Frequency: Quarterly E- ISSN: Awaited P- ISSN: Awaited Abstracted/ Indexed in: Ulrichâ??s International Periodical Directory, Google Scholar, SCIRUS, getCITED
Quarterly published in print and online â??Inventi Rapid/Impact: Cardiology & Haematology (Formerly Inventi Rapid/Impact: Blood)â?? publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal welcomes papers in all the areas of hematology including basic laboratory, translational, and clinical investigations in hematology. The focus areas are disorders of leukocytes, both benign and malignant, erythrocytes, platelets, hemostatic mechanisms, vascular biology, immunology, and hematologic oncology.
Blood pressure is one important risk factor for stroke prognosis. Therefore, continuous monitoring of blood pressure is crucial\nfor preventing and predicting stroke. However, current blood pressure devices are mainly air-cuff based, which only can provide\nmeasurements intermittently. This study proposed a newblood pressure estimation method based on the pulse transit time to realize\ncontinuous monitoring.Theproposedmethod integrated a linear model with a compensation algorithm. A calibration method was\nfurther developed to guarantee that the model was personalized for individuals. Variation and variability of pulse transit time were\nintroduced to construct the compensation algorithm in the model. The proposed method was validated by the data collected from\n30 healthy subjects, aged from 23 to 25 years old. By comparing the estimated value to the measurement from an oscillometry,\nthe result showed that the mean error of the estimated blood pressure was ?0.2 �± 2.4mmHg and 0.5 �± 3.9mmHg for systolic\nand diastolic blood pressure, respectively. In addition, the estimation performance of the proposed model is better than the linear\nmodel, especially for the diastolic blood pressure. The results indicate that the proposed method has promising potential to realize\ncontinuous blood pressure measurement....
Background: Congenital thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman Syndrome\nis a rare inherited deficiency of ADAMTS13. Unlike the more common acquired TTP which is characterized by an\nacquired inhibitor of ADAMTS13, patients with congenital TTP have an absolute deficiency of ADAMTS13 without\nan inhibitor. Congenital TTP generally presents in infancy with repeat episodes of acute hemolysis and evidence of\nmicroangiopathy, these episodes are usually triggered by illness or physiological stress. Congenital TTP can be effectively\ntreated with plasma infusion either during acute episodes or on a prophylactic schedule to prevent episodes.\nCase presentation: We present a case of a 25 year old Caucasian woman with no know family history of hematological\ndisorders with congenital TTP. She presented with episodes of hemolysis since infancy, but without clear evidence\nof microangiopathy until the age of 25. At presentation to our center the patient was documented to have\nthrombocytopenia, elevated creatinine, and schistocytes. She was initially treated with plasma infusion at a rate of\n60 ml/hr continuously for a 24 hr period with resolution of her thrombocytopenia and hemolysis. At the time of\nwriting this article she is maintained on a prophylactic schedule of biweekly plasma infusions at 10 mg/kg and is\nmaintaining a normal platelet count with no evidence of hemolysis.\nConclusion: Congenital TTP is a rare condition, and the above case is atypical as the patient did not present with\nclear evidence of microangiopathy until adulthood. Although this a rare condition it is important for physicians to\nbe aware of as it, especially the possibility of atypical presentations, as the condition is potentially fatal and\neffective treatment exists....
Hemophagocytic lymphohistiocytosis (HLH), which was first described in\n1939 by paediatricians Scott and Robb-Smith, is a life-threatening disease.\nHLH is characterized as cytokine release syndrome which is caused by excessive\nbut non-malignant activation of macrophages and/or histiocytes in bone\nmarrow and other reticuloendothelial systems. EBV-HLH is the most common\ntype of infection-associated HLH, has a high mortality rate without\nprompt and effective treatment. A previous study showed that the one-year\nmortality rate of EBV-HLH patients is 75%. Here we report a case of\nEBV-associated hemophagocytic syndrome in adult, and the lessons from the\ntreatment process. Through this case, we think that for EBV-related HLH,\nEBV-DNA should also be monitored in addition to hemophagocytosis-\nrelated indicators during treatment. In addition, DEP regimen may not be\nsuitable for patients who have received at least partial response, because impaired\nimmunological functioning may lead to EBV and hemophagocytic\nre-activity....
Background: Large thrombus burdens in ectatic coronary arteries that remain after aspiration thrombectomy can\nnegatively impact outcomes following percutaneous coronary interventions in patients with acute myocardial\ninfarction.\nCase presentation: A 53-year-old man presented with ST-segment elevation myocardial infarction (STEMI).\nCoronary angiography revealed an ectatic right coronary artery (RCA) that was completely occluded in the mid\nportion by a large amount of thrombus. Catheter-directed intracoronary thrombolysis with alteplase led to recovery\nof coronary blood flow, which multiple attempts of aspiration thrombectomy had failed to achieve. Coronary\nangiography 9 days later showed good blood flow and insignificant stenosis remaining in the RCA; this had\ncompletely resolved in 6 months� follow-up coronary angiography.\nConclusion: Catheter-directed intracoronary thrombolysis can be performed effectively and safely when repeat\naspiration thrombectomy fails to produce satisfactory coronary reperfusion in STEMI patients with large thrombus\nburdens in ectatic coronary arteries....
Background. Volume of red cells in capillary blood varies from that of venous blood.The magnitude of this variation as well as its\r\nimpact on the diagnosis of anaemia in pregnancy needs to be studied. This study demonstrates the disparity between capillary and\r\nvenous PCV in pregnancy. Objectives. To determine whether capillary blood PCV (cPCV) differed fromvenous blood PCV (vPCV)\r\nof normal pregnant women in Enugu, Nigeria, and its effect on diagnosis and prevalence of anaemia. Methods. PCVwas estimated\r\nusing pairs of venous and capillary blood samples from 200 consecutive pregnant women at the Antenatal Clinic of University\r\nof Nigeria Teaching Hospital, Enugu, Nigeria. Results. Participantsââ?¬â?¢ cPCV (median = 34.0%, IQR = 31.0ââ?¬â??35.8) was significantly\r\nlower than their vPCV (median = 34.0%, IQR = 32.0ââ?¬â??37.0) (?? = -6.85, ?? < 0.001). However, womenââ?¬â?¢s cPCV had strong positive\r\ncorrelation with their vPCV (?? = 0.883, ?? < 0.001). The prevalence of anaemia among participants using capillary and venous\r\nblood was 33.5% (67/200) and 28.0% (56/200), respectively (O.R = 1.3 (CI 95%: 0.85, 1.98), ?? = 0.233). Conclusions. Capillary\r\nblood PCV was lower than vPCV among pregnant women in Enugu, Nigeria. Nevertheless, the prevalence of anaemia derived\r\nfrom cPCV did not differ significantly from that of vPCV....
Background\nThe Electronic Medical Record (EMR) is a potential source for high throughput phenotyping to conduct genome-wide association studies (GWAS), including those of medically relevant quantitative traits. We describe use of the Mayo Clinic EMR to conduct a GWAS of red blood cell (RBC) traits in a cohort of patients with peripheral arterial disease (PAD) and controls without PAD.\n\nMethodology and Principal Findings\nResults for hemoglobin level, hematocrit, RBC count, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were extracted from the EMR from January 1994 to September 2009. Out of 35,159 RBC trait values in 3,411 patients, we excluded 12,864 values in 1,165 patients that had been measured during hospitalization or in the setting of hematological disease, malignancy, or use of drugs that affect RBC traits, leaving a final genotyped sample of 3,012, 80% of whom had =2 measurements. The median of each RBC trait was used in the genetic analyses, which were conducted using an additive model that adjusted for age, sex, and PAD status. We identified four genomic loci that were associated (P<5Ã?â??10-8) with one or more of the RBC traits (HBLS1/MYB on 6q23.3, TMPRSS6 on 22q12.3, HFE on 6p22.1, and SLC17A1 on 6p22.2). Three of these loci (HBLS1/MYB, TMPRSS6, and HFE) had been identified in recent GWAS and the allele frequencies, effect sizes, and the directions of effects of the replicated SNPs were similar to the prior studies....
Background: Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening complication of pregnancy.\nThere is limited data regarding the predictors of persistent left ventricular (LV) systolic dysfunction. Recently, monocyteto-\nhigh density lipoprotein (HDL) cholesterol ratio (MHR) has emerged as a novel indicator of inflammation and\noxidative stress. We aimed to assess the predictive value of MHR on LV recovery in patients with PPCM.\nMethods: A total of 64 patients with PPCM who admitted to our tertiary reference hospital between 2009 and 2017\nwere retrospectively analyzed in this study. Demographic and clinical data, laboratory parameters and echocardiographic\nfindings were recorded. The duration of follow-up was at least 12months after diagnosis for all participants. Recovery of\nLV systolic function was defined as the presence of LV ejection fraction (LV EF) > 45%. Univariate analysis was used to\ndetermine the significant predictors of persistent LV systolic dysfunction (non-recovery). A receiver operating characteristic\n(ROC) curve was used to establish the cut-off values for predictors..........................
Background: Isolation of bone marrow cells, including hematopoietic stem cells, is a commonly used technique in\nboth the research and clinical settings. A quantitative and qualitative assessment of cell populations isolated from\nmouse and human bone marrow was undertaken with a focus on the distribution of hematopoietic cells between\nthe central bone marrow (cBM) and endosteal bone marrow (eBM).\nMethods: Two approaches to cBM isolation from the hind legs were compared using the C57BL/6J and BALB/cJ\nstrains of laboratory mice. The content of hematopoietic stem cells in eBM was compared to cBM from mice and\nhuman fetal bone marrow using flow cytometry. Enzymatic digestion was used to isolate eBM and its effects on\nantigen expression was evaluated using flow cytometry. Humanized immunodeficient mice were used to evaluate\nthe engraftment of human precursors in the cBM and eBM and the effects of in vivo maturation on the fetal stem\ncell phenotype were determined.\nResults: The two methods of mouse cBM isolation yielded similar numbers of cells from the femur, but the faster\nsingle-cut method recovered more cells from the tibia. Isolation of eBM increased the yield of mouse and human\nstem cells. Enzymatic digestion used to isolate eBM did, however, have a detrimental effect on detecting the\nexpression of the human HSC-antigens CD4, CD90 and CD93, whereas CD34, CD38, CD133 and HLA-DR\nwere unaffected. Human fetal HSCs were capable of engrafting the eBM of immunodeficient mice and their\npattern of CD13, CD33 and HLA-DR expression partially changed to an adult pattern of expression about\n1 year after transplantation.\nConclusions: A simple, rapid and efficient method for the isolation of cBM from the femora and tibiae of\nmice is detailed. Harvest of tibial cBM yielded about half as many cells as from the femora, representing\n6.4 % and 13 %, respectively, of the total cBM of a mouse based on our analysis and a review of the\nliterature. HSC populations were enriched within the eBM and the yield of HSCs from the mouse and\nhuman long bones was increased notably by harvest of eBM....
Ebsteinââ?¬â?¢s anomaly is a rare congenital heart disease that presents with apical displacement of the septal and posterior leaflets of the\ntricuspid valve. It has a wide spectrum of clinical presentations and has been shown to manifest itself any time from birth to\nadulthood. Our patient is a 43-year-old male with a history of intravenous heroin abuse who presented to the emergency department\nwith worsening shortness of breath and lower extremity edema. He denied any prior cardiac history. A transthoracic echo showed\nnormal left ventricular function, but a large 2.2 Ã?â?? 2.1 cm echodensity on the septal leaflet of the tricuspid valve consistent with\nvegetation with severe tricuspid regurgitation and probable leaflet perforation. It also demonstrated severe right heart enlargement\nwith atrialization of the right ventricle and apical displacement of the tricuspid valve consistent with Ebsteinââ?¬â?¢s anomaly. This is a rare\ncase of an adult who presented with asymptomatic Ebsteinââ?¬â?¢s anomaly. There have been few reports of tricuspid valve endocarditis\nwith Ebsteinââ?¬â?¢s anomaly in the literature. To our knowledge, this represents the fifth reported case of a new diagnosis of Ebsteinââ?¬â?¢s\nanomaly in the setting of endocarditis and the second case of Ebsteinââ?¬â?¢s anomaly and endocarditis in an intravenous drug abuser....
Objectives.The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis.\nSpecific blood groups may be more common in patients with endometriosis. Study Design. We designed a cross-sectional study\nof 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven\nendometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and\nRhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. We observed a\nhigher proportion of Rh-negativewomen in the study group, as compared to healthy controls.Multivariate analysis showed that Rhnegative\nwomen are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20ââ?¬â??2.90). There was no significant difference\nin ABO group distribution between patients and controls. There was no difference when taking into account either the clinical\nforms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages. Conclusion. Rh-negative\nwomen are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also\nharbor endometriosis susceptibility genes....
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