Abstracted/ Indexed in: CNKI Scholar (China National Knowledge Infrastructure), Ulrich's International Periodical Directory, Google Scholar, SCIRUS, getCITED
Quarterly published in print and online "Inventi Rapid: Urology & Nephrology (Formerly Inventi Rapid: Kidney)" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal welcomes papers in all the areas of nephrology practices and clinical research. It encourages submissions of latest findings related to pathogenesis and treatment of kidney diseases, hypertension, acid-base and electrolyte disorders, dialysis therapies, and kidney transplantation.
Chronic kidney disease (CKD) represents a major public health issue and requires substantial financial and health care resources. Finding novel ways in treating predialysis patients effectively and prevention of progression of the disease to end stage renal disease is the vital tool to tackle this issue. This study aims to assess role of nitrozyme (a mixture of symbiotic and proteolytic enzyme) in the renoprotective effect in gentamycin induced nephrotoxicity. Wistar albino rats (n=84) of either sex were divided into seven groups of 12 each. Group I received an i.p. injection of normal saline daily for 5 consecutive days followed by oral RO water (10 mg/kg, p.o.) for 28 days, Group II received test product proteolytic enzymes (75mg/day, p.o) in three divided doses for 28 days, Group III received test product Enzobiotic (1075mg/day, p.o) in three divided doses for 28 days, Group IV, V, VI and VII received gentamycin (120 mg/kg, i.p.) daily for 5 consecutive days followed by oral RO water, Group IV only gentamycin test product symbiotic Group V, test product proteolytic enzymes Group VI and test product enzobiotic Group VII respectively for 28 consecutive days. The efficacy parameters analyzed were body weight, serum biochemical parameters, urine, fecal analysis and histopathological features. One way ANOVA was used to compare the mean of all the groups followed by the Bonferroni Post hoc multiple comparison tests. Enzobiotics treated rats showed statistically significant decrease in blood urea nitrogen ( 23.51 ± 3.5 mg/dl), serum creatinine (0.8 ± 0.15 mg/dl) and an increase in serum protein (6.54 ± 0.41 mg dl) as compared to gentamycin control group. There was also a significant decrease in urine protein levelsin enzobiotic group compared to gentamycin control group. Renal histopathology of rats treated with enzobiotics - showed significant renoprotection and regenerative changes. There were no significant differences between other test product groups and gentamycin control group. The present study demonstrates that enzobiotic, a combination of probiotic and proteolytic enzyme supplementation had a renoprotective and curative role both biochemically and histologically against gentamycin induced nephrotoxicity in Wistar albino rats....
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