Inventi Impact - Med Chem
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Med Chem’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under medicinal and pharmaceutical chemistry. It welcomes articles pertaining to design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or ligands employed as pharmaceutical tools; molecular modifications of reported series leading to improved understanding of SAR; structural biological studies of relevant ligands and targets; computational chemistry methods; effect of molecular structure on biopharmaceutics, etc.
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PHARMACOLOGICAL EVALUATION OF SYNTHESIZED NOVEL FLAVANONE INCORPORATED SEMICARBAZIDES DERIVATIVES AGAINST PTZ INDUCED CONVULSION AND TAIL IMMERSION INDUCED ANALGESIA IN RATS
Some novel flavanones incorporated semicarbazide derivatives (Y2e–Y2j) were synthesized. The derivatives were characterized by physico-chemical (TLC and melting point) and spectral analysis (I.R., N.M.R and mass spectroscopy) and finally the biological activities were performed by using different animal models like pentylenetetrazole-induced convulsions in rats for anti-convulsant activity and t...
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DESIGN, SYNTHESIS OF 1-[2-(FURAN-2-YL)-2,3-DIHYDROCHROMEN-4- YLIDENE]-4-PHENYLSEMI-CARBAZONE AGAINST PTZ INDUCED CONVULSION, TAIL IMMERSION INDUCED ANALGESIA, PAW EDEMA INDUCED INFLAMMATION IN RATS AND ANTIMICROBIAL SCREENING
Flavanones are polyphenols found in citrus fruits (lemons, grapefruits and oranges). They are so bioavailable that they can appear in blood plasma as soon as 20 minutes after ingestion, though their concentrations aren’t maximized until after about four hours. This makes flavanones a significant contributor to the antioxidant pool that circulates in your blood. However, since these flavanones ar...
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SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF SOME NOVEL SUBSTITUTED 1, 3, 4-OXADIAZOLE AND PYRAZOLE DERIVATIVES
A series of 1,3,4-oxadiazole and pyrazole derivatives have been synthesized and evaluated for anti-inflammatory activity. The structures of synthesized compounds were confirmed by IR, 1H NMR, Mass and CHN analysis. These compounds have shown promising anti-inflammatory activity when compared with the standard drug indomethacin....
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DESIGN, MWI SYNTHESIS OF 1,4 DISUBSTITUTED AZETIDINONES AND THEIR PRELIMINARY ANTIPROLIFERATIVE EVALUATION ON VIGNA RADIATA
The class of tubuline inhibitors is still not very well understood. This category shows potential in several classes of drugs. We have exploited the nucleus for potential tubuline inhibitors. Chemical compounds that target microtubules and inhibit the normal function of the mitotic spindle, have proven to be one of the best classes of cancer chemotherapeutic drugs available to date. Recently, comb...
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ANTIFUNGAL AND ANTIBACTERIAL ACTIVITIES OF PHENYL AND ORTHO- HYDROXY PHENYL LINKED IMIDAZOLYL TRIAZOLO HYDROXAMIC ACID DERIVATIVES
Synthesized molecules (FP1-FP12) were evaluated against five fungal species as Candida albicans, Candida glabrata, Candida paropsialis, Candida tropicalis SSKM, Aspergillus niger using fluconazole as standard. Synthesized molecules (FP1-FP12) were evaluated against five Gram +ve and five Gram -ve bacetria such as Bacillus cereus (+ve), Staphaylococcus saprophyticus (+ve), Streptococcus gordoni (+v...
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FACILE SYNTHESIS, CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF NEWER OXADIAZOLE DERIVATIVES
Synthesis of 1, 3, 4-oxadiazole derivatives have attracted considerable attention in view of therapeutic applications. In the present research work, a series of 6-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-3aryl/heteryl[1,2,4]triazolo[3,4- b][1,3,4]oxadiazole compounds was synthesized by treating 1-[5-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazol-2- yl] hydrazine with the corresponding ...
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