Inventi Impact - Gene Medicines
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Gene Medicines’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on the science of gene transfer and its applications in gene and cell therapy. The areas included are – vector design, delivery and targeting, gene expression and regulation, preclinical studies, developmental aspects and clinical trials.
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EXTRACELLULAR MATRIX MACROMOLECULES: POTENTIAL TOOLS AND TARGETS IN CANCER GENE THERAPY
Tumour cells create their own microenvironment where they closely interact with a variety of soluble and non-soluble molecules, different cells and numerous other components within the extracellular matrix (ECM). Interaction between tumour cells and the ECM is bidirectional leading to either progression or inhibition of tumourigenesis. Therefore, development of novel therapies targeted primarily t...
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GENE EXPRESSION PROFILING REVEALS ACTIVATION OF THE FA/BRCA PATHWAY IN ADVANCED SQUAMOUS CERVICAL CANCER WITH INTRINSIC RESISTANCE AND THERAPY FAILURE
Background: Advanced squamous cervical cancer, one of the most commonly diagnosed cancers in women, still remains a major problem in oncology due to treatment failure and distant metastasis. Antitumor therapy failure is due to both intrinsic and acquired resistance; intrinsic resistance is often decisive for treatment response. In this study, we investigated the specific pathways and molecules res...
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IMPROVEMENT OF SPINAL NON-VIRAL IL-10 GENE DELIVERY BY D-MANNOSE AS A TRANSGENE ADJUVANT TO CONTROL CHRONIC NEUROPATHIC PAIN
Background: Peri-spinal subarachnoid (intrathecal; i.t.) injection of non-viral naked plasmid DNA encoding the anti-inflammatory cytokine, IL-10 (pDNA-IL-10) suppresses chronic neuropathic pain in animal models. However, two sequential i.t. pDNA injections are required within a discrete 5 to 72-hour period for prolonged efficacy. Previous reports identified phagocytic immune cells present in the p...
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THE RELATIONSHIP BETWEEN THE ANTITUMOR EFFECT OF THE IL-12 GENE THERAPY AND THE EXPRESSION OF TH1 CYTOKINES IN AN HPV16-POSITIVE MURINE TUMOR MODEL
Objective. The goal of the present study was to investigate the effect of IL-12 expressed in plasmid on the Th1 cytokine profile in an experimental HPV16-positive murine tumor model and the association with the IL-12’s antitumor effect. Methods. Mice were injected with BMK-16/myc cells to establish HPV16-positive tumor and then pNGVL3-mIL-12 plasmid; pcDNA3 plasmid or PBS was injected direc...
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EXPERIMENTAL STUDY OF LOCAL INNER EAR GENE THERAPY FOR CONTROLLING AUTOIMMUNE SENSORINEURAL HEARING LOSS
This study aimed to investigate the efficacy of gene therapy for treating autoimmune sensorineural hearing loss (ASHL) via local administration of a recombinant adenovirus vector containing the Fas ligand or interleukin IL-10 gene. Guinea pigs were divided into four groups, with different microinjections in the scala tympani. Group A were injected with FasL-EGFP, B with IL-10-EGFP, C with EGFP, an...
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THE EXPANDING ROLE OF AEROSOLS IN SYSTEMIC DRUG DELIVERY, GENE THERAPY AND VACCINATION: AN UPDATE
Until the late 1990s, aerosol therapy consisted of beta2-adrenergic agonists, anti-cholinergics, steroidal and non-steroidal agents, mucolytics and antibiotics that were used to treat patients with asthma, COPD and cystic fibrosis. Since then, inhalation therapy has matured to include drugs that: (1) are designed to treat diseases outside the lung and whose target is the systemic circulation (s...
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