Inventi Impact - Med Chem
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Med Chem’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under medicinal and pharmaceutical chemistry. It welcomes articles pertaining to design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or ligands employed as pharmaceutical tools; molecular modifications of reported series leading to improved understanding of SAR; structural biological studies of relevant ligands and targets; computational chemistry methods; effect of molecular structure on biopharmaceutics, etc.
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2D-QSAR STUDY ON SOME NOVEL 6-ACETYL-3-[3-CHLORO-2-(SUBSTITUTED)-4-OXOAZETIDIN-1-YL]-2, 5-DIPHENYL-2, 3-DIHYDROPYRIDINE-4-CARBONITRILE ANALOGUES AS ANTIMICROBIAL AGENT
A series of 6-Acetyl-3-[3-Chloro-2-(Substituted)-4-Oxoazetidin-1-yl]-2, 5-Diphenyl-2, 3-Dihydropyridine-4-Carbonitrile were screened for their antifungal activity against fungi Candida albicans. These compounds have showed moderate and very good antifungal activity. The Quantitative Structure Activity-Relationships (QSAR) study on the pyridine series was made using lipophilic, electronic and steri...
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SYNTHESIS AND EVALUATION OF NOVEL 1-SUBSTITUTED 7-AZAISATIN DERIVATIVES AS ANTI MICROBIAL AGENTS
A series of novel 1-substituted 7-azaisatin derivatives synthesized from 7-azaindole by oxidation with N bromosuccinamide further involves incorporation of isonicotino-hydrazide with 7-aza isatin then treated with various alkyl halides to give titled compounds and screened for antimicrobial activity. In view of the antimicrobial property of this pharmacophore it was visualized that its combined ef...
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SYNTHESIS AND EVALUATION OF ANTIBACTERIAL ACTIVITY OF BENZAL AND ITS DERIVATIVES
Benzal derivatives were synthesized by crossed aldol. Benzalacetone synthesis was done by crossed aldol condensation between benzaldehyde and acetone with 1:1 mol ratio, while dibenzalacetone in 2:1 mol ratio. Benzalacetone derivatives were synthesized by replacing benzaldehyde with its derivatives, i.e. anisaldehyde, salicylacetone, cinnamaldehyde and p-hydroxyl benzalacetone. The mono derivative...
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KINETICS STUDY ON OXIDATION OF BENZALDEHYDE BY ISOQUINOLINIUM BROMOCHROMATE IN AQUEOUS ACETIC ACID MEDIUM
Chemical kinetics is a branch of chemistry concerned with the velocity of chemical reaction and the mechanism by which chemical occur. It deals with the rates of chemical reactions and how rates depend on factors such as concentration and temperatures. The kinetic study of benzaldehydes has been studied in binary solvent mixtures of water and chromic acid with isoquinolinium bromochromate in the p...
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SYNTHESIS OF SOME NOVEL COUMARINS COUPLED WITH 1,2,3-TRIAZOLES AS POTENT ANTIMICROBIAL AGENTS
Herein, we report the synthesis of some novel coumarins coupled with 1,2,3-triazoles. The structure of newly synthesized compounds was confirmed by 1HNMR, 13CNMR, mass spectroscopic and CHN analysis. The synthesized compounds were screened for their antimicrobial potency. Some of the compounds exhibited profound antibacterial activity as compared with the respective standard, ciprofloxacin. The an...
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DOCKING, SYNTHESIS, ADME PREDICTION AND β-LACTAMASE INHIBITORY ACTIVITY OF SOME 2-(5-H/ CHLORO-((PIPERAZIN-1-YLMETHYL)- 2-OXOINDOLIN-3-YLIDENE)-N-SUBSTITUTED HYDRAZINECARBOTHIOAMIDES
Various 2-(5-H/chloro-((piperazin-1-yl-methyl)-2-oxoindolin-3-ylidene)-N-substittuted hydrazine carbothioamides 4a–j were synthesized. The compounds were screened and evaluated for their β-Lactamase inhibitory activity with potassium clavulanate as a standard, amongst screened and evaluated chemical compounds. The compound 4e shown highest β-Lactamase inhibitory activity which was equ...
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