dispersion as the poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T. fluid often leads to insufficient bioavailability, this low bioavailability leads to less therapeutic effect of particular drug. Rifampicin belongs to BCS class II, which is slightly solub...

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  • FORMULATION AND EVALUATION OF GLIMIPRIDE FAST DISSOLVING TABLETS
    T Balakrishna*, J Ramesh Babu, S Vidyadhara, T E G K Murthy    Download Full Text

    The aim of the present study was to formulate, evaluate and optimize fast dissolving tablets of glimepiride. Glimepiride is one of the third generation sulfonylurea used for treatment of type 2 diabetes. Poor aqueous solubility and slow dissolution rate of the glimepiride lead to irreproducible clinical response or therapeutic failure in some cases due to sub therapeutic plasma drug levels. Conseq...

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  • BIOAVAILABILITY ENHANCEMENT OF BCS CLASS 4 DRUG BY SELF EMULSIFIED DRUG DELIVERY SYSTEM
    Swapnil V Pande*, Kailash R Biyani    Download Full Text

    The self emulsified drug delivery system (SEDDS) is characteristic property of water-in-oil emulsion formulation which gets emulsified by little motility in GIT. The mixture of surfactant and co-surfactant forms stable emulsion which have minimal free energy as it forms with minimal energy of emulsification. The excipients were selected with drug solubility and the flow ability of emulsion...

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  • STUDIES ON FORMULATION AND EVALUATION OF AMOXICILLIN TRIHYDRATE RECONSTITUTABLE SUSPENSION
    J Ramesh Babu*, B Sowjanya Lakshmi, S Vidyadhara    Download Full Text

    Amoxicillin trihydrate (a-amino-hydroxybenzyl-penicillin) is a semi synthetic, orally absorbed, broad-spectrum antibiotic. It is a drug of choice in the treatment of infections including chest (bronchitis/pneumonia), ears (otitis media), gonorrhea and urinary tract infections. The present work was carried out to formulate, optimize and evaluate a reconstitutable suspension of amoxicillin trihydrat...

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