Inventi Impact - Pharm Analysis & Quality Assurance
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharm Analysis & Quality Assurance’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutical analysis and quality assurance. It welcomes articles pertaining to qualitative and quantitative analysis of drugs, excipients, and impurities etc. to meet the regulatory requirements; analysis of modern and traditional medicines; quality control methods for biological drugs; quantitative and qualitative analysis in the drug screening processes; tracer analysis in molecular pharmacology; clinical and biological analysis, etc.
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NEW LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION OF LEDIPASVIR AND RELATED IMPURITY BY RP-HPLC IN BULK AND PHARMACEUTICAL DOSAGE FORMS
The present work aims at development and validation of reverse phase liquid chromatographic method for determination of ledipasvir and related impurity in bulk and pharmaceutical dosage form. The chromatographic separation was achieved with Zorbax eclipse XDB C18 column (250 mm x 4.6 mm, 5 micro) using buffer (0.03 M potassium dihydrogen phosphate in 1000 ml water) and acetonitrile (40:60). The fl...
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PHARMACOLOGICAL EVALUATION OF BETA SECRETASE INHIBITORS
Alzheimer’s disease (AD) progresses due to beta amyloid aggregation and decreased acetylcholine level. Amyloid-Beta peptide (ABeta) formed by the continuous proteolytic processing of Beta-amyloid precursor protein (Beta APP) by Beta-secretase (BACE1) and Gamma-secretase (BACE2), plays a vital role in the pathogenesis of alzheimer’s disease (AD). Evaluated dipeptides and octapeptides exhibit in...
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ESTIMATION OF ARTICAINE HCL AND EPINEPHRINE BY VOLTAMMETRY USING NANOMODIFIED ZIRCONIUM ELECTRODE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Uncomplicated, accurate and short analysis time analysis was elaborated for quantification of Articaine HCl (ART HCl) and Epinephrine (EPI). The electrochemical behavior of both articaine and epinephrine was carried out by applying differential pulse voltammetry (DPV) using Pencil graphite (PGE), carbon paste (CPE) and Nanomodified zirconium (ZRE) electrodes. The effect of experimental parameters ...
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DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR ESTIMATION OF DARIFENACIN HYDROBROMIDE IN LIPOSOMES
A simple and sensitive liquid chromatographic method was developed for the estimation of darifenacin hydrobromide in liposomes. Analysis was carried out on Enable 18H C18 column using a mobile phase consisting of phosphate buffer pH 3 and acetonitrile (60:40 %v/v). The mobile phase was pumped at a flow rate of 1 ml/min and UV-detection was carried out at 284 nm. Linearity was observed over concent...
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ANALYTICAL METHOD DEVELOPMENT AND INVESTIGATION OF CAFFEINE CONTENT FROM COFFEA ARABICA AND ANTI-OBESITY FORMULATION AS PER ICH Q2 (R1) PROTOCOL OF VALIDATION
Precise and sophisticated HPTLC and HPLC methods were developed for determination of caffeine from coffee bean extract. HPTLC analysis was performed on silica gel 60 F254 plate using ethyl acetate: methanol: water in the proportion of 10: 1.4: 1 (v/v/v) as mobile phase. A clear band of caffeine was observed at Rf value 0.55 (+0.1). Caffeine shows linearity within the concentration range of 200-600...
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SIMULTANEOUS ESTIMATION OF RIBOCICLIB AND PALBOCICLIB IN BULK SAMPLES BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
This work concerns with the development and validation of a simple, specific and cost effective RP-HPLC method for simultaneous estimation of ribociclib and palbociclib in bulk samples. Chromatography was carried on Kromasil C18 column with mobile phase comprising of 20 mM phosphate buffer (pH-5): methanol: acetonitrile (40:30:30, v/v/v). The flow rate was adjusted to 1 ml/min with PDA detection a...
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