Inventi Impact - Biosimilars & Biopharmaceuticals
Formerly Inventi Rapid/Impact: Biosimilars
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Biosimilars & Biopharmaceuticals (Formerly Inventi Rapid/Impact: Biosimilars)’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on manufacture, development and usage of biopharmaceutical compounds considered similar to an innovator agent. The topics included are chemical composition and structure, quality and purity, patent issues, bioequivalence and interchangeability, clinical efficacy data, economic considerations etc.
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BIOSIMILARS OR BIOGENERICS: ITS PRESENT SCENARIO
Biosimilars are defined as the biotechnological products having patent expired and are found to possess almost similar properties as that of innovator products. In the next coming years there is great line up standing for patent expiry means there would be great blockbuster coming now. India is a hub of generic medicines means similar trend will be followed for the production of biosimilar product...
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COMPARATIVE EVALUATION OF LOCALLY PRODUCED AND IMPORTED INTERFERON BIOACTIVITY AND RELATED MX GENE EXPRESSION POTENTIALS IN DIFFERENT CELL LINES
The present work was aimed to study the biosimilarity of locally produced free IFN and innovated imported free one through evaluation of the antiviral activity of test interferons on different cell lines and related expression potentials of Mx protein producing gene. Evaluation of two alternative methods for evaluation the efficacy of antiviral interferon. Cytotoxicity of interferon was perform...
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COMPARATIVE EVALUATION OF RECOMBINANT PROTEIN PRODUCTION IN DIFFERENT BIOFACTORIES: THE GREEN PERSPECTIVE
In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity...
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RECOMBINANT HUMAN FOLLICLE-STIMULATING HORMONE (R-HFSH) PLUS RECOMBINANT LUTEINIZING HORMONE VERSUS R-HFSH ALONE FOR OVARIAN STIMULATION DURING ASSISTED REPRODUCTIVE TECHNOLOGY: SYSTEMATIC REVIEW AND META-ANALYSIS
Background: The potential benefit of adding recombinant human luteinizing hormone (r-hLH) to recombinant human follicle-stimulating hormone (r-hFSH) during ovarian stimulation is a subject of debate, although there is evidence that it may benefit certain subpopulations, e.g. poor responders. Methods: A systematic review and a meta-analysis were performed. Three databases (MEDLINE, Embase and CENTR...
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A SYNTHETIC BIOLOGY APPROACH TO SELF-REGULATORY RECOMBINANT PROTEIN PRODUCTION IN ESCHERICHIA COLI
Background: Recombinant protein production is a process of great industrial interest, with products that range from pharmaceuticals to biofuels. Since high level production of recombinant protein imposes significant stress in the host organism, several methods have been developed over the years to optimize protein production. So far, these trial-and-error techniques have proved laborious and sensi...
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PHARMACOKINETICS OF PEGYLATED RECOMBINANT HUMAN ERYTHROPOIETIN IN RATS
rHuEPO plays a central role as chemicals for the treatment of many diseases. Due to its short half-life, the main aim for this pharmacokinetic study is to investigate a newly developed PEG-rHuEPO with large molecular weight in SD rats. After a single intramuscular administration of different doses of 125I-PEG-rHuEPO, pharmacokinetic parameters, tissue distribution, and excretion were analyzed. In ...
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