Inventi Impact - Genetics
(Formerly Inventi Rapid/Impact: Stem Cell)
-
Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Genetics (Formerly Inventi Rapid/Impact: Stem Cell)’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal focuses on all aspects of stem and progenitor cell biology. It invites articles related to stem cells, embryonic stem cells, induced pluripotent stem cells, tissue-specific stem cells, stem cell technology, epigenetics, genomics, proteomics, and metabonomics. Articles from cancer stem cells, translational and clinical research and regenerative medicine are also welcome.
-
HUMAN ADIPOSE-DERIVED STEM CELL TRANSPLANTATION AS A POTENTIAL THERAPY FOR COLLAGEN VI-RELATED CONGENITAL MUSCULAR DYSTROPHY
Introduction: Congenital muscular dystrophies (CMD) are a clinically and genetically heterogeneous group of neuromuscular disorders characterized by muscle weakness within the first two years of life. Collagen VI-related muscle disorders have recently emerged as one of the most common types of CMD. COL6 CMD is caused by deficiency and/or dysfunction of extracellular matrix (ECM) protein collage...
Read More -
MESENCHYMAL STEM CELLS INDUCE ENDOTHELIAL CELL QUIESCENCE AND PROMOTE CAPILLARY FORMATION
Introduction: Rapid establishment of functional blood vessels is a prerequisite for successful tissue engineering. During vascular development, endothelial cells (ECs) and perivascular cells assemble into a complex regulating proliferation of ECs, vessel diameter and production of extracellular matrix proteins. The aim of this study was to evaluate the ability of mesenchymal stem cells (MSCs) t...
Read More -
SOLUBLE FACTORS SECRETED BY DIFFERENTIATING EMBRYONIC STEM CELLS STIMULATE EXOGENOUS CELL PROLIFERATION AND MIGRATION
Introduction: Stem cells are being investigated as catalysts of tissue regeneration to either directly replace or promote cellularity lost as a result of traumatic injury or degenerative disease. In many reports, despite low numbers of stably integrated cells, the transient presence of cells delivered or recruited to sites of tissue remodeling globally benefits functional recovery. Such finding...
Read More -
HUMAN WHARTON’S JELLY MESENCHYMAL STEM CELLS PROMOTE SKIN WOUND HEALING THROUGH PARACRINE SIGNALING
Introduction: The prevalence of nonhealing wounds is predicted to increase due to the growing aging population. Despite the use of novel skin substitutes and wound dressings, poorly vascularized wound niches impair wound repair. Mesenchymal stem cells (MSCs) have been reported to provide paracrine signals to promote wound healing, but the effect of human Wharton’s jelly-derived MSCs (WJ-MSCs)...
Read More -
FUNCTIONAL DIFFERENTIATION OF MIDBRAIN NEURONS FROM HUMAN CORD BLOOD-DERIVED INDUCED PLURIPOTENT STEM CELLS
Introduction: Human induced pluripotent stem cells (hiPSCs) offer great promise for regenerative therapies or in vitro modelling of neurodegenerative disorders like Parkinson’s disease. Currently, widely used cell sources for the generation of hiPSCs are somatic cells obtained from aged individuals. However, a critical issue concerning the potential clinical use of these iPSCs is mutations th...
Read More -
EFFICIENT LARGE-SCALE GENERATION OF FUNCTIONAL HEPATOCYTES FROM MOUSE EMBRYONIC STEM CELLS GROWN IN A ROTATING BIOREACTOR WITH EXOGENOUS GROWTH FACTORS AND HORMONES
Introduction: Embryonic stem (ES) cells are considered a potentially advantageous source of hepatocytes for both transplantation and the development of bioartificial livers. However, the efficient large-scale generation of functional hepatocytes from ES cells remains a major challenge, especially for those methods compatible with clinical applications. Methods: In this study, we investigated w...
Read More