IBI Factor 3.9
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Quarterly published in print and online "Inventi Rapid: Advanced Dosaging" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on finding the newer methods of administering active pharmaceuticals to the patients either through newer dosage forms of by deploying newer administration devices. The first of its kind of journal, "Inventi Rapid: Advanced Dosaging" invites researchers sharing new insight in achieving the therapeutic goals.
In the present study, spherical microbeads are able to prolong and control the release of nifedipin. were prepared by ionotropic gelation method, using sodium alginate as the hydrophilic carrier in combination with HPMC and sodium alginate as drug release modifiers in various proportions to overcome the drug related adverse effects, improve drug bioavailability in different GI tract conditions. Formulated microbeads were investigated for physicochemical properties and drug release potential. All investigated properties showed satisfactory results. While testing size distribution, flow properties and mean diameter of microbeads, there was no significant drug-polymer interactions were observed. The formulated floating alginate beads have shown higher percentage (28.11 % to 39.98 %) of drug loading, particle size (610.75 to 845.62 , higher release of drug. The Optical microscopy of floating alginate beads reveals that the beads are mainly spherical and the use of calcium carbonate, which provides floating property. In-vitro dissolution study showed that 90 % drug release, amongst the formulations, formulation 4 released Nifedipin for prolonged duration (12 hours). Formulated floating beads of Nifedipin showed good swelling behavior....
Administration of drugs to children and elderly is not always easy when there is cases of API like antibiotics, analgesics and antidiabetics in which large amount is required to administer then it results in to dosage form which is difficult to swallow orally by paediatrics and geriatrics. Dose Sipping (DS) Technology administering tasteless granules to patients by forming in-situ suspensions in the patient’s favorite beverage requires a complex development of a drinking straw. Each straw contains a single dose of small coated granules containing the prescribed amount of API in a suitably taste masked formulation. Each drinking straw system is individually packed and only removed for oral administration in-situ, while the patient drinks beverages using the straw as they are using every day drinking straw. In this way, there is no need to redisperse the powder or granules prior to administration. While sipping the beverage passes the movable controller and suspends the granules in-situ on the way to the patient’s mouth. After swallowing the suspension complete application of the drug can be checked by looking whether the controller has reached the upper end of the tube....
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