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Inventi Impact - Pulmonology
(Formerly Inventi Rapid/Impact: Lungs)

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    Journal Scope:

    Quarterly published in print and online ‘Inventi Rapid/Impact: Pulmonology (Formerly Inventi Rapid/Impact: Lungs)’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal welcomes papers in all the areas of the respiratory system. The focus areas are asthma, COPD, cystic fibrosis, infectious lung diseases, pulmonary circulation, respiratory immunology, sleep-related respiratory problems, lung cancer, lung transplantation, tuberculosis and pulmonary hypertension.

  • TOBACCO AND ITS EFFECTS
    Ayub Basha Shaik, Swaroopa Sandhya, Saran Kumar Sakey, Rupa Ragahvi Yantapalli, Jyothi Jupalli, Yerraguntla Hrushi Kesava Reddy, Banothu Mohan, Reddenna Languluri, Sree Naga Valli, Dinesh R    Download Full Text

    Tobacco use is the leading cause of preventable illness and death. Tobacco is the risk factor for 6 out of 8 leading causes of death in the world. It has been estimated that there are 1.1 billion smokers worldwide and 182 million (16.6%) of them live in India. It has been predicted by the world health organization (WHO) that more than 500 million people alive today will be killed by tobacco by ...

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  • PHENOTYPING COMMUNITY-ACQUIRED PNEUMONIA ACCORDING TO THE PRESENCE OF ACUTE RESPIRATORY FAILURE AND SEVERE SEPSIS
    Stefano Aliberti, Anna Maria Brambilla, James D Chalmers, Catia Cilloniz, Julio Ramirez, Angelo Bignamini,Elena Prina, Eva Polverino, Paolo Tarsia, Alberto Pesci, Antoni Torres, Francesco Blasi, Roberto Cosentini    Download Full Text

    Background: Acute respiratory failure (ARF) and severe sepsis (SS) are possible complications in patients with community-acquired pneumonia (CAP). The aim of the study was to evaluate prevalence, characteristics, risk factors and impact on mortality of hospitalized patients with CAP according to the presence of ARF and SS on admission. Methods: This was a multicenter, observational, prospective st...

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  • THE VITAMIN E ISOFORMS ?-TOCOPHEROL AND ?-TOCOPHEROL HAVE OPPOSITE ASSOCIATIONS WITH SPIROMETRIC PARAMETERS: THE CARDIA STUDY
    Michelle E Marchese, Rajesh Kumar, Laura A Colangelo, Pedro C Avila, David R Jacobs Jr, Myron Gross, Akshay Sood, Kiang Liu, Joan M Cook-Mills    Download Full Text

    Background: Clinical studies of the associations of vitamin E with lung function have reported conflicting results. However, these reports primarily examine the a-tocopherol isoform of vitamin E and have not included the isoform ?-tocopherol which we recently demonstrated in vitro opposes the function of a-tocopherol. We previously demonstrated, in vitro and in animal studies, that the vitamin ...

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  • HEPARIN BINDING VEGF ISOFORMS ATTENUATE HYPEROXIC EMBRYONIC LUNG GROWTH RETARDATION VIA A FLK1-NEUROPILIN-1-PKC DEPENDENT PATHWAY
    Americo E Esquibies, Anil Karihaloo, Susan E Quaggin, Alia Bazzy-Asaad, Lloyd G Cantley    Download Full Text

    Background: Previous work in our laboratory demonstrated that hyperoxia suppressed the expression of vascular endothelial growth factor (VEGF) by the embryonic lung, leading to increased epithelial cell apoptosis and failure of explant airway growth and branching that was rescued by the addition of Vegf165. The aims of this study were to determine protective pathways by which VEGF isoforms attenua...

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  • JNK SUPPRESSES PULMONARY FIBROBLAST ELASTOGENESIS DURING ALVEOLAR DEVELOPMENT
    Sheng Liu, Harikrishnan Parameswaran, Sarah M Young, Brian M Varisco    Download Full Text

    Background: The formation of discrete elastin bands at the tips of secondary alveolar septa is important for normal alveolar development, but the mechanisms regulating the lung elastogenic program are incompletely understood. JNK suppress elastin synthesis in the aorta and is important in a host of developmental processes. We sought to determine whether JNK suppresses pulmonary fibroblast elastoge...

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  • REGENERATIVE DEFECT IN VASTUS LATERALIS MUSCLE OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Marie-Eve Theriault, Marie-Eve Pare, Bruno B Lemire, Francois Maltais, Richard Debigare    Download Full Text

    Background: Impaired skeletal muscle regeneration could contribute to the progression of muscle atrophy in patients with chronic obstructive pulmonary disease (COPD). Methods: Satellite cells and myogenesis-related proteins were compared between healthy subjects and patients with COPD, with or without muscle atrophy. Satellite cells were isolated and cultured to assess their proliferative and diff...

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