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Inventi Impact - Pharm Tech

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    Journal Scope:

    Quarterly published in print and online ‘Inventi Rapid/Impact: Pharm Tech’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutics and pharmaceutical technology. It welcomes articles pertaining to physical, chemical and biological properties of dosage forms, devices and delivery systems for drugs, vaccines and biologicals including their design, manufacture and evaluation. Special emphasis is given for articles pertaining to excipients such as surfactants and polymers and novel materials, and products for personalized medication.

  • DESIGN AND DEVELOPMENT OF PALIPERIDONE LIQUISOLID COMPACTS TO ENHANCE SOLUBILITY
    K Arshad Ahmed Khan*, A Aswini, B Srinath, C Suryaprakash Reddy    Download Full Text

    Paliperidone is a second generation antipsychotic agent, used in the treatment of schizophrenia. It is a hydrophobic drug which belongs to BCS class II and it has low bioavailability of about 28%. The present study was designed to improve the in-vitro dissolution properties of poorly soluble antipsychotic drug paliperidone by adopting the liquisolid technology. Liquisolids were prepared by powder ...

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  • FORMULATION AND EVALUATION OF MONTELUKAST SODIUM FAST DISSOLVING TABLETS
    Shiva Kumar Yellanki*, Teelavath Mangilal, M Sushanth    Download Full Text

    The demand for fast dissolving tablet (FDT) has been growing during the last decade especially for elderly people and children who have swallowing difficulties. Montelukast is a leukotriene receptor antagonist (LTRA), anti-asthmatic used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is effective in relieving nasal congestion, particularly in patients wit...

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  • PLEASANT TASTING GRANULES OF CLARITHROMYCIN
    Yitesh Jagwani*, Siddhraj S Sisodia    Download Full Text

    Clarithromycin has poor acceptance by pediatric and geriatric patients due to very bitter taste. Usually, in dry syrup formulations, high concentration of sugar is used for taste masking purpose. But high consumption of sugar has been related to several chronic diseases and several times is unable to mask the extreme bitter taste. Therefore this study aimed to investigate taste masking capacity of...

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  • EFFECT OF PH ON THE EFFICACY OF THE SODIUM BENZOATE AS ANTIMICROBIAL PRESERVATIVE IN TOPICAL FORMULATION
    Shelke Om*, Kulkarni Amol    Download Full Text

    Preservatives are used to maintain the microbiological attributes of the formulation throughout the shelf life. Sodium benzoate is used as preservative in oral, parenteral and topical formulations. Antimicrobial effectiveness testing (AET) was carried out using different concentration of sodium benzoate at different pH levels. Bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureu...

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  • DEVELOPMENT AND EVALUATION OF FLOATING TABLETS OF TRIMEBUTINE MALEATE USING HYDROPHILIC POLYMERS
    Mahmoud Mohamed Ghorab, Salwa Salah, Ibrahim Salah Mousa*    Download Full Text

    Various approaches have been used to retain the dosage form in the stomach as a way of increasing the gastric residence time, including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extendible or swellable systems and superporous hydrogel systems. Trimebutine maleate has a short elimination half-life and is mainly absorbed in proximal areas of GIT. T...

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  • FORMULATION APPROACHES TO ENHANCE THE SOLUBILITY OF POORLY SOLUBLE DRUGS
    Ahmed Abd El-Bary, Ibrahim Al Sharabi*    Download Full Text

    Sufficient aqueous solubility is an important criterion for a drug candidate for further development. Poor aqueous solubility is usually associated with erratic and low bioavailability. Enhancing aqueous solubility is an essential task during the development process of such compounds. Different formulation approaches have been utilized to overcome this obstacle. Solid dispersions, cyclodextrin com...

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