Inventi Impact - Med Chem
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Med Chem’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under medicinal and pharmaceutical chemistry. It welcomes articles pertaining to design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or ligands employed as pharmaceutical tools; molecular modifications of reported series leading to improved understanding of SAR; structural biological studies of relevant ligands and targets; computational chemistry methods; effect of molecular structure on biopharmaceutics, etc.
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DESIGN, MWI SYNTHESIS OF 1,4 DISUBSTITUTED AZETIDINONES AND THEIR PRELIMINARY ANTIPROLIFERATIVE EVALUATION ON VIGNA RADIATA
The class of tubuline inhibitors is still not very well understood. This category shows potential in several classes of drugs. We have exploited the nucleus for potential tubuline inhibitors. Chemical compounds that target microtubules and inhibit the normal function of the mitotic spindle, have proven to be one of the best classes of cancer chemotherapeutic drugs available to date. Recently, comb...
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ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF PHENYL AND ORTHO- HYDROXY PHENYL LINKED IMIDAZOLYL TRIAZOLO HYDROXAMIC ACID DERIVATIVES
Synthesized molecules (FP1-FP12) were evaluated against five fungal species as Candida albicans, Candida glabrata, Candida paropsialis, Candida tropicalis SSKM, Aspergillus niger using fluconazole as standard. Synthesized molecules (FP1-FP12) were evaluated against five Gram +ve and five Gram -ve bacetria such as Bacillus cereus (+ve), Staphaylococcus saprophyticus (+ve), Streptococcus gordoni (+v...
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FACILE SYNTHESIS, CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF NEWER OXADIAZOLE DERIVATIVES
Synthesis of 1, 3, 4-oxadiazole derivatives have attracted considerable attention in view of therapeutic applications. In the present research work, a series of 6-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-3aryl/heteryl[1,2,4]triazolo[3,4- b][1,3,4]oxadiazole compounds was synthesized by treating 1-[5-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazol-2- yl] hydrazine with the corresponding ...
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SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SCHIFF BASES DERIVED FROM PYRROLE-2-CARBOXALDEHYDE
In this work, we have synthesized thirteen (SB1-SB13) Schiff bases derived from condensation reaction of pyrrole-2- carboxaldehyde with different aniline derivatives. The structures of the synthesized products were confirmed by physicochemical and spectral (IR and 1H NMR) means. These compounds were screened for their antimicrobial activity against five bacterial and two fungal strains and their a...
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SYNTHESIS AND STUDY OF BIOLOGICAL ACTIVITIES OF NOVEL ANALOGUES OF TETRALINS
Podophyllotoxin belongs to the cyclolignan family of natural products. It exhibits cathartic, cytotoxic, antimitotic, anticancer and other biological activities. The new podophyllotoxin analogues were synthesized in very good yields by heating 3, 4, 5-trimethoxybenzaldehyde, succinic anhydride and amine derivatives in ethanol at 60°C. All the products were characterized by spectral and elemental ...
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SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF SOME NEW N-((3-(4- CHLOROPHENYL)-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOL-1-YL)METHYL)- SUBSTITUTED AMINE DERIVATIVES
The present study refers to the synthesis of new antidepressant candidates using the pyrazoline scaffold. In an attempt to identify potential lead antidepressant agents, a number of N-((3-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol- 1-yl)methyl)-substituted amine (mannich base) were synthesized by microwave assisted synthesis. The antidepressant activity of the synthesized compounds (3a–3h)...
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