Frequency: Quarterly E- ISSN: 0976-7584 P- ISSN: 2229-4147 IBI Factor: 4, H-Index: 1, RI Factor 2.24, Global Impact Factor 0.76 (2015) Abstracted/ Indexed in: CNKI Scholar (China National Knowledge Infrastructure), CAS database (a division of the American Chemical Society), Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index
Quarterly published in print and online "Inventi Impact: NDDS" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under novel drug delivery systems. It welcomes articles pertaining to nano drug delivery systems; gastroretensive system, colonic drug delivery, bioadhesive and mucoadhesive systems; nasopulmonary drug delivery; ocular delivery; transdermal delivery, implants and inserts; protein and peptide delivery; manufacturing, quality control and regulatory aspects of NDDS, etc.
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that\ncan be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to\nutilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties.\nAs such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated\nin 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional\nmonolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns.\nThe possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen,\nwas also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve\ncustomised drug release patterns, whereby one drug was released immediately from a Kollicoat\nInstant Release matrix, whilst the effect of the second drug was sustained over an extended time\nspan using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate\nsmall and intricate formulations containing multiple active pharmaceutical ingredients with distinct\nrelease properties....
Background: Resveratrol effects on the prevention and treatment of colon\ncancer have been well documented recently, but low solubility, rapid\nabsorption and metabolism of resveratrol limit its beneficial effects on colon\ncancer. Designing a formulation that enhances the solubility of resveratrol,\nprotects resveratrol from oxidation and isomerization, and delivers it to the\ncolon is a priority of food and drug industry. In this study, resveratrolpolyethylene\nglycol (PEG)-loaded pectin-chitosan polyelectrolyte complex\nwas designed as a colon targeted delivery system.\nMethods: The effects of adding PEG, ultra-sonication time, pH, and pectin to\nchitosan ratio were investigated on particle size, polydispersity index (PDI),\nzeta potential by particle size analyzer, and scanning electron microscopy\n(SEM). Encapsulation efficiency (EE), release of resveratrol in simulated\ngastrointestinal fluid, and different pHs were analyzed via High Performance\nLiquid Chromatography (HPLC). Antioxidant activity was measured by (2, 2-\ndiphenyl-1-picryl-hydrazyl-hydrate) DPPH free-radical method.\nResults: Results showed that colloidal stable micro-particles (725 �± 20 nm)\nwith PDI < 0.3 and zeta potential +27 �± 2 mV was formed in the ratio of 5:1\nof pectin to chitosan w/v % after a 10-min sonication. Encapsulation\nefficiency was 81 �± 7 %. The reduction of antioxidant activity of resveratrol\nloaded micro-particles after one month was less than 13%. Micro-particles\nreleased about 33% of resveratrol in the simulated gastric and intestinal fluids.\nConclusion: Two-thirds of the loaded resveratrol in Pectin-Chitosan complex\nreached colon. The developed system had enough specification for enriching\nfruit based drinks due to remarkable colloidal stability in the pH range of 3.5\nto 4.5....
Aqua Gel is a network of polymer chains that are water-insoluble, sometimes found as a colloidal gel in which water is the dispersion medium and also sometime they are in the form of cross linked polymer networks that absorb substantial amounts of aqueous solutions. Aqua Gels have been introduced suitable as novel materials for a variety of applications such as biomedical engineering, sanitary products, agriculture, bioseparation, enhanced oil recovery, etc. They have been successfully used as superabsorbent materials and in drug delivery, cell encapsulation and tissue repair due to their high water content and consequent biocompatibility. The rate and degree of Aqua Gel swelling are the most important parameters which control the release patterns of solvents and drugs from these polymeric networks. PH sensitive and temperature sensitive Aqua Gels can be used for site specific controlled drug delivery. Aqua Gels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems. The aim of this article is to present a concise review on the applications of Aqua Gels in the pharmaceutical field, Aqua Gel properties, and method of preparation of Aqua Gel, advantages and disadvantages of Aqua Gel....
Mild acid response nanocarriers have been intensively attracted interest in the field of drug delivery on the account of the responsive\nproperty to abnormal physiological environment as well as the original property to normal physiological environment. However,\nthe drug delivery system lacks capacity of precise localization to abnormal tissue or targeted cells. Therefore, a magnetic and pHsensitive\ncomposite nanoparticle was designed and prepared by double water-in-oil-in-water (W/O/W) emulsion using acetylated\nÃ?²-cyclodextrin (Ac-Ã?²-CD) as a dominant material to realize the pH response and Fe3O4 as a component to realize magnetic\nresponse. The surface chemical characteristic was characterized by Fourier-transformed infrared spectroscopy (FTIR) using pure\nAc-Ã?²-CD nanoparticle as a control and exhibits the typical chemical characteristic of Ac-Ã?²-CD. Furthermore, the structural\ninformation was tracked by X-ray diffraction (XRD) and thermogravimetric analysis (TG). It was found that composite\nnanoparticle possessed structural characteristic of both Ac-Ã?²-CD and Fe3O4. Composite nanoparticle exhibited sphere and\ntwo-phase morphology with the diameter of about 200ââ?¬â??250nm depending on their detection method and zeta potential of âË?â??12\nto âË?â??14 mV. More importantly, irreversible pH response property and reversible magnetic responsive properties either in\nneutral environment or in mild acid environment for the composite nanoparticle were confirmed in the research. Finally, drug\nloading and release behavior were investigated through preliminary in vitro evaluation....
Hydrogels are among the most common materials used in drug delivery, as polymeric\nmicelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this\npaper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with\nthe specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination\ntherapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking\nof a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically\ndegraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles\nwere physicochemically characterized and subjected to UV irradiation to form what we called the\nâ??nanogridsâ?. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and\nbeclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug\nwas specifically assessed to verify that it can spread along the hydrophilic portions and, therefore,\neffectively released. These systems can open new pharmaceutical applications for known hydrogels\nor micelle systems, considering that in literature only few examples are present....
In this study efforts were made to design matrix tablet containing superporous hydrogel particles (SPHPs) for sustained delivery of Ranitidine hydrochloride. The SPHPs were prepared from superporous hydrogel of poly(AM-co-AA). The characterization studies for SPH were performed by measurement of apparent density, porosity, swelling studies, and scanning electron microscopy (SEM) studies. SEM images clearly indicated the formation of interconnected pores, and capillary channels. The SPHPs were found to be low dense, highly porous and highly swellable. The prepared tablet floated and delivered the Ranitidine hydrochloride for about 12 hour. To ascertain the kinetics of drug release, the dissolution profiles were fitted to mathematical models that include zero-order, first-order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas, Weibull, and Hopfenberg. The in vitro drug release from proposed system was best explained by the Hopfenberg model indicating that the release of drug from tablets displayed heterogeneous erosion. It is concluded that the proposed gastroretentive drug-delivery system based on SPHPs is promising for stomach specific delivery of Ranitidine hydrochloride....
Cancer remains a major threat to human health worldwide. Cytotoxicity has imposed\nrestrictions on the conventional cytotoxic drug-based chemotherapy. The rapidly-developing\nnanomedicine has shown great promise in revolutionizing chemotherapy with improved efficiency\nand reduced toxicity. Gd@C82(OH)22, a novel endohedral metallofullerenol, was first reported by\nour research group to suppress tumor growth and metastasis efficiently without obvious toxicity.\nGd@C82(OH)22 imprisons tumors by facilitating the formation of surrounding fibrous layers which is\ndifferent from chemotherapeutics that poison tumor cells. In this review, the authors first reported\nthe antineoplastic activity of metallofullerenol Gd@C82(OH)22 followed by further discussions\non its new anti-cancer molecular mechanism-tumor encaging. On this basis, the unparalleled\nadvantages of nanomedicine in the future drug design are discussed. The unique interaction modes\nof Gd@C82(OH)22 with specific targeted biomolecules may shed light on a new avenue for drug\ndesign. Depending on the surface characteristics of target biomolecules, nanomedicine, just like a\ntransformable and dynamic key, can self-assemble into suitable shapes to match several locks for the\nthermodynamic stability, suggesting the target-tailoring ability of nanomedicine....
Ongoing aortic wall degeneration and subsequent aneurysm exclusion failure are major\nconcerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would be a drug\ntherapy that targets the aortic wall and inhibits wall degeneration. Here, we described a novel drug\ndelivery system, which allowed repetitively charging a graft with therapeutic drugs and releasing\nthem to the aortic wall in vivo. The system was composed of a targeted graft, which was labeled with\na small target molecule, and the target-recognizing nanocarrier, which contained suitable drugs. We\ndeveloped the targeted graft by decorating a biotinylated polyester graft with neutravidin. We created\nthe target-recognizing nanocarrier by conjugating drug-containing liposomes with biotinylated\nbio-nanocapsules. We successfully demonstrated that the target-recognizing nanocarriers could bind\nto the targeted graft, both in vitro and in blood vessels of live mice. Moreover, the drug released\nfrom our drug delivery system reduced the expression of matrix metalloproteinase-9 in mouse aortas.\nThus, this hybrid system represents a first step toward an adjuvant therapy that might improve the\nlong-term outcome of endovascular aneurysm repair....
The vesicular approach of drug delivery is mainly comprised of the colloidal particles formed as a concentric bio molecular layer that are capable of encapsulating drugs inside themselves. They are usually employed to deliver the associated drug through the q, into the deeper tissues and systemic circulation. These carriers are composed of the lipids similar to the lipids present in the stratum corneum. These Structures consist of either a stack of multi-bilayer or a large number of single lipid bilayer, in the form of closed vesicles. These vesicles are utilized as a useful model representing the biological membranes and act as a well-situated medium intended for the delivery of a variety of agents. Ethosomes are the advanced approach to vesicular delivery comprised of hydroalcoholic phospholipid in which the concentration of ethanol is relatively in the range of 20-50%. The synergistic effect of comparatively high concentration of ethanol in Ethosomes has been the main reason intended for their superior skin permeability by simultaneously getting squeezed and causing the disruption on lipid bilayers present in the stratum corneum. Various drugs when associated with an ethosomes appear to have much more efficient delivery systems than classic vesicular approaches. For example, Bacitracin, a polypeptide antibiotic, was delivered from ethosomes to a depth of 200 �µm in a human cadaver skin, whereas its delivery of classic liposomes was negligible. Study with an ethosomal erythromycin demonstrated an improved antibacterial action, flux of Trihexyl phenidyl Hydrochloride an anti-Parkinsonian agent was substantially higher than that from conventional liposomes. Similar results have been reported for Propranolol Hydrochloride and Sodium Diclofenac. Ethosomal formulations of testosterone have been compared with marketed transdermal patches, shows significantly higher AUC and Cmax values....
Nano size drug particles refers to the particle size from 1-1000nm are emerging as an excellent vehicles for the delivery of the many poorly water soluble drug compound. Because of their versatile nature and unique advantages like large surface area,increased saturation solubility and ability to be incorporated in various range of dosage form like parenteral, peroral, ocular and pulmonary routes have made them very enticing for the formulation scientists around the world. A pharmaceutical nanosuspension contains colloid particles dispersed in an suitable vehicle mostly aqueous without any matrix material , stabilized by surfactants or polymers mainly by media milling and High pressure homogenization or combination of both. This review describes the definition, basic characteristics, advantages, methods of preparation, characterization, name of patented technology and its current market formulation....
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