Inventi Impact - Pharm Biotech & Microbio
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharm Biotech & Microbio’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on methods, applications and findings in pharmaceutical microbiology and biotechnology. Papers from all relevant areas such as antimicrobial studies, tissue culture technology, gene methods, enzyme technology, recombinant DNA technology, antibiotics screening and production are invited.
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IN-VITRO SCREENING OF WITHANIA SOMNIFERA LEAF AND ROOT EXTRACTS FOR ANTIFUNGAL ACTIVITIES USING NCCLS ASSAY
The aim of present research work was screening of leaves and root extracts of Withania somnifera plant to study its antifungal activity by NCCLS (National Chemical and Clinical Standard) assay against Candida albicans and Candida tropicalis using resazurin by microtiter plate assay. The leaves and root parts were extracted by soxhlet extraction using methanol and solvent ether. The Graph Pad Prism...
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PERSPECTIVES OF 2-(P-HYDROXYPHENYL)-4-(SUBSTITUTED-PHENYL)- 1H-1,5-BENZODIAZEPINES AS EMERGING CLASS OF ANTI-FUNGAL CANDIDATES
The present research involved screening of anti-fungal potentials of some 2-(p-hydroxyphenyl)-4–(substitutedphenyl)- 1H-1,5–benzodiazepine derivatives against Candida albicans (C. albicans, MTCC 227), Aspergillus niger (A. niger, MTCC 277) and Aspergillus flavus (A. flavus, MTCC 418). The compounds were previously reported by our group and the structures were established by sophisticated analy...
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STUDY ON THE CHANGING RESISTANCE PATTERN OF STAPHYLOCOCCUS AUREUS AND E. COLI TO AMOXYCILLIN-CLAVULANIC ACID COMBINATION
Antimicrobial resistance is a global concern as new mechanisms of resistance are emerging and spreading globally, threatening our ability to treat common infectious diseases, resulting in prolonged illness, disability and even death. The study was focused on comparing the effectiveness of amoxicillin alone and amoxicillin with clavulanate potassium in combination by checking the sensitivity/resist...
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CORRELATION BETWEEN RESISTANCE MARKERS AND ENTEROTOXINS HORIZONTAL TRANSFER IN STAPHYLOCOCCUS AUREUS ISOLATES
S. aureus represents a public health challenge worldwide on the basis of their resistance to antimicrobials as well as the production of certain virulence factors such as enterotoxins. Detection of enterotoxin production, plasmid profiles and antimicrobial susceptibility testing were carried out. Four out of 10 S. aureus isolates produced different types of enterotoxins. Plasmid profile revealed t...
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CORRELATION BETWEEN RESISTANCE MARKERS AND INVASION AS A VIRULENCE FACTOR OF SHIGELLA FLEXNERI ISOLATES
A total of 4 Shigella flexneri isolates showed positive sereny test indicating the capability of invasiveness. This was also confirmed by testing the adhesion and invasion to HeLa cells in-vitro. At the molecular level, inv gene was amplified and detected in the four test isolates at 320 bp. Susceptibility testing revealed multiple drug resistance in all of the isolates with two resistance pattern...
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SCREENING AND OPTIMIZATION OF CELLULASE ENZYME FROM THE LEAVES OF MANGROVE PLANT SPECIES RHIZOPHORA MUCRONATA
Cellulase can be derived from a variety of living organisms, ranging from micro-organisms to plants and humans. Microorganisms are the most important sources for the production of cellulase. In the present study the mangrove plant species Rhizophora mucronata were collected from Kurusadai Island, Mandapam, Rameswaram. In nutrient agar medium 18 × 102 CFU/g cells were isolated from the leaf sample...
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