Inventi Impact - Pharmacokinetics & Pharmacodynamics
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharmacokinetics & Pharmacodynamics’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on all areas of pharmacokinetics and pharmacodynamics of drug substances and products including drug absorption, distribution, metabolism and excretion, and application of pharmacokinetics principles for effective management of drugs. Articles from the areas such as drug action, clinical pharmacokinetics, drug metabolites, dosage form evaluation in animals and humans, bioavailabilty studies, scaling from animals to humans, and in vitro and in vivo correlations are also welcome.
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EVALUATION OF THE PHARMACOKINETICS OF A SPARINGLY SOLUBLE MODEL DRUG FOLLOWING ORAL ADMINISTRATION OF A PROMISING CHRONOTHERAPEUTIC SYSTEM AND A REFERENCE PRODUCT IN HEALTHY VOLUNTEERS
The systems which combine the advantages of gastroretentive and pulsatile approaches are urgently needed to enhance drug absorption and allow its delivery at the time necessary to alleviate chronopathological complications. The current work aimed to explore the pharmacokinetics of theophylline anhydrous (THE) following oral administration of THE-loaded core-in-cup tablets and Quibron®-T tablets i...
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EFFECT OF QUETIAPINE ON PHARMACOKINETICS OF PIOGLITAZONE
The present study was performed to investigate the effect of quetiapine on the pharmacokinetics of pioglitazone. The blood samples were collected and analyzed for estimation of pioglitazone pharmacokinetics. The quetiapine alters the pharmacokinetics of pioglitazone. Quetiapine appears to produce pharmacokinetic interaction with pioglitazone. The increase in pioglitazone concentration might be due...
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THE EFFECT OF FOOD ON THE DRUG RELEASE AND FLOATING BEHAVIOR OF ACIDIC AND BASIC DRUGS
The purpose of this work was to study the effect of food on the drug release and floating behavior of gastro retentive dosage form. The objective was also to assess the role of biochemical property of drug in absorption. For this purpose ellagic acid was selected as acidic and monoammonium glycyrrhizin as basic drug. Floating tablet of both the drugs were prepared separately and evaluated for drug...
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EFFECT OF LOVASTATIN ON PHARMACOKINETICS OF PIOGLITAZONE
The effect of lovastatin on pharmacokinetics of pioglitazone has been carried out in albino rats. The rats were divided into 5 groups. Group 1: Normal control rats: Treated with vehicle (1% DMSO), Group 2: Diabetic control rats: Diabetes induction and no treatment, Group 3: Treatment Group: Diabetic rats treated with oral administration of pioglitazone (3 mg/kg), Group 4: Treatment Group: Diabetic...
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EFFECTS OF RHODODENDRON ARBOREUM EXTRACT ON PHARMACOKINETICS OF ISRADIPINE IN RATS
The present study was carried out to study the effects of Rhododendron arboreum extract on pharmacokinetic of isradipine in rats. Albino wistar rats (200-250 g) were used for pharmacokinetic study. Rats were divided into three groups. Group I were treated with only isradipine (1 mg/kg, p.o.). Group 2 and 3 were treated with Rhododendron arboreum extract (RAE) (100 and 200 mg/kg, p.o., respectively...
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CEREBRAL MICRODIALYSIS IN CLINICAL STUDIES OF DRUGS: PHARMACOKINETIC APPLICATIONS
The ability to deliver drug molecules effectively across the blood–brain barrier into the brain is important in the development of central nervous system (CNS) therapies. Cerebral microdialysis is the only existing technique for sampling molecules from the brain extracellular fluid (ECF; also termed interstitial fluid), the compartment to which the astrocytes and neurones are directly ex...
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