IBI Factor 3.9
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Quarterly published in print and online "Inventi Rapid: Biomedical Analysis" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. It focuses on biomedical analytical techniques including method development, instrumentation, computation and interpretation from academic, clinical and industrial perspectives. The journal accepts papers related to analytical aspects of traditional folk medicines, drug purity and stability studies, pharmacokinetics, therapeutic monitoring, metabolic profiling, analytical biochemistry, forensic toxicology and quality assurance.
Biochemistry is the branch of science, which started its influence in medicine world, during 19th century and later. Since, then it has contributed a lot to the scientific world and in our understanding of nature of the living organisms. Coding practices have been in use in medicine, since early years nearly in mid-1950. Coding procedures help in bringing harmonization in the overall operations of the system of medicine, wherever its application has been implemented in the system, for e.g. in U.S. Biochemical coding means to initiate coding practices, in all biochemical studies and experimental practices, in order to bring harmonization to its contribution towards understanding of living organisms and understanding life more clearly both scientifically as well as chemically. Bio-chemical coding will help in reporting of all scientific procedures and discoveries in the form of codes, which will help in restricting the duplicity of the practices all across the world. Hence, biochemical coding if implemented all across the world, will help in bringing duplicate practices in front of the regulatory authorities, as well as it will help in complete harmonization of the discipline as such....
A simple and rapid liquid chromatography/tandem mass spectrometry (LC-MS/MS) method has been developed and applied for estimation of valganciclovir concentration levels in dog plasma after administration of valganciclovir extended release tablets (450 mg) and Valcyte® immediate release tablets (450 mg). Valganciclovir exposure in dogs is low hence ganciclovir was monitored instead of valganciclovir. The drug and internal standard, ISTD (Trospium HCl) were extracted from plasma by protein precipitation technique. The analytes were separated using a mobile phase of ammonium formate (10 mM) and organic mixture containing acetonitrile and methanol (20:80, v/v) on Zorbax SB C18, 75 x 2.1 mm, 3.5 µm with guard column at a flow rate of 0.3 ml/min and analyzed by a triple-quadrupole mass spectrometer in positive ion multiple reaction monitoring (MRM) mode at transitions (m/z) of 355.4152.2 for valganciclovir and 392.2182 for ISTD, respectively. The total chromatographic run time was 3.5 min and the assay exhibited a linear dynamic range of 0.039 -10 ng/ml in dog plasma. The developed method was successfully employed to support the bioavailability / pharmacokinetic study of valganciclovir formulations in dogs....
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