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Quarterly published in print and online "Inventi Impact: Pharm Tech" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutics and pharmaceutical technology. It welcomes articles pertaining to physical, chemical and biological properties of dosage forms, devices and delivery systems for drugs, vaccines and biologicals including their design, manufacture and evaluation. Special emphasis is given for articles pertaining to excipients such as surfactants and polymers and novel materials, and products for personalized medication.
The aim of the study was to prepare indomethacin nanocrystal-loaded, 3D-printed, fastdissolving
oral polymeric film formulations. Nanocrystals were produced by the wet pearl milling
technique, and 3D printing was performed by the semi-solid extrusion method. Hydroxypropyl
methyl cellulose (HPMC) was the film-forming polymer, and glycerol the plasticizer. In-depth
physicochemical characterization was made, including solid-state determination, particle size and
size deviation analysis, film appearance evaluation, determination of weight variation, thickness,
folding endurance, drug content uniformity, and disintegration time, and drug release testing. In drug
nanocrystal studies, three different stabilizers were tested. Poloxamer F68 produced the smallest and
most homogeneous particles, with particle size values of 230 nm and PI values below 0.20, and was
selected as a stabilizer for the drug-loaded film studies. In printing studies, the polymer concentration
was first optimized with drug-free formulations. The best mechanical film properties were achieved
for the films with HPMC concentrations of 2.85% (w/w) and 3.5% (w/w), and these two HPMC levels
were selected for further drug-loaded film studies. Besides, in the drug-loaded film printing studies,
three different drug levels were tested. With the optimum concentration, films were flexible and
homogeneous, disintegrated in 1 to 2.5 min, and released the drug in 2–3 min. Drug nanocrystals
remained in the nano size range in the polymer films, particle sizes being in all film formulations
from 300 to 500 nm. When the 3D-printed polymer films were compared to traditional film-casted
polymer films, the physicochemical behavior and pharmaceutical performance of the films were very
similar. As a conclusion, 3D printing of drug nanocrystals in oral polymeric film formulations is a
very promising option for the production of immediate-release improved- solubility formulations....
Nanotechnology mediated drug transport presents a promising approach for targeted drug delivery owing to its capability of better stability and sustained drug release. Compared with different drug delivery techniques, nanoparticles have distinct advantages in improving the transport of drugs across the nasal mucosa. In the present work galantamine, an acetycholinesterase inhibitor used in the treatment of Alzheimer’s selected as model drug for nasal permeation study. Galantamine loaded chitosan and thiolated chitosan nanoparticles were formulated by ionic gelation method and characterized. Ex-vivo permeation of nanoparticles across nasal epithelium was evaluated by Franz diffusion cell. The polymeric mucoadhesive nanoparticles found to have better permeation across the nasal mucosa as compared to the drug solution....
The aim of this study was to prepare amoxicillin tri-hydrate (AMXT) granules in the form of single dose (125mg) sachet for pediatric use. A 33 full factorial design to select the best disintigrant, diluent and lubricant, followed by a 23 factorial design for the selection of the optimum excipient concentration as well as the most appropriate techniques for the preparation of drug granules were performed. Finally a complexation study using Ã?Å¸CD (Ã?Å¸-cyclodextrin) or HPÃ?Å¸CD (Hydroxy propyl Ã?Å¸-cyclodextrin) was done. The best formulae obtained from the factorial design, based on the flow ability properties (Angle repose), saturated solubility study and release after 5 minutes from the prepared granules were further investigated after complexation with CD (cyclodextrins). Results showed that optimized amoxicillin tri-hydrate 125 mg sachet in the formation with the composition: 44%Avicel PH101, 1%Mg.Staerate, 5%Ac.Di.Sol and 1:3 AMXT: HPÃ?Å¸CD complexation using freeze drying showed an increased solubility and stability of amoxicillin tri-hydrate and thus can be used as a single dose sachet dosage form replacing the currently available drug suspension for pediatric use....
The vagina remains to be an unexplored route of drug delivery. As a site of drug delivery it offers certain unique features which made vagina an excellent route of drug delivery for both local and systemic effect. Gels are semi-solid systems form a three-dimensional, polymeric matrix in which a high degree of physical/chemical reticulation has been comprised. Gels can present several advantages over other vaginal drug delivery systems such as higher bioavailability, safety, versatility, and economical savings. They are mainly used for topical delivery of contraceptives, anti bacterial, antifungal, antiprotozoal, antiviral, labor-inducing and spermicidal agents, prostaglandins, steroids and also used as an “empty” gel for moisturizing of dry vaginal mucosa. vaginal gels possess a higher biocompatibility and bioadhesivity and can be rapidly eliminated through normal catabolic pathways which decreases the risk for irritative or allergic host reaction at the application site. Mucoadhesive polymer is being used to improve performance of gel and it will be retained at the site and release the drug in a controlled and prolonged manner, so that the drug can be continuously supplied to the absorption sites and reduces dosing frequency. Here, discussed and summarized use and research being done on gel as vaginal drug delivery....
Tablet is the most popular dosage form among from all existing dosage form. but in some instances due to the large size of dosage forms, and in case of uncooperative, pediatric and dysphasia patients, it may create some problems, to overcome this problems, a new form of dosage form is developed, which is known as first dissolving tablet or mouth dissolving tablet. These tablets are the advanced dosage form which is dissolve with in few seconds after placing on the tongue. Fast dissolving tablets have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. Today Melt in Mouth Tablets (MMT) are a proven & accepted technology for the systemic delivery of active pharmaceuticals ingredients....
The objective of this study was to prepare and evaluate a novel gelatinized tableting excipient using a mixture of banana starch and Starch 1500. Recently Banana starch has been studied as a direct compression adjuvants for oral tablet dosage forms. Direct compression Paracetamol tablets prepared using Partially pregelatinized banana starch and starch 1500 met the requirements of uniformity of weight, assay, friability, hardness, disintegration time (DT) and in vitro drug release. Novel Pregelatinized banana starch showed adequate binding and disintegrating characteristics. We were made D.C. Paracetamol tablet matrix containing modified banana starch-starch 1500 mixtures and studied their possible erosion-diffusion mechanism and release rate in dissolution tests which was found to be similar to that of the Starch 1500 matrix. In conclusion, the spray-dried granules prepared with Novel banana starch and Starch 1500 showed excellent flow properties and were suitable for tableting....
Alginate-based composite sponges were developed as carriers to prolong the gastric\nretention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems\n(Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution made up of a mixture of\npolymers and converted into a solid form by freeze-drying. The ratio of alginate as the main polymer,\nadsorbent (colloidal silicon dioxide), and additional polymersÃ¢â?¬â?sodium carboxymethyl cellulose\n(SCMC), hydroxypropyl methylcellulose (HPMC)Ã¢â?¬â?was varied systematically to adjust the drug\nloading and entrapment efficiency, sponge buoyancy, and the release profile of Cur-SMEDDS. The\noptimum composite sponge was fabricated from a 4% alginate and 2% HPMC mixed solution.\nIt immediately floated on simulated gastric fluid (SGF, pH 1.2) and remained buoyant over an 8 h\nperiod. The formulation exhibited an emulsion droplet size of approximately 30 nm and provided\nsustained release of Cur-SMEDDS in SGF, reaching 71% within 8 h compared with only 10% release\nfrom curcumin powder. This study demonstrates the potential of alginate-based composite sponges\ncombined with self-microemulsifying formulations for gastroretention applications involving poorly\nsoluble compounds....
Nanocrystallization and amorphization have proven to be two effective strategies to improve\nthe bioavailability ofwater-insoluble drugs. The purpose of ourworkwas to develop a nano-formulated\ntablet of sirolimus (SRL) for enhanced dissolution. Amorphous SRL nanocomposites were prepared\nusing anti-solvent precipitation via a high-gravity rotating packed bed. Various factors that affect\nparticle size and size distribution, such as excipients, rotating speed, antisolvent/solvent flow rate,\nwere investigated. Structure, stability and in vitro dissolution of the as-prepared SRL were evaluated.\nFurthermore, the nanoparticulated SRL tablet formulawas screened to control drug release. Importantly,\nSRL tablets exhibit different dissolution profile by adjusting HPMC (hydroxypropyl methyl cellulose)\ncontent, which makes them more suitable for various formulation developments....
The aim of the present investigation was to develop controlled release matrix tablet formulations of metformin hydrochloride using Chitosan and Eudragit L100 polymer alone and in combination at different concentrations and to evaluate in vitro release characteristics. Metformin HCL, a biguanide has relatively short plasma half life, low absolute bioavailability. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. Mean dissolution time is used to characterize drug release rate from a dosage form and indicates the drug release retarding efficiency of polymer. Hydrophilic matrix of Chitosan alone could not control the Metformin release effectively for 12 h whereas when combined with Eudragit L100 could slow down the release of drug and can be successfully employed for formulating sustained-release matrix tablets. Swelling studies were also carried out. Fitting the data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release....
Emerging technological knowledge is leading research into new ventures. Synthetic polymers frequently suffer from the problem of being non-biocompatible, non-biodegradable and expensive. During the past two decades significant advances have been made in the development of natural polymer alone or in combination with synthetic polymeric materials for biomedical applications. Biodegradable polymers are highlighted in their performance in terms of biocompatibility. Therefore in this review we have made an attempt to summaries a role of polymers with potential applicability in medical and pharmaceutical field. Cheap and abundant availability of natural polymers offers an opportunity for its use. Biocomposites with low toxicity can be prepared with natural (collagen) and a synthetic polymer [poly (e-caprolactone)]. In order to overcome biological deficiency and to enhance mechanical characteristics of natural polymers a combination with synthetic polymers or derivatives of natural polymers are utilized. Combination of advantageous properties of natural polymers and hydroxyapatite has been explored in bone defects. It shows application in bacteria preservation. In bio-applications, biocompatibility and/or biodegradability of triglyceride oils play an important role therefore during the 21st century number of polymers are synthesized and evaluated for possibility of utilizing such methods for various applications....
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