Inventi Impact - NDDS
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: NDDS’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under novel drug delivery systems. It welcomes articles pertaining to nano drug delivery systems; gastroretensive system, colonic drug delivery, bioadhesive and mucoadhesive systems; nasopulmonary drug delivery; ocular delivery; transdermal delivery, implants and inserts; protein and peptide delivery; manufacturing, quality control and regulatory aspects of NDDS, etc.
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FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF FELODIPINE LOADED ETHOSOMES
The purpose of this work was to develop felodipine-loaded ethosomes to advance its therapeutic efficacy through transdermal delivery. Ethosomes (ES) were fabricated via a 31.21 mixed full factorial design, the factors considered were; phospholipid amount (200 mg and 300 mg), Felodipine amount (10 mg and 20 mg) and ethanol percentage (10% and 15 % v/v). All ethosomes were formulated with thin-film ...
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FORMULATION AND CHARACTERIZATION OF SUSTAINED RELEASE MULTIPARTICULATE GASTRORETENTIVE DOSAGE FORM OF BACLOFEN
The objective of the study was to formulate and evaluate once daily, multiparticulate gastroretentive dosage form of baclofen for achieving sustained drug release, reducing side effects and frequency of administration leading to improved patient compliance. Gastroretention was achieved by designing multilayered effervescent pellets using extrusion spheronization technique. The pellet core containe...
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DEVELOPMENT AND EVALUATION OF THIOCOLCHICOSIDE LOADED MICROSPHERES
Thiocolchicoside is a semi synthetic drug derived from colchicoside used as a muscle relaxant as well as an anti-inflammatory agent. It has high aqueous solubility and low bioavailability. Hence, the aim of this study was to prolong the release of thiocolchicoside by developing polymeric microspheres. Microspheres were produced by ionotropic gelation technique to prolong the release of thiocolchic...
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FORMULATION AND EVALUATION OF SERTACONAZOLE NITRATE MICROSPONGE GEL
In the present study, controlled release sertaconazole nitrate (SZN) microsponge gel for topical delivery was formulated and evaluated. Microsponges were prepared successfully using six different proportions of ethyl cellulose as a polymer, using PVA as surfactant by the quasi-emulsion solvent diffusion method. The influence of the drug to polymer ratio, surfactant concentration, inner phase volum...
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EXPLORING THE STATE-OF-ART OF NANOSUSPENSIONS: THEORETICAL ASPECTS, FORMULATION AND CHARACTERIZATION
Nanosuspensions have emerged as a promising strategy for the efficient delivery of drugs because of their versatile features and unique advantages. Nanosuspensions are colloidal dispersions and biphasic system consisting of drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1 μm in size. Reduction of drug particles to nanometer range lead...
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CYCLODEXTRIN BASED METAXALONE NANOCRYSTALS: ROLE IN SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT
The present work employed preparation of metaxalone nanocrystals (MNC) by emulsion solvent diffusion method using β-cyclodextrin (CD) as stabilizer. Nanocrystals were characterized for morphology by scanning electron microscopy, crystallinity by powder x-ray diffraction and particle size by zeta sizer. Solubility study of metaxalone (MTX) and MNC was performed in distilled water, 7.4 phosphate ...
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