Inventi Impact - NDDS
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: NDDS’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under novel drug delivery systems. It welcomes articles pertaining to nano drug delivery systems; gastroretensive system, colonic drug delivery, bioadhesive and mucoadhesive systems; nasopulmonary drug delivery; ocular delivery; transdermal delivery, implants and inserts; protein and peptide delivery; manufacturing, quality control and regulatory aspects of NDDS, etc.
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DEVELOPMENT AND EVALUATION OF THIOCOLCHICOSIDE LOADED MICROSPHERES
Thiocolchicoside is a semi synthetic drug derived from colchicoside used as a muscle relaxant as well as an anti-inflammatory agent. It has high aqueous solubility and low bioavailability. Hence, the aim of this study was to prolong the release of thiocolchicoside by developing polymeric microspheres. Microspheres were produced by ionotropic gelation technique to prolong the release of thiocolchic...
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FORMULATION AND EVALUATION OF SERTACONAZOLE NITRATE MICROSPONGE GEL
In the present study, controlled release sertaconazole nitrate (SZN) microsponge gel for topical delivery was formulated and evaluated. Microsponges were prepared successfully using six different proportions of ethyl cellulose as a polymer, using PVA as surfactant by the quasi-emulsion solvent diffusion method. The influence of the drug to polymer ratio, surfactant concentration, inner phase volum...
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EXPLORING THE STATE-OF-ART OF NANOSUSPENSIONS: THEORETICAL ASPECTS, FORMULATION AND CHARACTERIZATION
Nanosuspensions have emerged as a promising strategy for the efficient delivery of drugs because of their versatile features and unique advantages. Nanosuspensions are colloidal dispersions and biphasic system consisting of drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1 μm in size. Reduction of drug particles to nanometer range lead...
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CYCLODEXTRIN BASED METAXALONE NANOCRYSTALS: ROLE IN SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT
The present work employed preparation of metaxalone nanocrystals (MNC) by emulsion solvent diffusion method using β-cyclodextrin (CD) as stabilizer. Nanocrystals were characterized for morphology by scanning electron microscopy, crystallinity by powder x-ray diffraction and particle size by zeta sizer. Solubility study of metaxalone (MTX) and MNC was performed in distilled water, 7.4 phosphate ...
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DESIGN, DEVELOPMENT AND EVALUATION OF ORLISTAT LIPOSOMAL DRUG DELIVERY SYSTEMS
In this study, orlistat liposomes were developed and characterized for the physical as well as chemical parameters by ethanol injection method. Formula optimization studies were utilized to investigate the impact of different molar ratios of orlistat drug, soya phosphatidylcholine and cholesterol on physical appearance, pH, density, % drug entrapment efficiency, particle size, polydispersity index...
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DESIGN AND CHARACTERIZATION OF ACYCLOVIR NANOCRYSTALS FOR ENHANCEMENT OF SOLUBILITY AND BIOAVAILABILITY
The objective of this research work was to enhance solubility and dissolution profile of acyclovir. Nanocrystals were prepared by an anti-solvent precipitation process supplemented by sonication using different stabilizers. The formed nanocrystals were of 376-1085 nm in size. Formulations NC7 and NC8 showed marked improvement in dissolution compared to pure drug, thus greater bioavailability. Thes...
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