Inventi Impact - Med Chem
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Med Chem’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under medicinal and pharmaceutical chemistry. It welcomes articles pertaining to design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or ligands employed as pharmaceutical tools; molecular modifications of reported series leading to improved understanding of SAR; structural biological studies of relevant ligands and targets; computational chemistry methods; effect of molecular structure on biopharmaceutics, etc.
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SYNTHESIS AND CHARACTERIZATION OF SOME COUMARIN SCHIFF BASES AS POSSIBLE ANTITUBERCULAR AND ANTIBACTERIAL AGENTS
A series of coumarin Schiff bases, (E)-N’arylidine-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-acetohydrazides (IVa-m) were synthesized by the reaction of intermediate, acetohydrazide of coumarin(III) with different aryl/hetero aromatic aldehydes in chloroform:methanol (1:1) mixture, in presence of glacial acetic acid and characterized by IR, NMR and Mass spectral data. The title compounds were evalu...
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SYNTHESIS, INVESTIGATION OF ANTICANCER AND ANTIMICROBIAL ACTIVITY OF CERTAIN VANILLIN DERIVED 3,5-DISUBSTITUTED-1-SUBSTITUTED/UNSUBSTITUTED 2-PYRAZOLINES
Identifying a pressing need for the development of more effective and selective chemotherapeutic agents, compounds belonging to different panel of 2-pyrazolines derived from vanillin were synthesized from the corresponding chalcone intermediates in formic acid, acetic acid and alcohol leading to 5-(3-methoxy-4-hydroxyphenyl)-3-(substituted phenyl)-1-formyl-4,5-dihydro-1H-pyrazoles 2a-i, 5-(3-metho...
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SYNTHESIS, IN-SILICO CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF NOVEL OFLOXACIN DERIVATIVES
Synthesis and evaluation of ofloxacin derivatives were carried out and evaluated for their anthelmintic activity. Synthesized ofloxacin derivatives (Compounds 1-6) were purified by using of ethanol by recrystallization procedure and characterized the molecules by analytical methods (TLC), Spectroscopic methods (FT-IR, Mass and NMR). In-silico methods were adopted for synthetic derivatives by Molin...
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2D-QSAR STUDY ON SOME NOVEL 6-ACETYL-3-[3-CHLORO-2-(SUBSTITUTED)-4-OXOAZETIDIN-1-YL]-2, 5-DIPHENYL-2, 3-DIHYDROPYRIDINE-4-CARBONITRILE ANALOGUES AS ANTIMICROBIAL AGENT
A series of 6-Acetyl-3-[3-Chloro-2-(Substituted)-4-Oxoazetidin-1-yl]-2, 5-Diphenyl-2, 3-Dihydropyridine-4-Carbonitrile were screened for their antifungal activity against fungi Candida albicans. These compounds have showed moderate and very good antifungal activity. The Quantitative Structure Activity-Relationships (QSAR) study on the pyridine series was made using lipophilic, electronic and steri...
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SYNTHESIS AND EVALUATION OF NOVEL 1-SUBSTITUTED 7-AZAISATIN DERIVATIVES AS ANTI MICROBIAL AGENTS
A series of novel 1-substituted 7-azaisatin derivatives synthesized from 7-azaindole by oxidation with N bromosuccinamide further involves incorporation of isonicotino-hydrazide with 7-aza isatin then treated with various alkyl halides to give titled compounds and screened for antimicrobial activity. In view of the antimicrobial property of this pharmacophore it was visualized that its combined ef...
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SYNTHESIS AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF BENZAL AND ITS DERIVATIVES
Benzal derivatives were synthesized by crossed aldol. Benzalacetone synthesis was done by crossed aldol condensation between benzaldehyde and acetone with 1:1 mol ratio, while dibenzalacetone in 2:1 mol ratio. Benzalacetone derivatives were synthesized by replacing benzaldehyde with its derivatives, i.e. anisaldehyde, salicylacetone, cinnamaldehyde and p-hydroxyl benzalacetone. The mono derivative...
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