Inventi Impact - Pharm Analysis & Quality Assurance
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharm Analysis & Quality Assurance’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutical analysis and quality assurance. It welcomes articles pertaining to qualitative and quantitative analysis of drugs, excipients, and impurities etc. to meet the regulatory requirements; analysis of modern and traditional medicines; quality control methods for biological drugs; quantitative and qualitative analysis in the drug screening processes; tracer analysis in molecular pharmacology; clinical and biological analysis, etc.
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RP-HPLC METHOD DEVELOPMENT FOR THE DETERMINATION OF RIZATRIPTAN BENZOATE IN BULK DRUG AND TABLET DOSAGE FORM
A simple, rapid, accurate, precise and reproducible RP-HPLC method for the estimation of rizatriptan benzoate in bulk and tablet dosage form was developed and validated as per ICH guidelines. The separation was done using Enable C18 G 150 x 4.6 mm, 5μ column. The mobile phase (water and methanol; 80:20% v/v) was pumped at 1.0 ml/min and effluent was detected at 225 nm using a PDA detector. The re...
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DEGRADATION KINETIC STUDY OF DIFLUPREDNATE BY USING VALIDATED STABILITY-INDICATING LIQUID CHROMATOGRAPHIC METHOD
The objective of this investigation was to study the degradation behavior and kinetics of the difluprednate from ophthalmic emulsion under different ICH recommended stress condition by validated stability indicating LC method for quantification of potential known and unknown degradation product. Chromatographic separation was achieved on the C-18 stationary phase with a gradient elution using a mo...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST AND RUPATADINE IN PHARMACEUTICAL DOSAGE FORM
The aim of the present study was the development and validation of a simple, precise and specific RP-HPLC method for assay of montelukast (MNT) and rupatadine (RPT) in tablet dosage forms. The separation was achieved on Grace C-18 Column (4.6 × 250 mm, 5 μm) using acetonitrile and 0.05% OPA (60:40, v/v) as mobile phase for assay, flow rate 1 ml/ min and detection was carried out in U.V detector ...
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SIMULTANEOUS ESTIMATION OF BACOSIDE A3, PIPERINE AND CROCIN IN POLYHERBAL FORMULATION BY CHEMOMETRIC ASSISTED RP-HPLC METHOD
A simple RP-HPLC method was developed and chemometric designs were applied for the simultaneous estimation of bacoside A3 (BA3), piperine (PPN) and crocin (CON) in polyherbal formulation brahmi vati. The separation was carried out by using phenomenex C18 column (15 cm • 4.6 mm id, 5 μm particle size). For the optimization the ranges of independent variables used were MeCN: 33–38%, buffer conc...
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STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF GATIFLOXACIN AND DEXAMETHASONE SODIUM PHOSPHATE IN OPHTHALMIC FORMULATION
A simple, accurate and precise stability indicating RP-HPLC method was developed for the simultaneous estimation of dexamethasone sodium phosphate (DSP) and gatifloxacin (GA) in ophthalmic formulation. Method was achieved in various degradation conditions like acidic, basic, oxidative, thermal and photolytic. Maximum degradation was found in acidic condition for DSP 29% and for GA in thermal condi...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF HYDROCHLOROTHIAZIDE AND SPIRANOLACTONE IN ITS COMBINED DOSAGE FORM
A new simple, sensitive and reproducible RP-HPLC method for the simultaneous estimation of hydrochlorothiazide and spiranolactone in pharmaceutical formulations was developed and validated. The separation was carried out on Phenomenex kinetex C18, 5 μm (250×4.6 mm) column with acetonitrile: sodium dihydrogen and disodium hydrogen orthophasphate pH 6.4, 50:50% v/v as the mobile phase at the flow ...
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